Zobrazeno 1 - 10
of 11 135
pro vyhledávání: '"Granzyme"'
Publikováno v:
陆军军医大学学报, Vol 46, Iss 17, Pp 1959-1968 (2024)
Objective To investigate the feasibility of granzyme B (GB) promoter-controlled ferritin heavy chain (FTH1) reporter gene expression for monitoring the activation status of chimeric antigen receptor T cells (CAR-T) by magnetic resonance imaging (MRI)
Externí odkaz:
https://doaj.org/article/b92548c2f9ce47429828cc255be42a20
Publikováno v:
Journal of Inflammation Research, Vol Volume 17, Pp 4505-4523 (2024)
Xu Yang,1,* Jianwei Wu,1,* Longlong Fan,2 Binghua Chen,3 Shiqiang Zhang,4 Wenzhong Zheng1 1Department of Urology, Fujian Medical University Union Hospital, Fuzhou, People’s Republic of China; 2Department of Urology, The Eighth Affiliated Ho
Externí odkaz:
https://doaj.org/article/d5491e10b8d04b18b33f7c129c81be39
Autor:
Won-Dong Kim, Don D. Sin
Publikováno v:
COPD, Vol 21, Iss 1, Pp 1-11 (2024)
AbstractChronic obstructive pulmonary disease (COPD) is caused by smoking, but only a small proportion of smokers have disease severe enough to develop COPD. COPD is not always progressive. The question then arises as to what explains the different t
Externí odkaz:
https://doaj.org/article/a73fc2ca4d1947a69109af353104d22a
Autor:
Jiayi Yang, Xinyi Ding, Zhang Fang, Shaoxian Wu, Maoling Yuan, Rongzhang Chen, Qinlan Xu, Xinran Gao, Haoyu Wu, Lujun Chen, Xiao Zheng, Jingting Jiang
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract CD8+T cells secreting granzyme A (GZMA) can induce pyroptosis in tumor cells by effectively cleaving gasdermin B (GSDMB), which is stimulated by interferon-γ (IFN-γ). However, the interaction between GZMA-expressing CD8+T cells and GSDMB-e
Externí odkaz:
https://doaj.org/article/2a6a89298a6f4656ac5255126ad989d9
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Natural killer (NK) cells are closely associated with malignant tumor progression and metastasis. However, studies on their relevance in colorectal cancer (CRC) are limited. We aimed to comprehensively analyze the absolute counts, phenotypes
Externí odkaz:
https://doaj.org/article/6ecaab6f7e0d4ccd8aa28b0f6c0c178e
Publikováno v:
Case Reports in Dermatology, Vol 16, Iss 1, Pp 116-122 (2024)
Introduction: Anti-PD-1 immunotherapies enhance T-cell responses against tumor cells by blocking the interaction between PD-1 and its ligand, PD-L1. While these therapies offer significant benefits in treating various malignancies, they can also lead
Externí odkaz:
https://doaj.org/article/d9ddab1b96014fc38f4d71c9a40e216b
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background Antibody drug conjugates (ADCs) constitute a promising class of targeted anti-tumor therapeutics that harness the selectivity of monoclonal antibodies with the potency of cytotoxic drugs. ADC development is best suited to initiall
Externí odkaz:
https://doaj.org/article/8685e81748f54f4d91d70ca7f5c59c64
Autor:
Kazumi Okamura, Lifang Wang, Satoshi Nagayama, Makiko Yamashita, Tomohiro Tate, Saki Matsumoto, Manabu Takamatsu, Shigehisa Kitano, Kazuma Kiyotani, Yusuke Nakamura
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
TCRαβ+ CD4− CD8− double-negative T (DNT) cells are minor populations in peripheral blood, and their roles have mostly been discussed in inflammation and autoimmunity. However, the functions of DNT cells in tumor microenvironment remain to be el
Externí odkaz:
https://doaj.org/article/e90401bc94a44e26b863b56cc2c0e6fd
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