The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework

Autor: Anastasia Albert, Lars Ellgaard, Mads M. Foged, Terje Vasskog, Samuel D. Robinson, Cecilie L. Søltoft, Raymond S. Norton, Baldomero M. Olivera, Kaare Teilum, Andreas B. Bertelsen, Anthony W. Purcell, Lau Dalby Nielsen, Steen V. Petersen, Helena Safavi-Hemami

Publikováno v: Nielsen, L D, Foged, M M, Albert, A, Bertelsen, A B, Søltoft, C L, Robinson, S D, Petersen, S V, Purcell, A W, Olivera, B M, Norton, R S, Vasskog, T, Safavi-Hemami, H, Teilum, K & Ellgaard, L 2019, ' The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework ', The Journal of Biological Chemistry, vol. 294, no. 22, pp. 8745-8759 . https://doi.org/10.1074/jbc.RA119.007491
Nielsen, L D, Foged, M M, Albert, A, Bertelsen, A B, Søltoft, C L, Robinson, S D, Petersen, S V, Purcell, A W, Olivera, B M, Norton, R S, Vasskog, T, Safavi-Hemami, H, Teilum, K & Ellgaard, L 2019, ' The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework ', The Journal of biological chemistry . https://doi.org/10.1074/jbc.RA119.007491
J Biol Chem
Nielsen, L D, Foged, M M, Albert, A, Bertelsen, A B, Søltoft, C L, Robinson, S D, Petersen, S V, Purcell, A W, Olivera, B M, Norton, R S, Vasskog, T, Safavi-Hemami, H, Teilum, K & Ellgaard, L 2019, ' The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework ', Journal of Biological Chemistry, vol. 294, no. 22, pp. 8745-8759 . https://doi.org/10.1074/jbc.RA119.007491

Venomous marine cone snails produce peptide toxins (conotoxins) that bind ion channels and receptors with high specificity and therefore are important pharmacological tools. Conotoxins contain conserved cysteine residues that form disulfide bonds tha

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