Zobrazeno 1 - 10
of 1 045
pro vyhledávání: '"Granulin"'
Autor:
Wonjae Sung, Min-Young Noh, Minyeop Nahm, Yong Sung Kim, Chang-Seok Ki, Young-Eun Kim, Hee-Jin Kim, Seung Hyun Kim
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-20 (2024)
Abstract Background Progranulin (PGRN) haploinsufficiency due to progranulin gene (GRN) variants can cause frontotemporal dementia (FTD) with aberrant TAR DNA-binding protein 43 (TDP-43) accumulation. Despite microglial burden with TDP-43-related pat
Externí odkaz:
https://doaj.org/article/19fbfd4b830b44a1a55a436512698939
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 9, p 332 (2024)
Background: The polarization of macrophages plays a critical role in the immune response to infectious diseases, with M2 polarization shown to be particularly important in various pathological processes. However, the specific mechanisms of M2 macroph
Externí odkaz:
https://doaj.org/article/87df4fc35ad64c90b549ff3fe9adaf26
Publikováno v:
Parasites & Vectors, Vol 16, Iss 1, Pp 1-16 (2023)
Abstract Background Clonorchis sinensis granulin (CsGRN), a component of the excretory/secretory products of this species, is a multifunctional growth factor that can promote the metastasis of cholangiocarcinoma cells. However, the effect of CsGRN on
Externí odkaz:
https://doaj.org/article/8bf2576fa3ae494d85a5f74c8ea8edf8
Akademický článek
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Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
αD-conotoxins are 11 kDa homodimers that potently inhibit nicotinic acetylcholine receptors (nAChRs) through a non-competitive (allosteric) mechanism. In this study, we describe the allosteric binding mode of the granulin-like C-terminal (CTD) of Vx
Externí odkaz:
https://doaj.org/article/1bbe3088b29c42e59b5e011995cb27b8
Autor:
Qiaofeng Qian, Fengjiao Hu, Wenjun Yu, Dewen Leng, Yang Li, Hongjie Shi, Dawei Deng, Kehan Ding, Chuan Liang, Jinping Liu
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 7 (2023)
Background Pathological cardiac hypertrophy is regarded as a critical precursor and independent risk factor of heart failure, and its inhibition prevents the progression of heart failure. Switch‐associated protein 70 (SWAP70) is confirmed important
Externí odkaz:
https://doaj.org/article/591285a6fd1f4cc4b43320c2c77f756f
Autor:
Tingting Zhang, Huan Du, Mariela Nunez Santos, Xiaochun Wu, Mitchell D. Pagan, Lianne Jillian Trigiani, Nozomi Nishimura, Thomas Reinheckel, Fenghua Hu
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-12 (2022)
Abstract Background Haploinsufficiency of progranulin (PGRN) is a leading cause of frontotemporal lobar degeneration (FTLD). PGRN is comprised of 7.5 granulin repeats and is processed into individual granulin peptides in the lysosome. However, very l
Externí odkaz:
https://doaj.org/article/63dfd99a4a9848ad96214c257ffd37aa
Akademický článek
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Autor:
Swetha Mohan, Paul J. Sampognaro, Andrea R. Argouarch, Jason C. Maynard, Mackenzie Welch, Anand Patwardhan, Emma C. Courtney, Jiasheng Zhang, Amanda Mason, Kathy H. Li, Eric J. Huang, William W. Seeley, Bruce L. Miller, Alma Burlingame, Mathew P. Jacobson, Aimee W. Kao
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-18 (2021)
Abstract Background Progranulin loss-of-function mutations are linked to frontotemporal lobar degeneration with TDP-43 positive inclusions (FTLD-TDP-Pgrn). Progranulin (PGRN) is an intracellular and secreted pro-protein that is proteolytically cleave
Externí odkaz:
https://doaj.org/article/2bcbf5d1642d41eea3c3e628a2a7b9be
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
The biological functions of growth factor, such as granulins, have been explored in parasites, and we elucidated that Clonorchis sinensis granulin (CsGRN) promoted the metastasis of hepatocellular carcinoma in our previous study. However, it is still
Externí odkaz:
https://doaj.org/article/782eb554ac32426b83386b955d631693