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Multicomponet Synthesis of Pyrrolo [3,4-a] Carbazole-1,3-Diones

Autor: Ana G. Neo, Jesús Díaz, Ana Bornadiego, Carlos F. Marcos

Publikováno v: The 23rd International Electronic Conference on Synthetic Organic Chemistry.

Pyrrolocarbazoles are important structural motives present in many natural products and pharmaceuticals. Particularly, pyrrolo [3,4-a] carbazole-1,3-diones have attracted much attention as analogues of bioactive compounds, such as anticancer agent gr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a2d687e668baaacade84fefc07e21a6
https://doi.org/10.3390/ecsoc-23-06525

Marine Pyrrolocarbazoles and Analogues: Synthesis and Kinase Inhibition

Autor: Evelyne Delfourne, Sébastien Deslandes, Stefan Chassaing

Publikováno v: Marine Drugs
Marine Drugs, Vol 7, Iss 4, Pp 754-786 (2009)

Granulatimide and isogranulatimide are alkaloids obtained from marine sources which have been shown to inhibit cell-cycle G2-checkpoint, targeting more particularly checkpoint 1 kinase (Chk1). At a structural level, they possess a characteristic pyrr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0754b56ec924845f22b11bf8ba1ceff3
https://doi.org/10.3390/md7040754

Expedited Synthesis of Substituted Dipyrrolo[3,4-a:3,4-c]carbazole-1,3,4,6-tetraones Structurally Related to Granulatimide

Autor: Bruno Pfeiffer, Armelle Loynel, Nathalie Kucharczyk, Hélène Henon, Fabrice Anizon, Patrick Casara, Michelle Prudhomme

Publikováno v: Synthesis. 2006:711-715

Dipyrrolo[3,4-a:3,4-c]carbazole-1,3,4,6-tetraones can be considered as granulatimide analogues. In view of structure-activity relationship studies in these series, a parallel liquid-phase microwave-assisted synthesis was developed to generate a small

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a3cac7a8f78fc289e826581625e72b4
https://doi.org/10.1055/s-2006-926308

Synthesis of granulatimide bis-imide analogues

Autor: Bruno Pfeiffer, Fabrice Anizon, Bernadette Hugon, Michelle Prudhomme, Samir Messaoudi, Hélène Henon

Publikováno v: Tetrahedron
Tetrahedron, Elsevier, 2005, 61, pp.5599-5614. ⟨10.1016/j.tet.2005.03.101⟩
Tetrahedron, 2005, 61, pp.5599-5614. ⟨10.1016/j.tet.2005.03.101⟩

The synthesis of dipyrrolo[3,4-a:3,4-c]carbazole-1,3,4,6-tetraones, structurally related to granulatimide is reported. These compounds can be considered as granulatimide analogues in which a maleimide heterocycle replaces the imidazole moiety. The sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53cc66174b141100216158790b088888
https://doi.org/10.1016/j.tet.2005.03.101