Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Grant Zurcher"'
Autor:
Elena Giudice, Tzu-Ting Huang, Jayakumar R. Nair, Grant Zurcher, Ann McCoy, Darryl Nousome, Marc R. Radke, Elizabeth M. Swisher, Stanley Lipkowitz, Kristen Ibanez, Duncan Donohue, Tyler Malys, Min-Jung Lee, Bernadette Redd, Elliot Levy, Shraddha Rastogi, Nahoko Sato, Jane B. Trepel, Jung-Min Lee
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The multi-cohort phase 2 trial NCT02203513 was designed to evaluate the clinical activity of the CHK1 inhibitor (CHK1i) prexasertib in patients with breast or ovarian cancer. Here we report the activity of CHK1i in platinum-resistant high-gr
Externí odkaz:
https://doaj.org/article/a32a2dc2018942d5a1dda8aa8f8851d8
Autor:
Nitasha Gupta, Tzu-Ting Huang, Jayakumar R. Nair, Daniel An, Grant Zurcher, Erika J. Lampert, Ann McCoy, Ashley Cimino-Mathews, Elizabeth M. Swisher, Marc R. Radke, Christina M Lockwood, Jonathan B. Reichel, Chih-Yuan Chiang, Kelli M. Wilson, Ken Chih-Chien Cheng, Darryl Nousome, Jung-Min Lee
PARP inhibitors (PARPis) have changed the treatment paradigm inBRCA-mutant high-grade serous ovarian carcinoma (HGSC). However, most patients eventually develop resistance to PARPis, highlighting an unmet need for novel therapeutic strategies. Using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f693361a258ac8c32a330772e35f83c0
https://doi.org/10.1101/2022.12.02.22283037
https://doi.org/10.1101/2022.12.02.22283037
Autor:
Elena Giudice, Grant Zurcher, Jayakumar Nair, Tzu-Ting Huang, Min-Jung Lee, Jane B. Trepel, Jung-Min Lee
Publikováno v:
Cancer Research. 83:1562-1562
Background: High unmet needs exist to develop novel therapeutics and identify biomarkers to predict response in PR-HGSOC. We previously reported clinical activity of CHK1 inhibitor (CHK1i), prexasertib (a.k.a.ACR-368) in heavily pretreated BRCAwt PR-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73463c3b1f83deb13e893a050c306e2e
https://doi.org/10.1158/1538-7445.am2023-1562
https://doi.org/10.1158/1538-7445.am2023-1562
Publikováno v:
Cancers. 14:1219
RecQ helicases are essential for DNA replication, recombination, DNA damage repair, and other nucleic acid metabolic pathways required for normal cell growth, survival, and genome stability. More recently, RecQ helicases have been shown to be importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e2499ecc7d4d8289d6f04e12a64b3ce
https://doi.org/10.3390/cancers14051219
https://doi.org/10.3390/cancers14051219
Autor:
Matthew R. Bell, Andres A. Caro, Shannon Ejiofor, Martin J. J. Ronis, Grant Zurcher, Dennis R. Petersen
Publikováno v:
Alcoholism, clinical and experimental research. 38(12)
Background Chronic ethanol (EtOH) administration to experimental animals induces hepatic oxidative stress and up-regulates mitochondrial biogenesis. The mechanisms by which chronic EtOH up-regulates mitochondrial biogenesis have not been fully explor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2908a0f69306f88fdeec5a53323a19b
https://pubmed.ncbi.nlm.nih.gov/25581647
https://pubmed.ncbi.nlm.nih.gov/25581647
Publikováno v:
Cancer Research. 72:5628-5628
Estrogen receptor (ERα) is the fundamental transcription factor in breast cancer progression and a majority of breast cancers start as ERα positive. Therapies targeting ERα are effective; however, many eventually develop resistance and recur as me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::358340ecb807fa227fd8a53d7d2f4096
https://doi.org/10.1158/1538-7445.am2012-5628
https://doi.org/10.1158/1538-7445.am2012-5628