Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Grant Wishart"'
Autor:
Grant Wishart, Guido Lanza
Publikováno v:
Genetic Engineering & Biotechnology News. 43:16-17, 19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fccf33fe4113588cc9886873e5540734
https://doi.org/10.1089/gen.43.04.06
https://doi.org/10.1089/gen.43.04.06
Autor:
David Harrison, Mark G. Bock, John R. Doedens, Christopher A. Gabel, M. Katharine Holloway, Arwel Lewis, Jane Scanlon, Andrew Sharpe, Iain D. Simpson, Pamela Smolak, Grant Wishart, Alan P. Watt
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1321-1328
The NLRP3 inflammasome is a multiprotein complex that facilitates activation and release of the proinflammatory cytokines interleukin-1β (IL-1β) and IL-18 in response to infection or endogenous stimuli. It can be inappropriately activated by a rang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67241e433174d9710ad5069778aac5f6
https://doi.org/10.1021/acsmedchemlett.2c00242
https://doi.org/10.1021/acsmedchemlett.2c00242
Autor:
Marieke Lamers, Grant Wishart, Karen Barnes, Graham D. Smith, Ivan Angulo-Herrera, Sarah L. Martin, Rebecca E. Jarvis, Wesley Blackaby, Philip Leonard, Ovadia Lazari, Leticia Toledo-Sherman, David F. Fischer, Maria Eznarriaga, Simon J. Dowler, George McAllister, Rhea van de Bospoort, Dawn Yates, Annelieke Strijbosch, Helen C. Cox, Jennifer R. Bate, Esmieu William R K, Amanda Van de Poël, Roger Cachope, Sung-Wook Jang, Perla Breccia, Celia Dominguez, Mark Rose, Kim L. Matthews, Huw D. Vater, Stephen D. Penrose, Ignacio Munoz-Sanjuan
Publikováno v:
Journal of medicinal chemistry. 62(6)
Genetic and pharmacological evidence indicates that the reduction of ataxia telangiectasia-mutated (ATM) kinase activity can ameliorate mutant huntingtin (mHTT) toxicity in cellular and animal models of Huntington's disease (HD), suggesting that sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a89407c2d2edecea9555cc23f334e43
https://pubmed.ncbi.nlm.nih.gov/30840447
https://pubmed.ncbi.nlm.nih.gov/30840447
Autor:
C. Rouse, Gary Clark, K.L. Hirst, H. Habashita, A.P. Owens, M. Higashino, S. Kawahadara, A. Imagawa, Arwel Lewis, Scott A. Maidment, A.M. Macleod, A. Rae, A. Beresford, Grant Wishart, M. Nakanishi, M.S. Chambers, T. Saito, D.C. Hartley
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127536
The identification and SAR development of a series of negative allosteric modulators of the GABAA α5 receptor is described. This novel series of compounds was optimised to provide analogues with high GABAA α5 binding affinity, high α5 negative all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed566b835b70b651030de2914241f079
https://doi.org/10.1016/j.bmcl.2020.127536
https://doi.org/10.1016/j.bmcl.2020.127536
Autor:
Christopher A. Luckhurst, Omar Aziz, Vahri Beaumont, Roland W. Bürli, Perla Breccia, Michel C. Maillard, Alan F. Haughan, Marieke Lamers, Phil Leonard, Kim L. Matthews, Gilles Raphy, Andrew J. Stott, Ignacio Munoz-Sanjuan, Beth Thomas, Michael Wall, Grant Wishart, Dawn Yates, Celia Dominguez
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(1)
We have identified a potent, cell permeable and CNS penetrant class IIa histone deacetylase (HDAC) inhibitor 22, with500-fold selectivity over class I HDACs (1,2,3) and ∼150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform. Dose escalati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc52289ed1bc17170b0a3a38854cb42
https://pubmed.ncbi.nlm.nih.gov/30463802
https://pubmed.ncbi.nlm.nih.gov/30463802
Autor:
Lindsay Gibson, David R. Barn, Mark Craighead, William Arbuckle, Rachel Milne, Hazel Sloan, Chris Claxton, Susan Elizabeth Napier, Matilda Bingham, Grant Wishart, Cliona P MacSweeney, Richard Goodwin, N.G. Irving, Zara Turnbull, Kirsteen Buchanan, Jeremy Presland, Angus R. Brown, Alan Byford, Chris Mort, Fiona Thomson, Susan Goutcher, James R. Baker, Lee Fielding, Trevor Young
The discovery of a novel series of 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamide antagonists of the vasopressin V(1A) receptor is disclosed. Compounds 47 and 48 were found to be high affinity, selective vasopressin V(1A) antagonists.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc0d41bbebfcb82e69bfeb8a58ca72c
https://doi.org/10.1016/j.bmcl.2011.02.096
https://doi.org/10.1016/j.bmcl.2011.02.096
Autor:
Miki Nakanishi, Kim Louise Hirst, Tetsuya Yasuhiro, Nobuto Nakanishi, Scott A. Maidment, Masato Higashino, Seishi Katsumata, Gary Clark, Mark Stuart Chambers, Soichi Kawaharada, Arwel Lewis, Keisuke Hazama, Grant Wishart
Publikováno v:
Alzheimer's & Dementia. 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c6cc119383854a3c9e2279c060539c8
https://doi.org/10.1016/j.jalz.2016.06.2096
https://doi.org/10.1016/j.jalz.2016.06.2096
Autor:
Celia Dominguez, Marieke Lamers, Samantha J. Hughes, Rebecca E. Jarvis, Grant Wishart, Helen L. Birch, Roland Bürli, Omar Aziz, Scott Pollack, Dawn Yates, Perla Breccia, Christopher A. Luckhurst, Philip Leonard, Andrew J. Stott, George McAllister, Kim L. Matthews, Elizabeth Anne Saville-Stones
Potent and selective class IIa HDAC tetrasubstituted cyclopropane hydroxamic acid inhibitors were identified with high oral bioavailability that exhibited good brain and muscle exposure. Compound 14 displayed suitable properties for assessment of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2917976f54e5700b574a852afba864e3
https://europepmc.org/articles/PMC4716601/
https://europepmc.org/articles/PMC4716601/
Autor:
Anna Marie Easson, Yasuko Kiyoi, Steven Laats, Keneth Davies, Mark Reid, Stuart Francis, Helen Feilden, Grant Wishart, Peter C. Ray, Takao Kiyoi, Duncan McArthur
Publikováno v:
Tetrahedron Letters. 52:3421-3425
Tetrahydro-2H-[2]benzopyrano[3,4-c]pyrrol-3-ones and the related 3a-methyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]isoindole analogues were synthesised by an intramolecular Diels–Alder reaction. The observed stereoselectivity was dependent upon the natu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e98dd78627adaeac91ba7e0416023ed
https://doi.org/10.1016/j.tetlet.2011.03.053
https://doi.org/10.1016/j.tetlet.2011.03.053
Publikováno v:
Tetrahedron Letters. 52:3417-3420
Hexahydro[2]benzopyrano[4,3- c ]pyridines were synthesized by an intramolecular hetero Diels–Alder reaction. The reaction was applicable to a range of substrates and the products could be easily converted into serotonin 5-HT 2C receptor agonists.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e948a43bfc083413870749aa08c164a
https://doi.org/10.1016/j.tetlet.2011.03.054
https://doi.org/10.1016/j.tetlet.2011.03.054