Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Grant W Booker"'
Autor:
Christine Böttcher, Eric G Dennis, Grant W Booker, Steven W Polyak, Paul K Boss, Christopher Davies
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37632 (2012)
An important process for the regulation of auxin levels in plants is the inactivation of indole-3-acetic acid (IAA) by conjugation to amino acids. The conjugation reaction is catalysed by IAA-amido synthetases belonging to the family of GH3 proteins.
Externí odkaz:
https://doaj.org/article/04ae804bec09483d99a3559e9980cc47
Autor:
Clair L Alvino, Shee Chee Ong, Kerrie A McNeil, Carlie Delaine, Grant W Booker, John C Wallace, Briony E Forbes
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27488 (2011)
BACKGROUND: Insulin-like growth factor-II (IGF-II) promotes cell proliferation and survival and plays an important role in normal fetal development and placental function. IGF-II binds both the insulin-like growth factor receptor (IGF-1R) and insulin
Externí odkaz:
https://doaj.org/article/f7a04f5cd3f64ab49ab50ddae8900dbf
Autor:
Jordan L. Pederick, Birgit I Gaiser, Nicholas C Schumann, Kate L. Wegener, Kwangjun Lee, James Hodgkinson-Bean, Steven W. Polyak, Thomas D. Avery, Grant W. Booker, John B. Bruning, Andrew D. Abell, Wanisa Salaemae, Andrew P. Thompson
Publikováno v:
ACS Chemical Biology. 16:2339-2347
Mycobacterium tuberculosis dethiobiotin synthase (MtDTBS) is a crucial enzyme involved in the biosynthesis of biotin in the causative agent of tuberculosis, M. tuberculosis. Here, we report a binder of MtDTBS, cyclopentylacetic acid 2 (KD = 3.4 ± 0.
Autor:
Nicholas C, Schumann, Kwang Jun, Lee, Andrew P, Thompson, Wanisa, Salaemae, Jordan L, Pederick, Thomas, Avery, Birgit I, Gaiser, James, Hodgkinson-Bean, Grant W, Booker, Steven W, Polyak, John B, Bruning, Kate L, Wegener, Andrew D, Abell
Publikováno v:
ACS chemical biology. 16(11)
Autor:
Kwangjun Lee, Andrew D. Abell, Steven W. Polyak, Beatriz Blanco-Rodriguez, John B. Bruning, Danielle Cini, Grant W. Booker, Robert W. Milne, Benjamin Noll, Andrew J. Hayes, Andrew C Marshall, Ashleigh S. Paparella, Jiage Feng, Matthew C.J. Wilce, Jingxian Yu, William Tieu
Publikováno v:
ACS Chemical Biology. 14:1990-1997
Here, we report the design, synthesis, and evaluation of a series of inhibitors of Staphylococcus aureus BPL (SaBPL), where the central acyl phosphate of the natural intermediate biotinyl-5′-AMP (1) is replaced by a sulfonamide isostere. Acylsulfam
Autor:
Tara L. Pukala, Andrew J. Hayes, Louise M. Sternicki, Keith E. Shearwin, Jiulia Satiaputra, Steven W. Polyak, Grant W. Booker
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports
An adequate supply of biotin is vital for the survival and pathogenesis of Staphylococcus aureus. The key protein responsible for maintaining biotin homeostasis in bacteria is the biotin retention protein A (BirA, also known as biotin protein ligase)
Publikováno v:
Acta Crystallographica Section D Structural Biology. 74:965-972
Dethiobiotin synthetase fromMycobacterium tuberculosis(MtDTBS) is a promising antituberculosis drug target. Small-molecule inhibitors that targetMtDTBS provide a route towards new therapeutics for the treatment of antibiotic-resistant tuberculosis. A
Autor:
Stephanie Nguyen, Nicole R. Pendini, Louise M. Sternicki, Grant W. Booker, Yoann Huet, Kate L. Wegener, Perdita E. Barran, Kamila J. Pacholarz, Tara L. Pukala, Steven W. Polyak, Rachel Baltz
Publikováno v:
Archives of biochemistry and biophysics. 691
Biotin protein ligase (BPL) is an essential enzyme in all kingdoms of life, making it a potential target for novel anti-infective agents. Whilst bacteria and archaea have simple BPL structures (class I and II), the homologues from certain eukaryotes
Autor:
Andrew J. Hayes, Beatriz Blanco-Rodriguez, Zikai Feng, Tara L. Pukala, Jiulia Satiaputra, Bart A. Eijkelkamp, Keith E. Shearwin, Louise M. Sternicki, Ashleigh S. Paparella, Kwang J. Lee, William Tieu, Andrew D. Abell, Grant W. Booker, Steven W. Polyak
Publikováno v:
Antibiotics, Vol 9, Iss 165, p 165 (2020)
Antibiotics
Volume 9
Issue 4
Antibiotics
Volume 9
Issue 4
Biotin protein ligase (BPL) inhibitors are a novel class of antibacterial that target clinically important methicillin-resistant Staphylococcus aureus (S. aureus). In S. aureus, BPL is a bifunctional protein responsible for enzymatic biotinylation of
Autor:
Wanida Phetsang, Mark A. T. Blaskovich, Zikai Feng, Ashleigh S. Paparella, Jiage Feng, Mark E. Cooper, Andrew D. Abell, Beatriz Blanco-Rodriguez, Grant W. Booker, Steven W. Polyak
Publikováno v:
Tetrahedron. 74:1175-1183
Inhibitors of biotin protein ligase (BPL) are novel antimicrobial compounds with the potential to treat infections caused by bacteria resistant to current antibiotics. A novel BPL inhibitor (12, Ki1.4 μM) was synthesized from biotin acetylene and an