Výsledky vyhledávání - "Grant T. Generaux"

In Vitro Modeling of Drug-Drug Interactions

Autor: Grant T. Generaux

Publikováno v: Drug Interactions in Infectious Diseases: Mechanisms and Models of Drug Interactions ISBN: 9783319724218

In vitro modeling of drug-drug interactions (DDI) has tremendous potential to impact the prediction and management of DDIs during the development of new anti-infective agents positively. In this chapter, two fundamental types of in vitro models used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58d3f76b5b18840f2b32c8d7a8f94ef0
https://doi.org/10.1007/978-3-319-72422-5_7

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Refining Liver Safety Risk Assessment:Application of Mechanistic Modeling and Serum Biomarkers to Cimaglermin Alfa (GGF2) Clinical Trials

Autor: Grant T. Generaux, Donald Button, Ric Stanulis, Anthony O. Caggiano, Brett A. Howell, Diane M. Longo, Merrie Mosedale, Daniel J. Antoine, Tom J. Parry, Paul B. Watkins, Andrew Eisen, Scott Q. Siler, Jennifer Iaci

Publikováno v: Longo, D M, Generaux, G T, Bengry-Howell, A, Siler, S Q, Antoine, D, Button, D, Caggiano, J A, Eisen, J A, Iaci, J, Stanulis, R, Parry, T, Mosedale, M & Watkins, P B 2017, ' Refining Liver Safety Risk Assessment : Application of Mechanistic Modeling and Serum Biomarkers to Cimaglermin Alfa (GGF2) Clinical Trials ', Clinical pharmacology and therapeutics, vol. 102, no. 6, pp. 961-969 . https://doi.org/10.1002/cpt.711
Clinical Pharmacology and Therapeutics

Cimaglermin alfa (GGF2) is a recombinant human protein growth factor in development for heart failure. Phase I trials were suspended when two cimaglermin alfa-treated subjects experienced concomitant elevations in serum aminotransferases and total bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd70ea640db5a0d3acd2dc98e1dfc91
https://www.pure.ed.ac.uk/ws/files/55790946/Antoine_D_Refining_Liver_Safety....pdf

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In Vitro Investigations into the Roles of Drug Transporters and Metabolizing Enzymes in the Disposition and Drug Interactions of Dolutegravir, a HIV Integrase Inhibitor

Autor: Paul M. Savina, Joseph W. Polli, Eri Kanaoka, Grant T. Generaux, James D. Clarke, Kelly A. Harmon, Helen Tracey, Melinda J. Reese, Joan E. Humphreys, Lindsey O. Webster

Publikováno v: Drug Metabolism and Disposition. 41:353-361

Dolutegravir (DTG; S/GSK1349572) is a potent HIV-1 integrase inhibitor with a distinct resistance profile and a once-daily dose regimen that does not require pharmacokinetic boosting. This work investigated the in vitro drug transport and metabolism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::993f8bf7610b57cb92f53b9a937dadea
https://doi.org/10.1124/dmd.112.048918

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Use of cassette dosing in sandwich-cultured rat and human hepatocytes to identify drugs that inhibit bile acid transport

Autor: Kim L. R. Brouwer, Joseph W. Polli, Grant T. Generaux, Sapana Vora, Kristina K. Wolf, Lindsey O. Webster

Publikováno v: Toxicology in Vitro. 24:297-309

Hepatocellular accumulation of bile acids due to inhibition of the canalicular bile salt export pump (BSEP/ABCB11) is one proposed mechanism of drug-induced liver injury (DILI). Some hepatotoxic compounds also are potent inhibitors of bile acid uptak

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71950041397695c888168ae77c63478f
https://doi.org/10.1016/j.tiv.2009.08.009

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An in Vitro Mechanistic Study to Elucidate the Desipramine/Bupropion Clinical Drug-Drug Interaction

Autor: Robert M. Wurm, Keith T. Muir, Lisa A St. John-Williams, Donavon J. McConn, Melinda J. Reese, Grant T. Generaux

Publikováno v: Drug Metabolism and Disposition. 36:1198-1201

There are documented clinical drug-drug interactions between bupropion and the CYP2D6-metabolized drug desipramine resulting in marked (5-fold) increases in desipramine exposure. This finding was unexpected as CYP2D6 does not play a significant role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817554c2d0e3b6e994ae64807c3eda5e
https://doi.org/10.1124/dmd.107.020198

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Impact of physiologically based pharmacokinetic modeling and simulation in drug development

Autor: Thuy Thanh Tran, Aarti H. Patel, Carole E. Shardlow, Jackie C. Bloomer, Guoying Tai, Grant T. Generaux

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 41(12)

Physiologically based pharmacokinetic modeling and simulation can be used to predict the pharmacokinetics of drugs in human populations and to explore the effects of varying physiologic parameters that result from aging, ethnicity, or disease. In add

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::050df73a5c4ad87d0a7120917cb3c47b
https://pubmed.ncbi.nlm.nih.gov/24009310

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Evaluation of drug interactions of GSK1292263 (a GPR119 agonist) with statins: from in vitro data to clinical study design

Autor: Mark A. Bush, David M. Collins, Glenn Smith, Nancy Turner, Derek J. Nunez, Susan L. McMullen, Elizabeth K. Hussey, Joseph W. Polli, Grant T. Generaux

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 43(6)

1. This work investigated the drug interaction potential of GSK1292263, a novel GPR119 agonist, with the HMG-coA reductase inhibitors simvastatin and rosuvastatin. 2. In vitro experiments assessed the inhibition of transporters and CYP enzymes by GSK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0b534d26e4d907e5cbb66b06c4c4cc5
https://pubmed.ncbi.nlm.nih.gov/23256625

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Utilizing drug-drug interaction prediction tools during drug development: enhanced decision making based on clinical risk

Autor: Konstantine W. Skordos, Grant T. Generaux, Christopher MacLauchlin, Nicoletta Pons, Jackie C. Bloomer, Carole Shardlow

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 39(11)

Several reports in the literature present the utility and value of in vitro drug-metabolizing enzyme inhibition data to predict in vivo drug-drug interactions in humans. A retrospective analysis has been conducted for 26 GlaxoSmithKline (GSK) drugs a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa4718e3bc95e4ef9a40bb81551168c2
https://pubmed.ncbi.nlm.nih.gov/21832001

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Impact of SLCO1B1 (OATP1B1) and ABCG2 (BCRP) genetic polymorphisms and inhibition on LDL-C lowering and myopathy of statins

Autor: Marta Johnson, Grant T. Generaux, Kelly M. Mahar Doan, Fiorenza M Bonomo

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 41(8)

Statins are the preferred class of drugs for treating patients with atherosclerosis and related coronary heart disease. Treatment with statins leads to significant low-density lipoprotein cholesterol (LDL-C) lowering, resulting in reductions in major

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba0702fc2dc1015ddc14699b3967fc46
https://pubmed.ncbi.nlm.nih.gov/21425956

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