Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Grant R Whitman"'
Autor:
Kelly M Hennessey, Ilse C Rogiers, Han-Wei Shih, Matthew A Hulverson, Ryan Choi, Molly C McCloskey, Grant R Whitman, Lynn K Barrett, Ethan A Merritt, Alexander R Paredez, Kayode K Ojo
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 8, p e0006673 (2018)
There is need for a more efficient cell-based assay amenable to high-throughput drug screening against Giardia lamblia. Here, we report the development of a screening method utilizing G. lamblia engineered to express red-shifted firefly luciferase. P
Externí odkaz:
https://doaj.org/article/7a29ec6e8e4b46608002ddb8fa8b679e
Autor:
Nicoleta Anghel, Dennis Imhof, Pablo Winzer, Vreni Balmer, Jessica Ramseier, Kai Haenggeli, Ryan Choi, Matthew A. Hulverson, Grant R. Whitman, Samuel L.M. Arnold, Kayode K. Ojo, Wesley C. Van Voorhis, J. Stone Doggett, Luis M. Ortega-Mora, Andrew Hemphill
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 17, Iss , Pp 92-106 (2021)
The apicomplexan parasite Neospora caninum is an important causative agent of congenital neosporosis, resulting in abortion, birth of weak offspring and neuromuscular disorders in cattle, sheep, and many other species. Among several compound classes
Externí odkaz:
https://doaj.org/article/d2ab6fc7c7674245a649097532f71673
Autor:
Roberto Sánchez-Sánchez, Ignacio Ferre, Michela Re, Bárbara Pérez-Arroyo, Darío Cleofé-Resta, Victor Herrero García, Manuel Pizarro Díaz, Luis Miguel Ferrer, Hector Ruiz, Raquel Vallejo-García, Julio Benavides, Matthew A. Hulverson, Ryan Choi, Grant R. Whitman, Andrew Hemphill, Wesley C. Van Voorhis, Luis Miguel Ortega-Mora
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 17, Iss , Pp 176-185 (2021)
The Neospora caninum Calcium-dependent protein kinase 1 (NcCDPK1) inhibitor BKI-1294 had demonstrated excellent efficacy in a pregnant mouse model of neosporosis, and was also highly efficacious in a pregnant sheep model of toxoplasmosis. In this wor
Externí odkaz:
https://doaj.org/article/b6c94e734a27405cab3b51361d75d0f2
Autor:
Dennis Imhof, Nicoleta Anghel, Pablo Winzer, Vreni Balmer, Jessica Ramseier, Kai Hänggeli, Ryan Choi, Matthew A. Hulverson, Grant R. Whitman, Samuel L.M. Arnold, Kayode K. Ojo, Wesley C. Van Voorhis, J. Stone Doggett, Luis M. Ortega-Mora, Andrew Hemphill
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 16, Iss , Pp 90-101 (2021)
Bumped kinase inhibitors (BKIs) target the apicomplexan calcium-dependent protein kinase 1 (CDPK1). BKI-1748, a 5-aminopyrazole-4-carboxamide compound when added to fibroblast cells concomitantly to the time of infection, inhibited proliferation of a
Externí odkaz:
https://doaj.org/article/225361d65821483fab18631218d65033
Autor:
Aruna Shrestha, Bärbel Ruttkowski, Patricia Greber, Grant R. Whitman, Matthew A. Hulverson, Ryan Choi, Samantha A. Michaels, Kayode K. Ojo, Wesley C. Van Voorhis, Anja Joachim
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 14, Iss , Pp 37-45 (2020)
Bumped kinase inhibitors (BKIs) are a new class of antiprotozoal drugs that target calcium-dependent protein kinase 1 (CDPK1) in various apicomplexan parasites. A multiple dose regimen of BKI 1369 has been shown to be highly effective against Cystois
Externí odkaz:
https://doaj.org/article/47c64fc23a0a49e6a8eeda0305a2aee7
Autor:
Matthew A. Hulverson, Ryan Choi, Deborah A. Schaefer, Dana P. Betzer, Molly C. McCloskey, Grant R. Whitman, Wenlin Huang, Sangun Lee, Andy Pranata, Malcolm D. McLeod, Kennan C. Marsh, Dale J. Kempf, Bruce E. LeRoy, Mark T. Zafiratos, Aimee L. Bielinski, Robert C. Hackman, Kayode K. Ojo, Samuel L. M. Arnold, Lynn K. Barrett, Saul Tzipori, Michael W. Riggs, Erkang Fan, Wesley C. Van Voorhis
Publikováno v:
Antimicrobial Agents and Chemotherapy. 67
Recent advances on the development of bumped kinase inhibitors for treatment of cryptosporidiosis have focused on the 5-aminopyrazole-4-carboxamide scaffold, due to analogs that have less hERG inhibition, superior efficacy, and strong in vitro safety
Autor:
Dennis Imhof, Jessica Ramseier, Wesley C. Van Voorhis, Andrew Hemphill, Samuel L.M. Arnold, Grant R. Whitman, Vreni Balmer, J. Stone Doggett, Matthew A. Hulverson, Ryan Choi, Kayode K. Ojo, Pablo Winzer, Luis Miguel Ortega-Mora, Kai Haenggeli, Nicoleta Anghel
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 17, Iss, Pp 92-106 (2021)
Anghel, Nicoleta; Imhof, Dennis; Winzer, Pablo; Balmer, Vreni; Ramseier, Jessica; Haenggeli, Kai; Choi, Ryan; Hulverson, Matthew A; Whitman, Grant R; Arnold, Samuel L M; Ojo, Kayode K; Van Voorhis, Wesley C; Doggett, J Stone; Ortega-Mora, Luis M; Hemphill, Andrew (2021). Endochin-like quinolones (ELQs) and bumped kinase inhibitors (BKIs): Synergistic and additive effects of combined treatments against Neospora caninum infection in vitro and in vivo. International journal for parasitology. Drugs and drug resistance, 17, pp. 92-106. Elsevier 10.1016/j.ijpddr.2021.08.007
International Journal for Parasitology: Drugs and Drug Resistance
Anghel, Nicoleta; Imhof, Dennis; Winzer, Pablo; Balmer, Vreni; Ramseier, Jessica; Haenggeli, Kai; Choi, Ryan; Hulverson, Matthew A; Whitman, Grant R; Arnold, Samuel L M; Ojo, Kayode K; Van Voorhis, Wesley C; Doggett, J Stone; Ortega-Mora, Luis M; Hemphill, Andrew (2021). Endochin-like quinolones (ELQs) and bumped kinase inhibitors (BKIs): Synergistic and additive effects of combined treatments against Neospora caninum infection in vitro and in vivo. International journal for parasitology. Drugs and drug resistance, 17, pp. 92-106. Elsevier 10.1016/j.ijpddr.2021.08.007
International Journal for Parasitology: Drugs and Drug Resistance
The apicomplexan parasite Neospora caninum is an important causative agent of congenital neosporosis, resulting in abortion, birth of weak offspring and neuromuscular disorders in cattle, sheep, and many other species. Among several compound classes
Autor:
Adrienne E. Shapiro, Alaina M. Olson, Lara Kidoguchi, Xin Niu, Zinhle Ngcobo, Zanele P. Magcaba, Mduduzi W. Ngwane, Grant R. Whitman, Kris M. Weigel, Rachel C. Wood, Doug P. K. Wilson, Paul K. Drain, Gerard A. Cangelosi
Publikováno v:
J Clin Microbiol
Testing for mycobacterial lipoarabinomannan (LAM) in urine is a practical but insensitive alternative to sputum testing to diagnose tuberculosis (TB) in people with HIV (PWH). Here, we evaluated urine LAM testing alongside PCR-based tests for Mycobac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c697a96823814565c8be0ca5c7685a8b
Autor:
Samantha A. Michaels, Matthew A. Hulverson, Grant R. Whitman, Linh T. Tran, Ryan Choi, Erkang Fan, Case W. McNamara, Melissa S. Love, Kayode K. Ojo
Publikováno v:
Antimicrobial Agents and Chemotherapy. 66
A phenotypic screen of the ReFRAME compound library was performed to identify cell-active inhibitors that could be developed as therapeutics for giardiasis. A primary screen against Giardia lamblia GS clone H7 identified 85 cell-active compounds at a
Autor:
Adrienne E. Shapiro, Alaina M. Olson, Lara Kidoguchi, Xin Niu, Zinhle Ngcobo, Zanele P. Magcaba, Mduduzi W. Ngwane, Grant R. Whitman, Kris M. Weigel, Rachel C. Wood, Doug P.K. Wilson, Paul K. Drain, Gerard A. Cangelosi
Testing for mycobacterial lipoarabinomannan (LAM) in urine is a practical but insensitive alternative to sputum testing to diagnose tuberculosis (TB) in people with HIV (PWH). We evaluated urine LAM testing conducted in parallel with tests for Mycoba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::674d4c6aac28805194285b9c4ffb5a78
https://doi.org/10.1101/2022.02.16.22271079
https://doi.org/10.1101/2022.02.16.22271079