Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Grant R MacGregor"'
Autor:
Amber R. Syage, Collin Pachow, Kaitlin M. Murray, Caden Henningfield, Kellie Fernandez, Annie Du, Yuting Cheng, Gema Olivarria, Shimako Kawauchi, Grant R. MacGregor, Kim N. Green, Thomas E. Lane
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-17 (2024)
Abstract Background Cystatin F is a secreted lysosomal cysteine protease inhibitor that has been implicated in affecting the severity of demyelination and enhancing remyelination in pre-clinical models of immune-mediated demyelination. How cystatin F
Externí odkaz:
https://doaj.org/article/4a55b008696d4b3da83e22a11f3d6e46
Autor:
Yu-Han Chen, Albert P. Ta, Yumay Chen, Hsiao-Chen Lee, Wenjun Fan, Phang-Lang Chen, Maria C. Jordan, Kenneth P. Roos, Grant R. MacGregor, Qin Yang, Robert A. Edwards, Junfeng Li, Ping H. Wang
Publikováno v:
Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-20 (2023)
Abstract Background The PI3K/AKT pathway transduces the majority of the metabolic actions of insulin. In addition to cytosolic targets, insulin-stimulated phospho-AKT also translocates to mitochondria in the myocardium. Mouse models of diabetes exhib
Externí odkaz:
https://doaj.org/article/b8f23794a64c483a9bcc037647b58465
Autor:
Kristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine S. Sakr, Angela Gomez-Arboledas, Miguel A. Arreola, Celia da Cunha, Jimmy Phan, Shuling Wang, Sherilyn Collins, Amber Walker, Kai-Xuan Shi, Jonathan Neumann, Ghassan Filimban, Zechuan Shi, Giedre Milinkeviciute, Dominic I. Javonillo, Katelynn Tran, Magdalena Gantuz, Stefania Forner, Vivek Swarup, Andrea J. Tenner, Frank M. LaFerla, Marcelo A. Wood, Ali Mortazavi, Grant R. MacGregor, Kim N. Green
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-26 (2023)
Abstract Background The TREM2 R47H variant is one of the strongest genetic risk factors for late-onset Alzheimer’s Disease (AD). Unfortunately, many current Trem2 R47H mouse models are associated with cryptic mRNA splicing of the mutant allele that
Externí odkaz:
https://doaj.org/article/7cc752a4e65d4dbe841fd116a51289c8
Autor:
Stefania Forner, Shimako Kawauchi, Gabriela Balderrama-Gutierrez, Enikö A. Kramár, Dina P. Matheos, Jimmy Phan, Dominic I. Javonillo, Kristine M. Tran, Edna Hingco, Celia da Cunha, Narges Rezaie, Joshua A. Alcantara, David Baglietto-Vargas, Camden Jansen, Jonathan Neumann, Marcelo A. Wood, Grant R. MacGregor, Ali Mortazavi, Andrea J. Tenner, Frank M. LaFerla, Kim N. Green
Publikováno v:
Scientific Data, Vol 8, Iss 1, Pp 1-16 (2021)
Measurement(s) Protein Expression • gene expression • electrophysiology data • protein measurement • behavior Technology Type(s) immunofluorescence microscopy assay • RNA sequencing • electrophysiology assay • Electrochemiluminescence I
Externí odkaz:
https://doaj.org/article/b2396bfe67d3413cbec4c74a4d952aef
Autor:
David Baglietto-Vargas, Stefania Forner, Lena Cai, Alessandra C. Martini, Laura Trujillo-Estrada, Vivek Swarup, Marie Minh Thu Nguyen, Kelly Do Huynh, Dominic I. Javonillo, Kristine Minh Tran, Jimmy Phan, Shan Jiang, Enikö A. Kramár, Cristina Nuñez-Diaz, Gabriela Balderrama-Gutierrez, Franklin Garcia, Jessica Childs, Carlos J. Rodriguez-Ortiz, Juan Antonio Garcia-Leon, Masashi Kitazawa, Mohammad Shahnawaz, Dina P. Matheos, Xinyi Ma, Celia Da Cunha, Ken C. Walls, Rahasson R. Ager, Claudio Soto, Antonia Gutierrez, Ines Moreno-Gonzalez, Ali Mortazavi, Andrea J. Tenner, Grant R. MacGregor, Marcelo Wood, Kim N. Green, Frank M. LaFerla
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Most instances of Alzheimer’s disease (AD) are sporadic or not associated with a particular mutation. Here, the authors develop knock-in mice that express wildtype human Aβ under control of the mouse App locus, which may have potential for modelli
Externí odkaz:
https://doaj.org/article/1e311a8bbdd34a96bb987b252f4dfaaf
Autor:
Dominic I. Javonillo, Kristine M. Tran, Jimmy Phan, Edna Hingco, Enikö A. Kramár, Celia da Cunha, Stefania Forner, Shimako Kawauchi, Giedre Milinkeviciute, Angela Gomez-Arboledas, Jonathan Neumann, Crystal E. Banh, Michelle Huynh, Dina P. Matheos, Narges Rezaie, Joshua A. Alcantara, Ali Mortazavi, Marcelo A. Wood, Andrea J. Tenner, Grant R. MacGregor, Kim N. Green, Frank M. LaFerla
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2022)
Animal models of disease are valuable resources for investigating pathogenic mechanisms and potential therapeutic interventions. However, for complex disorders such as Alzheimer’s disease (AD), the generation and availability of innumerous distinct
Externí odkaz:
https://doaj.org/article/677dc4105eff49cab8550eb3df2b59bd
Autor:
Adrian L. Oblak, Stefania Forner, Paul R. Territo, Michael Sasner, Gregory W. Carter, Gareth R. Howell, Stacey J. Sukoff‐Rizzo, Benjamin A. Logsdon, Lara M. Mangravite, Ali Mortazavi, David Baglietto‐Vargas, Kim N. Green, Grant R. MacGregor, Marcelo A. Wood, Andrea J. Tenner, Frank M. LaFerla, Bruce T. Lamb, and The MODEL‐AD, Consortium
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)
Abstract Alzheimer's disease (AD) is a major cause of dementia, disability, and death in the elderly. Despite recent advances in our understanding of the basic biological mechanisms underlying AD, we do not know how to prevent it, nor do we have an a
Externí odkaz:
https://doaj.org/article/82d8538d9c6f4b1592fcdc36f7060ab7
Autor:
Katelynn Tran, Giedre Milinkeviciute, Kristine M Tran, Jimmy Phan, Celia Da Cunha, Dominic I Javonillo, Shimako Kawauchi, Andrea J Tenner, Frank LaFerla, Grant R MacGregor, Kim N Green
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1172c80a3e2235fb91ae6d75e5306b42
https://doi.org/10.1002/alz.066218
https://doi.org/10.1002/alz.066218
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49e1b1ceb2bc548fd8af988543df0806
https://doi.org/10.1002/alz.062641
https://doi.org/10.1002/alz.062641
Autor:
Kristine M Tran, Shimako Kawauchi, Dominic I Javonillo, Celia Da Cunha, Jimmy Phan, Narges Rezaie, Heidi Yahan Liang, Giedre Milinkeviciute, Angela Gomez‐Arboledas, Stefania Forner, Ali Mortazavi, Andrea J Tenner, Frank LaFerla, Grant R MacGregor, Kim N Green
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dcc56abdada82338f23593659919525
https://doi.org/10.1002/alz.062610
https://doi.org/10.1002/alz.062610