Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Grant P. Higerd-Rusli"'
Autor:
Sidharth Tyagi, Grant P. Higerd-Rusli, Mohammad-Reza Ghovanloo, Fadia Dib-Hajj, Peng Zhao, Shujun Liu, Dong-Hyun Kim, Ji Seon Shim, Kang-Sik Park, Stephen G. Waxman, Jin-Sung Choi, Sulayman D. Dib-Hajj
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113685- (2024)
Summary: Tumor necrosis factor α (TNF-α) is a major pro-inflammatory cytokine, important in many diseases, that sensitizes nociceptors through its action on a variety of ion channels, including voltage-gated sodium (NaV) channels. We show here that
Externí odkaz:
https://doaj.org/article/fd5e2249aa9a4d75bd40c729fcbfa8f5
Autor:
Sidharth Tyagi, Nivedita Sarveswaran, Grant P. Higerd-Rusli, Shujun Liu, Fadia B. Dib-Hajj, Stephen G. Waxman, Sulayman D. Dib-Hajj
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Non-addictive treatment of chronic pain represents a major unmet clinical need. Peripheral voltage-gated sodium (NaV) channels are an attractive target for pain therapy because they initiate and propagate action potentials in primary afferents that d
Externí odkaz:
https://doaj.org/article/a0ecf55f00dd4bc59cf9e51a8896351e
Autor:
Christopher A. Baker, Sidharth Tyagi, Grant P. Higerd-Rusli, Shujun Liu, Peng Zhao, Fadia B. Dib-Hajj, Stephen G. Waxman, Sulayman D. Dib-Hajj
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Patients treated with paclitaxel (PTX) or other antineoplastic agents can experience chemotherapy-induced peripheral neuropathy (CIPN), a debilitating side effect characterized by numbness and pain. PTX interferes with microtubule-based transport, wh
Externí odkaz:
https://doaj.org/article/170451ae54c8419e85075d48c02f370f
Autor:
Grant P. Higerd-Rusli, Sidharth Tyagi, Christopher A. Baker, Shujun Liu, Fadia B. Dib-Hajj, Sulayman D. Dib-Hajj, Stephen G. Waxman
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Inflammation causes pain by shifting the balance of ionic currents in nociceptors toward depolarization, leading to hyperexcitability. The ensemble of ion channels within the plasma membrane is regulated by processes including biogenesis, transport,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1ab653c0d16e78ee608305c1a38a3ce
https://doi.org/10.1073/pnas.2215417120
https://doi.org/10.1073/pnas.2215417120
Autor:
Grant P. Higerd-Rusli, Matthew Alsaloum, Sidharth Tyagi, Nivedita Sarveswaran, Mark Estacion, Elizabeth J. Akin, Fadia B. Dib-Hajj, Shujun Liu, Daniel Sosniak, Peng Zhao, Sulayman D. Dib-Hajj, Stephen G. Waxman
Publikováno v:
J Neurosci
Neuronal excitability relies on coordinated action of functionally distinction channels. Voltage-gated sodium (Na(V)) and potassium (K(V)) channels have distinct but complementary roles in firing action potentials: Na(V) channels provide depolarizing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e80baa72b564e553d5b3b7cb4fe9b398
https://europepmc.org/articles/PMC9188389/
https://europepmc.org/articles/PMC9188389/
Autor:
Grant P, Higerd-Rusli, Sidharth, Tyagi, Shujun, Liu, Fadia B, Dib-Hajj, Stephen G, Waxman, Sulayman D, Dib-Hajj
Publikováno v:
The Journal of biological chemistry.
Neuronal function relies on the maintenance of appropriate levels of various ion channels at the cell membrane, which is accomplished by balancing secretory, degradative, and recycling pathways. Neuronal function further depends on membrane specializ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::06c20b1c829ead6333c52428df5c0c33
https://pubmed.ncbi.nlm.nih.gov/36539035
https://pubmed.ncbi.nlm.nih.gov/36539035
Autor:
Grant P. Higerd-Rusli, Sidharth Tyagi, Shujun Liu, Fadia B. Dib-Hajj, Stephen G. Waxman, Sulayman D. Dib-Hajj
Publikováno v:
Journal of Biological Chemistry. 299:102816
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a13e8612659ce514d009da5286de685a
https://doi.org/10.1016/j.jbc.2022.102816
https://doi.org/10.1016/j.jbc.2022.102816