Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Grant P Parnell"'
Publikováno v:
Clinical & Translational Immunology, Vol 12, Iss 6, Pp n/a-n/a (2023)
Abstract Multiple sclerosis (MS) is a chronic neurodegenerative autoimmune disease, characterised by the demyelination of neurons in the central nervous system. Whilst it is unclear what precisely leads to MS, it is believed that genetic predispositi
Externí odkaz:
https://doaj.org/article/90bf01d7599b49fb89161bce59747d7a
Autor:
Jake W. Rhodes, Rachel A. Botting, Kirstie M. Bertram, Erica E. Vine, Hafsa Rana, Heeva Baharlou, Peter Vegh, Thomas R. O’Neil, Anneliese S. Ashhurst, James Fletcher, Grant P. Parnell, J. Dinny Graham, Najla Nasr, Jake J. K. Lim, Laith Barnouti, Peter Haertsch, Martijn P. Gosselink, Angelina Di Re, Faizur Reza, Grahame Ctercteko, Gregory J. Jenkins, Andrew J. Brooks, Ellis Patrick, Scott N. Byrne, Eric Hunter, Muzlifah A. Haniffa, Anthony L. Cunningham, Andrew N. Harman
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Epithelial tissue mononuclear phagocytes (MNP) can transmit HIV to CD4 T cells, but less is known about sub-epithelial cells. Here, the authors describe MNPs in human anogenital and colorectal tissues and find that CD14+CD1c+ monocyte-derived dendrit
Externí odkaz:
https://doaj.org/article/3840bd9c9273487999b88e2c53427e0d
Autor:
Benjamin M. Tang, Maryam Shojaei, Sally Teoh, Adrienne Meyers, John Ho, T. Blake Ball, Yoav Keynan, Amarnath Pisipati, Aseem Kumar, Damon P. Eisen, Kevin Lai, Mark Gillett, Rahul Santram, Robert Geffers, Jens Schreiber, Khyobeni Mozhui, Stephen Huang, Grant P. Parnell, Marek Nalos, Monika Holubova, Tracy Chew, David Booth, Anand Kumar, Anthony McLean, Klaus Schughart
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Identification of host factors associated with severe influenza infection could provide insights into treatment options. Here, the authors provide transcriptomic analyses of blood from >100 influenza infected patients and show that changes in circula
Externí odkaz:
https://doaj.org/article/f8717f61b4914b2fa628be04cd6755a4
Autor:
Ali Afrasiabi, Grant P. Parnell, Nicole Fewings, Stephen D. Schibeci, Monica A. Basuki, Ramya Chandramohan, Yuan Zhou, Bruce Taylor, David A. Brown, Sanjay Swaminathan, Fiona C. McKay, Graeme J. Stewart, David R. Booth
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-13 (2019)
Abstract Background Genome wide association studies have identified > 200 susceptibility loci accounting for much of the heritability of multiple sclerosis (MS). Epstein-Barr virus (EBV), a memory B cell tropic virus, has been identified as necessary
Externí odkaz:
https://doaj.org/article/6dd9c48e50fe4d28bccc98bc12d1082e
Autor:
Timothy E. Sweeney, Thanneer M. Perumal, Ricardo Henao, Marshall Nichols, Judith A. Howrylak, Augustine M. Choi, Jesús F. Bermejo-Martin, Raquel Almansa, Eduardo Tamayo, Emma E. Davenport, Katie L. Burnham, Charles J. Hinds, Julian C. Knight, Christopher W. Woods, Stephen F. Kingsmore, Geoffrey S. Ginsburg, Hector R. Wong, Grant P. Parnell, Benjamin Tang, Lyle L. Moldawer, Frederick E. Moore, Larsson Omberg, Purvesh Khatri, Ephraim L. Tsalik, Lara M. Mangravite, Raymond J. Langley
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Sepsis is characterized by deregulated host response to infection. Efficient therapies are still needed but a limitation for sepsis treatment is the heterogeneity in patients. Here Sweeney et al. generate prognostic models based on gene expression to
Externí odkaz:
https://doaj.org/article/87658db7864648bb930cc04d02ab688a
Autor:
David Brown, Prudence N. Gatt, Graeme J. Stewart, Steve Vucic, Fiona C. McKay, Christopher Liddle, Samantha P L Law, Scott N. Byrne, Prue H. Hart, David R. Booth, Stephen D. Schibeci, Grant P Parnell
Publikováno v:
Genes and Immunity
Although genetic and epidemiological evidence indicates vitamin D insufficiency contributes to multiple sclerosis (MS), and serum levels of vitamin D increase on treatment with cholecalciferol, recent metanalyses indicate that this vitamin D form doe
Age-dependent VDR peak DNA methylation as a mechanism for latitude-dependent multiple sclerosis risk
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-12 (2021)
Epigenetics & Chromatin
Epigenetics & Chromatin
BackgroundThe mechanisms linking UV radiation and vitamin D exposure to the risk of acquiring the latitude and critical period-dependent autoimmune disease, multiple sclerosis, is unclear. We examined the effect of vitamin D on DNA methylation and DN
Autor:
Jeremy T. Keane, Ali Afrasiabi, Stephen D. Schibeci, Nicole Fewings, Grant P. Parnell, Sanjay Swaminathan, David R. Booth
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
Multiple Sclerosis (MS) is a complex immune-mediated disease of the central nervous system. Treatment is based on immunomodulation, including specifically targeting B cells. B cells are the main host for the Epstein-Barr Virus (EBV), which has been d
Publikováno v:
Contact Lens and Anterior Eye. 45:101494
Purpose To determine if there is diurnal variation in gene expression in normal healthy conjunctival cells. Methods Bulbar conjunctival swab samples were collected from four healthy subjects in the morning and evening of the same day. The two swab sa
Autor:
Sanjay Swaminathan, Grant P Parnell, Graeme J. Stewart, Lawrence T C Ong, Ali Afrasiabi, David R. Booth
Publikováno v:
Genes and Immunity
Epstein–Barr Virus (EBV) infection appears to be necessary for the development of Multiple Sclerosis (MS), although the specific mechanisms are unknown. More than 200 single-nucleotide polymorphisms (SNPs) are known to be associated with the risk o