Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Grant Masson"'
Autor:
Nikole J. Byrne, BSc, Nirmal Parajuli, PhD, Jody L. Levasseur, BSc, Jamie Boisvenue, BTech, Donna L. Beker, Grant Masson, BSc, Paul W.M. Fedak, MD, PhD, Subodh Verma, MD, PhD, Jason R.B. Dyck, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 2, Iss 4, Pp 347-354 (2017)
This study sought to determine whether the sodium/glucose cotransporter 2 (SGLT2) inhibitor empagliflozin improved heart failure (HF) outcomes in nondiabetic mice. The EMPA-REG OUTCOME (Empagliflozin, Cardiovascular Outcome Event Trial in Type 2 Diab
Externí odkaz:
https://doaj.org/article/b8f761721afe4ce8a10d25385c71df66
Autor:
Grant Masson, Nirmal Parajuli, Donna L. Beker, Subodh Verma, Jason R.B. Dyck, Jamie Boisvenue, Nikole J. Byrne, Jody Levasseur, Paul W.M. Fedak
Publikováno v:
JACC: Basic to Translational Science, Vol 2, Iss 4, Pp 347-354 (2017)
JACC: Basic to Translational Science
JACC: Basic to Translational Science
Visual Abstract
Highlights • Although empagliflozin markedly reduces heart failure and cardiovascular-related deaths in diabetic patients, whether empagliflozin improves cardiac outcomes in the absence of diabetes is unknown. • Nondiabetic m
Highlights • Although empagliflozin markedly reduces heart failure and cardiovascular-related deaths in diabetic patients, whether empagliflozin improves cardiac outcomes in the absence of diabetes is unknown. • Nondiabetic m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4751d155b68f8527d032991caaa42452
http://www.sciencedirect.com/science/article/pii/S2452302X17301481
http://www.sciencedirect.com/science/article/pii/S2452302X17301481
Autor:
Ian M. Robertson, Carrie-Lynn M. Soltys, Donna L. Beker, Jason R.B. Dyck, Grant Masson, Miranda M. Sung, Shereen M. Hamza, Nobutoshi Matsumura
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 312:H561-H570
Since left ventricular hypertrophy (LVH) increases the susceptibility for the development of other cardiac conditions, pharmacotherapy that mitigates pathological cardiac remodeling may prove to be beneficial in patients with LVH. Previous work has s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab651e6169d873e57deafad612f38400
https://doi.org/10.1152/ajpheart.00604.2016
https://doi.org/10.1152/ajpheart.00604.2016
Autor:
Jamie Boisvenue, Ty T. Kim, Jason R.B. Dyck, Nikole J. Byrne, Jody Levasseur, Maria Febbraio, Miranda M. Sung, Grant Masson
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 312:H552-H560
Previous studies have shown that loss of CD36 protects the heart from dysfunction induced by pressure overload in the presence of diet-induced insulin resistance and/or obesity. The beneficial effects of CD36 ablation in this context are mediated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b931c82fdb682876dc3ae1de2fe71bc
https://doi.org/10.1152/ajpheart.00626.2016
https://doi.org/10.1152/ajpheart.00626.2016
Autor:
Grant Masson, David S. Wishart, Shereen M. Hamza, Heekuk Park, Karen L. Madsen, Ty T. Kim, Jason R.B. Dyck, Jonathan D. Schertzer, Nikole J. Byrne, Carrie-Lynn M. Soltys, Miranda M. Sung, Emmanuel Denou
Publikováno v:
Diabetes. 66:418-425
Oral administration of resveratrol is able to improve glucose homeostasis in obese individuals. Herein we show that resveratrol ingestion produces taxonomic and predicted functional changes in the gut microbiome of obese mice. In particular, changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e7eaf86f515d5e4957c7f5f70019ba
https://doi.org/10.2337/db16-0680
https://doi.org/10.2337/db16-0680
Autor:
Keshav Gopal, Malak Almutairi, Zeruesenay Desta, Bruno Saleme, Megan E. Capozzi, Jason R.B. Dyck, Farah Eaton, Jingjing Niu, Grant Masson, Gopinath Sutendra, Léa Garneau, Andrea R. Masters, Nikole J. Byrne, Ryekjang Kim, Carlos A. Velázquez-Martínez, Jonathan E. Campbell, Amanda A. Greenwell, S. Amirhossein Tabatabaei-Dakhili, John R. Ussher, Erin E. Mulvihill, Céline Aguer, Jadin J. Chahade, Peter A. Crawford, Rami Al Batran
Publikováno v:
Cell Metabolism. 31:909-919.e8
Perturbations in carbohydrate, lipid, and protein metabolism contribute to obesity-induced type 2 diabetes (T2D), though whether alterations in ketone body metabolism influence T2D pathology is unknown. We report here that activity of the rate-limiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5c9b3ef5447f7636a6132c728b8b171
https://doi.org/10.1016/j.cmet.2020.03.017
https://doi.org/10.1016/j.cmet.2020.03.017
Autor:
Nobutoshi Matsumura, Grant Masson, Sherif M. Shoieb, Nirmal Parajuli, Zaid H. Maayah, Donna L. Beker, Shingo Takahara, Jason R.B. Dyck, Nikole J. Byrne, Carrie-Lynn M. Soltys, Ayman O.S. El-Kadi
Publikováno v:
Journal of molecular and cellular cardiology. 125
Numerous epidemiological studies have demonstrated that approximately 40% of myocardial infarctions (MI) are associated with heart failure (HF). Resveratrol, a naturally occurring polyphenol, has been shown to be beneficial in the treatment of MI-ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919a67579cf311f0713be0fc1dbe172b
https://pubmed.ncbi.nlm.nih.gov/30381233
https://pubmed.ncbi.nlm.nih.gov/30381233
Autor:
Wang Wang, Grant Masson, Jason R.B. Dyck, Gavin Y. Oudit, Pavel Zhabyeyev, Petra C. Kienesberger, Brent A. McLean
Publikováno v:
Journal of Molecular and Cellular Cardiology. 54:9-18
Classical ischemia–reperfusion (IR) preconditioning relies on phosphatidylinositol 3-kinase (PI3K) for protective signaling. Surprisingly, inhibition of PI3Kα activity using a dominant negative (DN) strategy protected the murine heart from IR inju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92a65220ce0dd952ec7bd53adbfe5011
https://doi.org/10.1016/j.yjmcc.2012.10.015
https://doi.org/10.1016/j.yjmcc.2012.10.015
Publikováno v:
Journal of Molecular Medicine. 89:291-302
Recent evidence has suggested that activation of AMP-activated protein kinase (AMPK) induced by short-term caloric restriction (CR) protects against myocardial ischemia-reperfusion (I/R) injury. Because AMPK plays a central role in regulating energy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adead2c322058fefdd7179a94489a992
https://doi.org/10.1007/s00109-010-0703-5
https://doi.org/10.1007/s00109-010-0703-5
Autor:
Grant Masson, Jason R.B. Dyck, Martin E. Young, Jody Levasseur, Jamie Boisvenue, Nikole J. Byrne, Miranda M. Sung
Publikováno v:
Cardiovascular Research
Aims Impaired cardiac substrate metabolism plays an important role in heart failure (HF) pathogenesis. Since many of these metabolic changes occur at the transcriptional level of metabolic enzymes, it is possible that this loss of metabolic flexibili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56cbe5f2864f1fabdbe1e879fd47c8f2
https://pubmed.ncbi.nlm.nih.gov/26968698
https://pubmed.ncbi.nlm.nih.gov/26968698