Výsledky vyhledávání - "Grant M. Kelly"

EP3 signaling is decoupled from regulation of glucose-stimulated insulin secretion in β-cells compensating for obesity and insulin resistance

Autor: Michelle E. Kimple, Matthew J. Merrins, Jeffrey M. Harrington, Sophia M. Sdao, Grant M. Kelly, Michael D. Schaid

Of the β-cell signaling pathways altered by non-diabetic obesity and insulin resistance, some are adaptive while others actively contribute to β-cell failure and demise. Cytoplasmic calcium (Ca2+) and cyclic AMP (cAMP), which control the timing and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e6625b5fd5e81d2c3606cb83d96687a
https://doi.org/10.1101/2020.07.10.197863

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Differential Regulation of β‐cell Function by Tonically‐active and Receptor‐activated Gα z : Implications for β‐cell Compensation and Failure

Autor: Jeff Harrington, Grant M. Kelly, Kathyrn Carbajal, Michael D. Schaid, Michelle E. Kimple

Publikováno v: The FASEB Journal. 33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f6156bb62a156b0a571f8c413f038b6
https://doi.org/10.1096/fasebj.2019.33.1_supplement.514.15

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Agonist-independent Gαz activity negatively regulates beta-cell compensation in a diet-induced obesity model of type 2 diabetes

Autor: Grant M. Kelly, Kathryn A. Carbajal, Dudley W. Lamming, Michelle E. Kimple, Erin Guthery, Shannon J. Gallagher, Allison L. Brill, Joshua C. Neuman, Darby C. Peter, Cara L Green, Molly L. Wehner, Michael D. Schaid, Austin Reuter, Jeffrey M. Harrington

Publikováno v: The Journal of Biological Chemistry

The inhibitory G protein alpha-subunit (Gαz) is an important modulator of beta-cell function. Full-body Gαz-null mice are protected from hyperglycemia and glucose intolerance after long-term high-fat diet (HFD) feeding. In this study, at a time poi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d299e7f361025fcb5f8c430f86202b
https://doi.org/10.1074/jbc.ra120.015585

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Loss of β‐cell Gα z protects against high‐fat diet induced glucose intolerance by preserving incretin responsiveness and enhancing insulin secretion

Autor: Molly L. Wehner, Jeffrey M. Harrington, Michael D. Schaid, Grant M. Kelly, Rachel J. Fenske, Austin Reuter, Erin Laundre, Dudley W. Lamming, Kathryn A. Carbajal, Michelle E. Kimple, Cara L Green

Publikováno v: The FASEB Journal. 34:1-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::772b903880bb9c4e0340fc904d19d741
https://doi.org/10.1096/fasebj.2020.34.s1.04098

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