Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Grant J Logan"'
Autor:
Renuka Rao, Melad Farraha, Grant J. Logan, Sindhu Igoor, Cindy Y. Kok, James J. H. Chong, Ian E. Alexander, Eddy Kizana
Publikováno v:
Viruses, Vol 14, Iss 8, p 1623 (2022)
Gene therapy is making significant impact on a modest, yet growing, number of human diseases. Justifiably, the preferred viral vector for clinical use is that based on recombinant adeno-associated virus (rAAV). There is a need to scale up rAAV vector
Externí odkaz:
https://doaj.org/article/c6b92e3910324c8c82f7a25586622cd6
Autor:
Samantha L. Ginn, Anais K. Amaya, Sophia H.Y. Liao, Erhua Zhu, Sharon C. Cunningham, Michael Lee, Claus V. Hallwirth, Grant J. Logan, Szun S. Tay, Anthony J. Cesare, Hilda A. Pickett, Markus Grompe, Kimberley Dilworth, Leszek Lisowski, Ian E. Alexander
Publikováno v:
JHEP Reports, Vol 2, Iss 1, Pp - (2020)
Background & Aims: Genome editing technology has immense therapeutic potential and is likely to rapidly supplant contemporary gene addition approaches. Key advantages include the capacity to directly repair mutant loci with resultant recovery of phys
Externí odkaz:
https://doaj.org/article/81b618aa4be6420b93bda12009cd595b
Autor:
Castorina, Jayden Lee, Sarah Thomas Broome, Margo Iris Jansen, Mawj Mandwie, Grant J. Logan, Rubina Marzagalli, Giuseppe Musumeci, Alessandro
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 11118
Neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the most common and severe manifestations of lupus; however, its pathogenesis is still poorly understood. While there is sparse evidence suggesting that the ongoing autoimmunity may trig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::e651ea5a98d581397bf13314e43c7b9b
Autor:
Grant J. Logan, Mario Mietzsch, Neeta Khandekar, Arlene D’Silva, Daniel Anderson, Mawj Mandwie, Jane Hsi, Austin R. Nelson, Paul Chipman, Jennifer Jackson, Peter Schofield, Daniel Christ, Christopher C. Goodnow, Joanne H. Reed, Michelle A. Farrar, Robert McKenna, Ian E. Alexander
Publikováno v:
Molecular Therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e2ebae53db06f725e5eceb4546372bc
https://doi.org/10.1016/j.ymthe.2023.03.032
https://doi.org/10.1016/j.ymthe.2023.03.032
Autor:
Amina Ahmad, Mawj Mandwie, Kim M. O'Sullivan, Christine Smyth, Jarrod York, Helen Doyle, Stephen R. Holdsworth, Matthew C. Pickering, Peter J. Lachmann, Ian E. Alexander, Grant J. Logan
Publikováno v:
Human Gene Therapy. 33:560-571
Adeno-associated virus (AAV) vectors are proving to be clinically transformative tools in the treatment of monogenic genetic disease. Rapid ongoing development of this technology promises to not only increase the number of monogenic disorders amenabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51dadd56aaeb42d64dc86dfc050ab4cd
https://doi.org/10.1089/hum.2021.264
https://doi.org/10.1089/hum.2021.264
Autor:
Que T. La, Binhai Ren, Grant J. Logan, Sharon C. Cunningham, Neeta Khandekar, Najah T. Nassif, Bronwyn A. O’Brien, Ian E. Alexander, Ann M. Simpson
Publikováno v:
Cells, Vol 9, Iss 10, p 2227 (2020)
Previously, we used a lentiviral vector to deliver furin-cleavable human insulin (INS-FUR) to the livers in several animal models of diabetes using intervallic infusion in full flow occlusion (FFO), with resultant reversal of diabetes, restoration of
Externí odkaz:
https://doaj.org/article/f8c03c105c804188a1339d6c7227bb54
Autor:
Albert J. R. Heck, Joanna R. Long, Terry R. Flotte, Maria Söderlund-Venermo, James M. Wilson, Jay Chiorini, Arun Srivastava, Dirk Grimm, Sawati Chatterjee, William W. Hauswirth, Guangping Gao, Robert Michael Kotin, Pat Ritschel, Ian E. Alexander, Joost Snijder, Amit C. Nathwani, Regine Heilbronn, Leszek Lisowski, Junghae Suh, Richard Snyder, Peter Tattersall, Dmitry Lyumkis, Juergen Dr Kleinschmidt, Michael Chapman, Colin R. Parrish, Aravind Asokan, José M. Almendral, Susan F. Cotmore, Grant J Logan, Kenneth Ira Berns
Publikováno v:
Human Gene Therapy. 32:321-326
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be6fcd52d390bb4fdec67ec23bb4ada
https://doi.org/10.1089/hum.2021.29158.mam
https://doi.org/10.1089/hum.2021.29158.mam
Autor:
Helen Doyle, Mawj Mandwie, Peter J. Lachmann, Talat H. Malik, Ian E. Alexander, Matthew C. Pickering, Amina Ahmad, Christine M. Smyth, Grant J Logan, Anna K. Dreismann
Publikováno v:
Human Gene Therapy.
The complement system is a key component of innate immunity, but impaired regulation influences disease susceptibility, including age-related macular degeneration and some kidney diseases. While complete complement inhibition has been used successful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77551bbc36e282ee491dfaf4ab15c440
https://doi.org/10.1089/hum.2021.022
https://doi.org/10.1089/hum.2021.022
Autor:
Ian E. Alexander, E Christina Hiemeyer, Mawj Mandwie, Linda B. Moran, Alyssa C. Gilmore, Talat H. Malik, Grant J Logan, Hannah J. Lomax-Browne, Kevin J. Marchbank, Allan Bradley, Amina Ahmad, Matthew C. Pickering, Katharina Boroviak, H. Terence Cook, Deborah P. Lavin, Daniel P. Gitterman
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The complement system is integral to innate immunity and host defense. However, inappropriate activation causes host tissue damage and disease. In health, this is prevented by a complex protein network that includes the factor H proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eabe5fe4d08e90610f39cce363a90ee
http://europepmc.org/articles/PMC8020653
http://europepmc.org/articles/PMC8020653
Autor:
Bronwyn A. O'Brien, Grant J Logan, Ann M. Simpson, Binhai Ren, Que T. La, Najah T. Nassif, Ian E. Alexander, Neeta Khandekar, Sharon C. Cunningham
Publikováno v:
Cells
Volume 9
Issue 10
Cells, Vol 9, Iss 2227, p 2227 (2020)
Volume 9
Issue 10
Cells, Vol 9, Iss 2227, p 2227 (2020)
Previously, we used a lentiviral vector to deliver furin-cleavable human insulin (INS-FUR) to the livers in several animal models of diabetes using intervallic infusion in full flow occlusion (FFO), with resultant reversal of diabetes, restoration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b789776a37fe8ea3fcc17f4eaa866eb