Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Grant J Carr"'
Autor:
Shanshan Liu, Guangyu Zhu, Leah Volk, Mary Koszelak-Rosenblum, Nian N. Huang, Rory Curtis, Fazlul Karim, Adrian R. Laciak, Grant J Carr, Mousheng Wu, Michael R. Lieber
Publikováno v:
The Journal of Biological Chemistry
The endonuclease Artemis is responsible for opening DNA hairpins during V(D)J recombination and for processing a subset of pathological DNA double-strand breaks. Artemis is an attractive target for the development of therapeutics to manage various B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7cbc3204e636454a1f20837a38e69a3
https://doi.org/10.1074/jbc.ra120.014136
https://doi.org/10.1074/jbc.ra120.014136
Publikováno v:
Journal of microbiological methods. 157
With increasing antibiotic resistance observed amongst clinical isolates of Neisseria gonorrhoeae , the second most prevalent sexually transmitted bacterial disease in the United States, there is still a need for antimicrobial susceptibility testing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e3d3a52cdfe8cb88038f4000e370fa
https://pubmed.ncbi.nlm.nih.gov/30629964
https://pubmed.ncbi.nlm.nih.gov/30629964
Autor:
Ricardo F. Reategui, Grant J Carr, Janet Adolphson, Ryan Newell, Joshua Rhea, Michele Luche, Ulla Mocek, John Rabenstein, Kathryn Waikins
Publikováno v:
Journal of Natural Products. 76:1523-1527
Three new compounds named leporizines A-C have been isolated from an Aspergillus sp. strain. Their structures were elucidated by analysis of 1D and 2D NMR spectra. Leporizines A and B were isolated during dereplication of hits from a high-throughput
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e12ba8382996e1ff67befd41d22124e
https://doi.org/10.1021/np300894y
https://doi.org/10.1021/np300894y
Autor:
Andrew Mearns Spragg, Jeffrey C. Webster, Iok Teng Kuok, Timothy Morley, Hai Nguyen, Svetlana Dobritsa, Grant J. Carr
Publikováno v:
SLAS Discovery. 18:75-84
Human interleukin 17 (IL-17) is a proinflammatory cytokine derived mainly from activated T cells. Extensive evidence points to a significant role of IL-17 in many autoimmune and infectious diseases, as well as tumorigenesis and transplant rejection,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec81d7985de811034592e614bac24a30
https://doi.org/10.1177/1087057112459350
https://doi.org/10.1177/1087057112459350
Autor:
Samuel A. Sakwa, Jiffry Ismail, Randall N. Davis, Bruce J. Sargent, Ronald N. Buckle, Sok Hui Choo, Christopher L. Cioffi, Liu Shuang, Visweswaran Parthasarathy, Kashinath Sadalapure, Andrew J. Mhyre, David T. J. Loong, Mei Bai, Yuri L. Khmelnitsky, Mark A. Wolf, Jun-Ho Maeng, Priya Gupta, Michele Luche, Xiao Fang, Grant J. Carr, Peter Guzzo, Wei Yee Leong, Mark Chung, Kalesh Karunakaran, Shailijia Panduga, Lakshman Matta, Nidhi Sachdev, Nicholas A. Moore, Sundaram Swaminathan, Edmund Carulli
We previously disclosed the discovery of rationally designed N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1 (GlyT-1), represented by analogues 10 and 11. We describe herein further structure-ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d9fabc408aa4db97d116ae32a0b60ba
http://hdl.handle.net/10044/1/41736
http://hdl.handle.net/10044/1/41736
Autor:
Douglas B. Kitchen, Svetlana Dobritsa, Mei Bai, Thomas D. Friedrich, Peter R. Guzzo, Grant J. Carr, Mark A. Wolf, Michael A. Lynch, Alexander Usyatinsky, Russell J. DeOrazio, Denise Peace, Kevin Fitzpatrick, Mohammed Sajad
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3017-3020
An indazole based series of glucocorticoid receptor agonists is reported. The SAR exploration of this scaffold yielded compounds with nanomolar affinity for the glucocorticoid receptor with indications of selectivity for the preferred transrepression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf658724c2cf779a78fc64c6106b32be
https://doi.org/10.1016/j.bmcl.2010.04.012
https://doi.org/10.1016/j.bmcl.2010.04.012
Autor:
Chris Smith, Macarena Irigoyen, Ulla Mocek, Joshua Rhea, John Rabenstein, Michele Luche, Khadidja Romari, D Craig Hopp, Linda Francis, Daniel Jacobsen, Grant J Carr, Midori Clarke
Publikováno v:
Journal of Natural Products. 72:276-279
Three new antibiotics, neopyrrolomycins B (1), C (2), and D (3), with potent activity against Gram-positive pathogens were discovered. They exhibited MIC values < 1 microg/mL versus a number of resistant strains. The compounds were obtained from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e6700ca3a74fd2a0e8a7eccd9a6567
https://doi.org/10.1021/np800632f
https://doi.org/10.1021/np800632f
Autor:
Michele Luche, D Craig Hopp, Midori Clarke, Joshua Rhea, Dennis J. Milanowski, Khadidja Romari, Linda Francis, Ulla Mocek, Macarena Irigoyen, Daniel Jacobsen, Grant J Carr, Chris Smith, John Rabenstein
Publikováno v:
Journal of Natural Products. 71:2032-2035
Two new xanthone antibiotics, citreamicin delta (1) and epsilon (2), with potent activity against Gram-positive pathogens including multidrug-resistant Staphylococcus aureus (MDRSA) were discovered. Compounds 1 and 2 exhibited MIC values < 1 microg/m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a10cc0189d6b78d1a186809c30c45d2
https://doi.org/10.1021/np800503z
https://doi.org/10.1021/np800503z
Autor:
D Craig Hopp, John Rabenstein, Linda Francis, Midori Clarke, Dennis J. Milanowski, Ulla Mocek, Michele Luche, Macarena Irigoyen, Khadidja Romari, Grant J Carr, Joshua Rhea, Chris Smith
Publikováno v:
The Journal of Antibiotics. 61:675-679
Resistance to currently available antibiotics has become a widely recognized crisis in the medical community. To address this, many companies and researchers are refocusing their attention towards natural products, which have an excellent track recor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89894abe236e1195da8fac919d882a19
https://doi.org/10.1038/ja.2008.95
https://doi.org/10.1038/ja.2008.95
Autor:
Joshua Rhea, Grant J Carr, Michele Luche, Linda Francis, Sasha Y. Lucas, John Rabenstein, Midori Clarke, Macarena Irigoyen, Ulla Mocek, D Craig Hopp, Chris Smith, Khadidja Romari
Publikováno v:
The Journal of Antibiotics. 65:623-625
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a1fe912d127f0b80940c57339fedde
https://doi.org/10.1038/ja.2012.78
https://doi.org/10.1038/ja.2012.78