Výsledky vyhledávání - "Grant G. Kelley"

SPFH2 Mediates the Endoplasmic Reticulum-associated Degradation of Inositol 1,4,5-Trisphosphate Receptors and Other Substrates in Mammalian Cells

Autor: Richard J.H. Wojcikiewicz, Yuan Wang, Grant G. Kelley, Margaret M.P. Pearce

Publikováno v: Journal of Biological Chemistry. 282:20104-20115

Inositol 1,4,5-trisphosphate (IP(3)) receptors are endoplasmic reticulum (ER) membrane calcium channels that, upon activation, become substrates for the ER-associated degradation (ERAD) pathway. Although it is clear that IP(3) receptors are polyubiqu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b77636d05a58221a0d84dd5a99daae51
https://doi.org/10.1074/jbc.m701862200

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Epac-mediated Activation of Phospholipase Cɛ Plays a Critical Role in β-Adrenergic Receptor-dependent Enhancement of Ca2+ Mobilization in Cardiac Myocytes

Autor: Alan V. Smrcka, Katherine A. Kaproth-Joslin, Huan Wang, Robert T. Dirksen, Emily A. Oestreich, Burns C. Blaxall, Sundeep Malik, Grant G. Kelley

Publikováno v: Journal of Biological Chemistry. 282:5488-5495

Recently we demonstrated that PLC(epsilon) plays an important role in beta-adrenergic receptor (betaAR) stimulation of Ca(2+)-induced Ca(2+) release (CICR) in cardiac myocytes. Here we have reported for the first time that a pathway downstream of bet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36efe3b134211d2560abe35719b195ab
https://doi.org/10.1074/jbc.m608495200

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Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible

Autor: Tom D. Bunney, Grant G. Kelley, Puneet Garg, Christian Becker, Alper Soylu, Dontscho Kerjaschki, Thomas Gudermann, Alexander Dietrich, Roxana Cleper, Jinhong Liu, Alexey N. Tsygin, Lina Basel-Vanagaite, Andreas Kispert, Caroline S. Sorli, Rannar Airik, Martin Pohl, Friedhelm Hildebrandt, Bettina E. Mucha, Matilda Katan, Martin Griebel, Alan V. Smrcka, Meera Goyal, Aysin Bakkaloglu, Katrin Hasselbacher, Bernward Hinkes, Rasheed Gbadegesin, John F. O'Toole, Rüdiger Waldherr, Massimo Attanasio, Roger C. Wiggins, Sudha Mudumana, Bryan L. Wharram, Christopher N. Vlangos, Edgar A. Otto, Asher D. Schachter, Lawrence B. Holzman, Fatih Ozaltin, Bethan E. Hoskins, Gudrun Nürnberg, Iain A. Drummond, Hassan Chaib, Dominik Seelow, Peter Nürnberg, Rakesh Verma, Shazia Ashraf, Dominik N. Müller, Hans Christian Hennies

Publikováno v: Nature Genetics. 38:1397-1405

Nephrotic syndrome, a malfunction of the kidney glomerular filter, leads to proteinuria, edema and, in steroid-resistant nephrotic syndrome, end-stage kidney disease. Using positional cloning, we identified mutations in the phospholipase C epsilon ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e48bc25306eb10553696ecbab090d6f
https://doi.org/10.1038/ng1918

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Phospholipase C ε Modulates β-Adrenergic Receptor– Dependent Cardiac Contraction and Inhibits Cardiac Hypertrophy

Autor: Grant G. Kelley, Robert T. Dirksen, Burns C. Blaxall, Karen L. Vikstrom, Naoya Maekawa, Emily A. Oestreich, Alan V. Smrcka, Tara A. Bullard, Huan Wang

Publikováno v: Circulation Research. 97:1305-1313

Phospholipase C (PLC) ε is a recently identified enzyme regulated by a wide range of molecules including Ras family small GTPases, Rho A, Gα 12/13 , and Gβγ with primary sites of expression in the heart and lung. In a screen for human signal tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43495e5f402af43933aa08ed8835e912
https://doi.org/10.1161/01.res.0000196578.15385.bb

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Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins

Autor: Grant G. Kelley, Sarah E. Reks, Alan V. Smrcka

Publikováno v: Biochemical Journal. 378:129-139

PLCepsilon (phospholipase Cepsilon) is a novel PLC that has a CDC25 guanine nucleotide exchange factor domain and two RA (Ras-association) domains of which the second (RA2) is critical for Ras activation of the enzyme. In the present studies, we exam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63282ad3c6d6717ad61160f9bd06db13
https://doi.org/10.1042/bj20031370

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Fuel and hormone regulation of phospholipase C β1 and δ1 overexpressed in RINm5F pancreatic beta cells

Autor: Grant G. Kelley, Sarah E. Reks, Joanne M. Ondrako

Publikováno v: Molecular and Cellular Endocrinology. 177:107-115

The mechanism by which glucose and other fuels stimulate phosphoinositide-specific phospholipase C (PLC) in pancreatic islet beta cells is not known. Previous studies have suggested that glucose may couple to PLC beta 1 and PLC delta 1. To determine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5003a02e0e1c6c2db8535bb85f840fc7
https://doi.org/10.1016/s0303-7207(01)00453-1

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Phospholipase Cepsilon: a novel Ras effector

Autor: Alan V. Smrcka, Sarah E. Reks, Joanne M. Ondrako, Grant G. Kelley

Publikováno v: The EMBO Journal. 20:743-754

Three classes of mammalian phosphoinositide-specific phospholipase C (PLC) have been characterized, PLCβ, PLCγ and PLCδ, that are differentially regulated by heterotrimeric G-proteins, tyrosine kinases and calcium. Here we describe a fourth class,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b042f61e6b70c487aac54cbca886c555
https://doi.org/10.1093/emboj/20.4.743

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