Design, Synthesis, and Characterization of the Macrocyclic Tetrapeptide cyclo[Pro-Sar-Phe-d-Phe]: A Mixed Opioid Receptor Agonist–Antagonist Following Oral Administration

Autor: Thomas F. Murray, Jeremy S. Coleman, Lisa L. Wilson, Jay P. McLaughlin, Shainnel O. Eans, Grant G. Simpson, Heather M. Stacy, Jane V. Aldrich, Ariana C. Brice-Tutt, Michael J. Ferracane

Publikováno v: ACS Chemical Neuroscience. 11:1324-1336

Substance abuse remains a serious public health crisis, affecting millions of people worldwide. Macrocyclic tetrapeptides like CJ-15,208 and [d-Trp]CJ-15,208 demonstrate opioid activity shown to attenuate the rewarding effects of cocaine in condition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac49a9dfa24622bcb3cff736f88e7fa9
https://doi.org/10.1021/acschemneuro.0c00086

Design, Synthesis, and Characterization of the Macrocyclic Tetrapeptide

Autor: Michael J, Ferracane, Ariana C, Brice-Tutt, Jeremy S, Coleman, Grant G, Simpson, Lisa L, Wilson, Shainnel O, Eans, Heather M, Stacy, Thomas F, Murray, Jay P, McLaughlin, Jane V, Aldrich

Publikováno v: ACS chemical neuroscience. 11(9)

Substance abuse remains a serious public health crisis, affecting millions of people worldwide. Macrocyclic tetrapeptides like CJ-15,208 and [d-Trp]CJ-15,208 demonstrate opioid activity shown to attenuate the rewarding effects of cocaine in condition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a6cc0a49dcb2bb5416ddcdcf5f68abc2
https://pubmed.ncbi.nlm.nih.gov/32251585

Scotland and the Low Countries 1124–1994

Autor: Grant G. Simpson

This collection of essays presents historical approaches to the links which have existed for over 800 years between Scotland and one of the areas of continental Europe closest to her: the Low Countries. Topics include: Flemish settlers in twelfth-cen

Incorporation of the HEART Score Into a Low-risk Chest Pain Pathway to Safely Decrease Admissions

Autor: Joseph A. Tyndall, Ideen Zeinali, Brandon Allen, Jared T. Freitas, Jeffrey J Chapa, Thomas Payton, Julie A Richter, Grant G. Simpson, Liam J Rawson

Publikováno v: Critical pathways in cardiology. 17(4)

Chest pain can be a challenging complaint to manage in the emergency department. A missed diagnosis can result in significant morbidity or mortality, whereas avoidable testing and hospitalizations can lead to increased health care costs, contribute t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429f9b0b98209a996ca2ca8e4c14d11e
https://pubmed.ncbi.nlm.nih.gov/30418248

A Patient-Centered Emergency Department Management Strategy for Sickle-Cell Disease Super-Utilizers

Autor: Joseph A. Tyndall, Lara G. Thompson, Brandon Allen, Jonathan J. Shuster, Donald M. Yealy, Grant G. Simpson, Deepa J. Borde, Alex A. Powel, Hallie R. Hahn, Linda A. Morris, Robert R. Leverence, Marc Zumberg

Publikováno v: Western Journal of Emergency Medicine
Simpson, Grant Gerald; Hahn, Hallie R.; Powell, Alex A.; Leverence, Robert R.; Morris, Linda A.; Thompson, Lara G.; et al.(2017). A Patient-Centered Emergency Department Management Strategy for Sickle-Cell Disease Super-Utilizers. Western Journal of Emergency Medicine, 18(3). doi: 10.5811/westjem.2016.11.32273. Retrieved from: http://www.escholarship.org/uc/item/7vq178h9

Introduction: A subpopulation of sickle-cell disease patients, termed super-utilizers, present frequently to emergency departments (EDs) for vaso-occlusive events and may consume disproportionate resources without broader health benefit. To address t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60caecb90d74dea236fafb01cd6f2959
https://pubmed.ncbi.nlm.nih.gov/28435481