Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Grant D. Barry"'
Autor:
Robert Reid, Ligong Liu, Rink-Jan Lohman, David A. Vesey, Grant D. Barry, Jeffrey Y. W. Mak, Mei-Kwan Yau, Jacky Y. Suen, Junxian Lim, Adam J. Cotterell, Yuhong Jiang, David P. Fairlie
Publikováno v:
ACS medicinal chemistry letters. 7(12)
PAR2 antagonists have potential for treating inflammatory, respiratory, gastrointestinal, neurological, and metabolic disorders, but few antagonists are known. Derivatives of GB88 (3) suggest that all four of its components bind at distinct PAR2 site
Autor:
Grant D. Barry, David P. Fairlie, Rink-Jan Lohman, Ligong Liu, David A. Vesey, Adam J. Cotterell, Jacky Y. Suen
Publikováno v:
The FASEB Journal. 26:2877-2887
Multiple serine proteases exert proinflammatory actions by signaling through protease-activated receptor-2 (PAR2) on the cell surface. Although inhibitors of individual proteases are anti-inflammatory, we sought to discover whether the first potent a
Autor:
Jacky Y. Suen, Grant D. Barry, Adam J. Cotterell, Robert Reid, Giang Thanh Le, David P. Fairlie
Publikováno v:
Journal of Medicinal Chemistry. 53:7428-7440
Human protease activated receptor 2 (PAR2) is a G protein-coupled receptor that is associated with inflammatory diseases and cancers. PAR2 is activated by serine proteases that cleave its N-terminus and by synthetic peptides corresponding to the new
Autor:
Grant D. Barry, Heng Boon Low, Bernadine M. Flanagan, Maria A. Halili, David P. Fairlie, Jacky Y. Suen, Bernhard Pfeiffer, Giang Thanh Le
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(20)
Protease activated receptor 2 (PAR(2)) is a G protein-coupled receptor implicated in inflammation and cancer. Only a few peptide agonists are known with greater potency than the native agonist SLIGRL-NH(2). Here we report 52 peptide agonists of PAR(2
Publikováno v:
Current medicinal chemistry. 13(3)
Protease activated receptors (PARs) are a category of G-protein coupled receptors (GPCRs) implicated in the progression of a wide range of diseases, including thrombosis, inflammatory disorders, and proliferative diseases. Signal transduction via PAR
Publikováno v:
Journal of Medicinal Chemistry; Oct2010, Vol. 53 Issue 20, p7428-7440, 13p