Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Grant D Nicol"'
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104529 (2014)
We examined whether nerve growth factor (NGF), an inflammatory mediator that contributes to chronic hypersensitivity, alters the intracellular signaling that mediates the sensitizing actions of PGE2 from activation of protein kinase A (PKA) to exchan
Externí odkaz:
https://doaj.org/article/5ba58510d4a94797a3a87966b7efaadb
Publikováno v:
Physiological Research. :S215-S225
Endothelin-1 (ET-1) and Nerve Growth Factor (NGF) are proteins, released from cancer-ridden tissues, which cause spontaneous pain and hypersensitivity to noxious stimuli. Here we examined the electrophysiological and behavioral effects of these two a
Publikováno v:
Neuroscience. 371:420-432
Nerve growth factor (NGF) plays a key role in the initiation as well as the prolonged heightened pain sensitivity of the inflammatory response. Previously, we showed that NGF rapidly augmented both the excitability of isolated rat sensory neurons and
Publikováno v:
Neuroscience. 340:384-397
The p75 neurotrophin receptor (p75NTR) and its activation of the sphingomyelin signaling cascade are essential for mechanical hypersensitivity resulting from locally injected nerve growth factor (NGF). Here the roles of the same effectors, and of the
Publikováno v:
Molecular and Cellular Neuroscience. 70:54-67
Guanine nucleotide exchange factors directly activated by cAMP (Epacs) have emerged as important signaling molecules mediating persistent hypersensitivity in animal models of inflammation, by augmenting the excitability of sensory neurons. Although E
Publikováno v:
Neuroscience. 254:312-323
Nerve growth factor (NGF) augments the excitability of isolated rat sensory neurons through activation of the p75 neurotrophin receptor (p75(NTR)) and its downstream sphingomyelin signaling cascade, wherein neutral sphingomyelinase(s) (nSMase), ceram
Publikováno v:
Neuroscience. 248:562-570
Nerve growth factor (NGF) is an important mediator in the initiation of the inflammatory response and NGF via activation of the p75 neurotrophin receptor (p75(NTR)) and downstream sphingomyelin signaling leads to significant enhancement of the excita
Publikováno v:
Trends in Pharmacological Sciences. 34:110-118
Approximately 20% of the population in Western countries suffers from chronic pain syndromes for which treatments are frequently insufficient or non-existent. In particular, chronic pain management with opiate/narcotic analgesics is often hampered by
Autor:
Grant D. Nicol, Xian Xuan Chi
Publikováno v:
Journal of Neurophysiology. 104:2741-2748
Sphingosine 1-phosphate (S1P) through its interaction with a family of G protein–coupled receptors (S1PR) is proving to have a significant impact on the activation of a variety of cell types, most notably those cells mediating the inflammatory resp
Autor:
Xian Xuan Chi, Grant D. Nicol
Publikováno v:
Journal of Neurophysiology. 98:2683-2692
Potassium channels play a critical role in regulating many aspects of action potential (AP) firing. To establish the contribution of the voltage-dependent potassium channel Kv1.1 in regulating excitability, we used the selective blocker dendrotoxin-K