Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Grant D Barish"'
Autor:
Krithika Ramachandran, Madhavi D Senagolage, Meredith A Sommars, Christopher R Futtner, Yasuhiro Omura, Amanda L Allred, Grant D Barish
Publikováno v:
PLoS Biology, Vol 17, Iss 10, p e3000467 (2019)
Skeletal muscles consist of fibers of differing metabolic activities and contractility, which become remodeled in response to chronic exercise, but the epigenomic basis for muscle identity and adaptation remains poorly understood. Here, we used chrom
Externí odkaz:
https://doaj.org/article/0ce485107a134309a73cef7079730099
Autor:
Meredith A Sommars, Krithika Ramachandran, Madhavi D Senagolage, Christopher R Futtner, Derrik M Germain, Amanda L Allred, Yasuhiro Omura, Ilya R Bederman, Grant D Barish
Publikováno v:
eLife, Vol 8 (2019)
Transcription is tightly regulated to maintain energy homeostasis during periods of feeding or fasting, but the molecular factors that control these alternating gene programs are incompletely understood. Here, we find that the B cell lymphoma 6 (BCL6
Externí odkaz:
https://doaj.org/article/31b0386732914031a75b86d14e851146
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86404 (2014)
Adiponectin (APN), an adipocytokine produced by adipose tissue, exerts pleiotropic actions regulating inflammation, metabolism and vascular homeostasis. APN levels are inversely correlated with obesity, type-2 diabetes, hypertension and cardiovascula
Externí odkaz:
https://doaj.org/article/8f49fcd4e3ab4e70a6ab38acce202197
Autor:
Daniel C. Levine, Hsin-Yu Kuo, Hee-Kyung Hong, Jonathan Cedernaes, Chelsea Hepler, Alexandra G. Wright, Meredith A. Sommars, Yumiko Kobayashi, Biliana Marcheva, Peng Gao, Olga R. Ilkayeva, Chiaki Omura, Kathryn M. Ramsey, Christopher B. Newgard, Grant D. Barish, Clara Bien Peek, Navdeep S. Chandel, Milan Mrksich, Joseph Bass
Publikováno v:
Nature Metabolism
In mammals, circadian rhythms are entrained to the light cycle and drive daily oscillations in levels of NAD+, a cosubstrate of the class III histone deacetylase sirtuin 1 (SIRT1) that associates with clock transcription factors. Although NAD+ also p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dce19cef36003030c6b9c71ba613826
http://europepmc.org/articles/PMC8688143
http://europepmc.org/articles/PMC8688143
Autor:
Yasuhiro Omura, Joshua A. Levine, Joshua Hay, Carlota Oleaga, Toshio Miyata, Nathalie Pamir, Grant D. Barish, Sanjiv J. Shah, Douglas E. Vaughan, Hagai Tavori, Sergio Fazio, Mesut Eren, Elizabeth Lux, Sadiya S. Khan, Ansel Philip Amaral, Meng Shang
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports
Plasminogen activator inhibitor 1 (PAI-1) is a functional biomarker of the metabolic syndrome. Previous studies have demonstrated that PAI-1 is a mechanistic contributor to several elements of the syndrome, including obesity, hypertension and insulin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c4e413468076d341f5da388738adab0
https://doaj.org/article/70f544abac804254b08f94ba760c8b5e
https://doaj.org/article/70f544abac804254b08f94ba760c8b5e
Autor:
Susan C. Hubchak, Angela Hyon, Richard M. Green, Alyssa Kriegermeier, Xiaoying Liu, Meredith A. Sommars, Brian LeCuyer, Grant D. Barish
Publikováno v:
Hepatology
BACKGROUND AND AIMS The unfolded protein response (UPR) is a coordinated cellular response to endoplasmic reticulum (ER) stress that functions to maintain cellular homeostasis. When ER stress is unresolved, the UPR can trigger apoptosis. Pathways wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8c564d40f983ac8e5e91ce5cc51fa98
https://europepmc.org/articles/PMC8886505/
https://europepmc.org/articles/PMC8886505/
Intermittent prednisone treatment in mice promotes exercise tolerance in obesity through adiponectin
Autor:
Mattia Quattrocelli, Michelle Wintzinger, Karen Miz, Manoj Panta, Ashok D. Prabakaran, Grant D. Barish, Navdeep S. Chandel, Elizabeth M. McNally
Publikováno v:
The Journal of experimental medicine. 219(5)
The fat–muscle communication regulates metabolism and involves circulating signals like adiponectin. Modulation of this cross-talk could benefit muscle bioenergetics and exercise tolerance in conditions like obesity. Chronic daily intake of exogeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::539713c87ab4fc7e214f2faafb4ec0a7
https://pubmed.ncbi.nlm.nih.gov/35363257
https://pubmed.ncbi.nlm.nih.gov/35363257
Autor:
Elizabeth M. McNally, Nancy L. Kuntz, Alexis R. Demonbreun, Mattia Quattrocelli, Zhen Jiang, Clara Bien Peek, Saptarsi M. Haldar, Aaron S. Zelikovich, Joseph Bass, Grant D. Barish
Publikováno v:
JCI Insight. 4
In humans, chronic glucocorticoid use is associated with side effects like muscle wasting, obesity, and metabolic syndrome. Intermittent steroid dosing has been proposed in Duchenne Muscular Dystrophy patients to mitigate the side effects seen with d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bdf97c620007d1f40c796576a111313
https://doi.org/10.1172/jci.insight.132402
https://doi.org/10.1172/jci.insight.132402
Autor:
Madhavi D. Senagolage, Grant D. Barish, Amanda L. Allred, Christopher R. Futtner, Krithika Ramachandran, Meredith A. Sommars, Yasuhiro Omura
Publikováno v:
PLoS Biology
PLoS Biology, Vol 17, Iss 10, p e3000467 (2019)
PLoS Biology, Vol 17, Iss 10, p e3000467 (2019)
Skeletal muscles consist of fibers of differing metabolic activities and contractility, which become remodeled in response to chronic exercise, but the epigenomic basis for muscle identity and adaptation remains poorly understood. Here, we used chrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00897942c2573de9d0bb0e63744c6b37
http://europepmc.org/articles/PMC6799888
http://europepmc.org/articles/PMC6799888
Autor:
Vaughan Douglas, Joshua A. Levine, Tianjiao Sun, Elizabeth Lux, Grant D. Barish, Mesut Eren, Toshiyo Miyata
Publikováno v:
Journal of the Endocrine Society
Plasminogen activator inhibitor 1 (PAI-1) is a member of the serpin family of proteases that inhibits tissue-type plasminogen activator and urokinase. Elevated levels of plasma PAI-1 are one of the hallmarks of obesity and are predictably elevated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b289e143e81b9d1328b14ad9a851e54a
http://europepmc.org/articles/PMC6554789
http://europepmc.org/articles/PMC6554789