Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Grant Andrew Mcnaughton-Smith"'
Autor:
Kerry Spear, Sripathy Venkatraman, Bingidimi I. Mobele, Cameron Gibb, Brian E. Marron, Grant Andrew Mcnaughton-Smith, Stephen M. Shaw, Mark J. Suto, Luckner Ulysse, Carl A. Lindmark
Publikováno v:
Organic Process Research & Development. 16:1385-1392
A scalable process for the manufacture of a potassium ion channel blocker was developed and optimized. Key features of the process include an optimized Grignard reaction, a direct cyanation of the intermediate trityl alcohol derivative, and an improv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa05b07efe10cd64afabcfffab98010f
https://doi.org/10.1021/op3000916
https://doi.org/10.1021/op3000916
Autor:
Alan D. Wickenden, Paul Christopher Fritch, William Harrison, C Wesley Eargle, James F Burns, George Salvatore Amato, Grant Andrew Mcnaughton-Smith, Leslie Jones, Rosemarie Roeloffs
Publikováno v:
Journal of Medicinal Chemistry. 53:887-896
Current drugs for the treatment of seizure disorders, although effective in many patients, still suffer from a number of failures and are not effective in some forms of resistant epilepsies. Historically, many of these drugs have multiple mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14bc9fb246d98b9cd04bf675d75fa04f
https://doi.org/10.1021/jm901497b
https://doi.org/10.1021/jm901497b
Autor:
James O. McNamara, Greg C. Rigdon, Grant Andrew Mcnaughton-Smith, Stephen Werness, Rosemarie Roeloffs, James Stables, Christopher Crean, Neil Ghodadra, Alan D. Wickenden
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 326:818-828
Openers or activators of neuronal KCNQ2/Q3 potassium channels decrease neuronal excitability and may provide benefit in the treatment of disorders of neuronal excitability such as epilepsy. In the present study, we evaluate the effects of ICA-27243 [
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd9a79df4148149c3a089dafe0ea650a
https://doi.org/10.1124/jpet.108.137794
https://doi.org/10.1124/jpet.108.137794
Publikováno v:
Expert Opinion on Therapeutic Patents. 14:457-469
Epilepsy and neuropathic pain are disorders characterised by excessive neuronal activity. These disorders are currently managed by drugs that are capable of dampening neuronal excitability, including voltage-gated sodium channel blockers, voltage-ope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9ae09f4d2ed2aaee47f353f396921e3
https://doi.org/10.1517/13543776.14.4.457
https://doi.org/10.1517/13543776.14.4.457
Autor:
George Salvatore Amato, Mark J. Suto, Brett Antonio, Theresa Mersch, Paul Christopher Fritch, Alan D. Wickenden, Grant Andrew Mcnaughton-Smith, Greg C. Rigdon, Rosemarie Roeloffs
Publikováno v:
ACS medicinal chemistry letters. 2(6)
A series of N-pyridyl benzamide KCNQ2/Q3 potassium channel openers were identified and found to be active in animal models of epilepsy and pain. The best compound 12 [ICA-027243, N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide] has an EC50 of 0.38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aecd7eba39cc0d236d7c10115372ec65
https://pubmed.ncbi.nlm.nih.gov/24900334
https://pubmed.ncbi.nlm.nih.gov/24900334
Autor:
Grant Andrew Mcnaughton-Smith, Carlo Brugnara, Roberto Corrocher, Lucia De Franceschi, Yves Beuzard, Jonathan W. Stocker
Publikováno v:
Blood. 101(6)
A prominent feature of sickle cell anemia is the presence of dehydrated red blood cells (RBCs) in circulation. Loss of potassium (K(+)), chloride (Cl(-)), and water from RBCs is thought to contribute to the production of these dehydrated cells. One m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c8db74de79a4b727bc4765a70c318b
https://pubmed.ncbi.nlm.nih.gov/12433690
https://pubmed.ncbi.nlm.nih.gov/12433690