Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Grant A Murphy"'
Autor:
David G Armstrong, Grant A Murphy, Rajinder P Singh-Moon, Amaan Mazhar, David J Cuccia, Vincent L Rowe
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 8, Iss 2 (2020)
Introduction The use of non-invasive vascular and perfusion diagnostics are an important part of assessing lower extremity ulceration and amputation risk in patients with diabetes mellitus. Methods for detecting impaired microvascular vasodilatory fu
Externí odkaz:
https://doaj.org/article/8efa2a7e7cdd4c0da636b790fe5daaf4
Autor:
Christopher K. Prier, Karla Camacho Soto, Jacob H. Forstater, Nadine Kuhl, Jeffrey T. Kuethe, Wai Ling Cheung-Lee, Michael J. Di Maso, Claire M. Eberle, Shane T. Grosser, Hsing-I Ho, Erik Hoyt, Anne Maguire, Kevin M. Maloney, Amanda Makarewicz, Jonathan P. McMullen, Jeffrey C. Moore, Grant S. Murphy, Karthik Narsimhan, Weilan Pan, Nelo R. Rivera, Anumita Saha-Shah, David A. Thaisrivongs, Deeptak Verma, Adeya Wyatt, Daniel Zewge
Publikováno v:
ACS Catalysis. :7707-7714
Enzymes are capable of unique and selective transformations that can enable sustainable chemical production. While many industrial processes have been developed using free enzymes in aqueous solutions, immobilizing enzymes on a solid support can offe
Autor:
David Prihoda, Danny A. Bitton, Rastislav Svarba, Jakub Arnold, Alejandro Vazquez-Otero, Jakub Kotowski, Grant S. Murphy, Ondrej Tupa, Josef Navratil, Ondrej Klempir, Russell Jay, Sebastian Wiewiora, Anna Gromek, Matej Marcisin, Kamila Clarova, Martin Spale, Lukas Holy, Kaori Hiraga, David Dzamba, Gergely Temesi, Nikita Vostrosablin, Marcin W Walas, Petr Mejzlik, Nicholas M. Marshall
Publikováno v:
ACS Synthetic Biology. 10:357-370
Protein engineering is the discipline of developing useful proteins for applications in research, therapeutic and industrial processes by modification of naturally occurring proteins or by invention of de novo proteins. Modern protein engineering rel
Autor:
Edward C. Sherer, Junyong Jo, Holst M. Halsey, Jack Liang, Niki R. Patel, Agustina Rodriguez-Granillo, Christopher C. Nawrat, Aaron M. Whittaker, Canada Keith A, Margie Borra-Garske, Nicholas M. Marshall, Kevin R. Campos, Anna Fryszkowska, Yingju Xu, Paul N. Devine, Shane T. Grosser, Grant S. Murphy, Jovana Nazor, Matthew D. Truppo, Benjamin F. Mann, Jeffrey C. Moore, Sandra A. Robaire, Gregory Hughes, Scott J. Novick, Da Duan, Jacob Forstater, Joshua N. Kolev, Deeptak Verma, Kevin M. Maloney, Oscar Alvizo, Mark A. Huffman, Li Xiao, Mark McLaughlin, Leo A. Joyce, Hao Yang
Publikováno v:
Science. 366:1255-1259
Maximal efficiency from enzyme cascades Enzymes are highly selective catalysts that can be useful for specific transformations in organic synthesis. Huffman et al. combined designer enzymes in a multistep cascade reaction (see the Perspective by O'Re
Autor:
Jessica A. Hurtak, Steven M. Silverman, Kevin M. Maloney, Patrick S. Fier, Jonathan Vroom, Neil A. Strotman, Mark A. Huffman, Hao Yang, Peter E. Maligres, Tamas Benkovics, Anders M. Knight, Grant S. Murphy, Weilan Pan, Artis Klapars, Jongrock Kong, William J. Morris, John A. McIntosh, Tetsuji Itoh, Hsing-I Ho, Anna Fryszkowska, Deeptak Verma
Publikováno v:
ACS Central Science
ACS Central Science, Vol 7, Iss 12, Pp 1980-1985 (2021)
ACS Central Science, Vol 7, Iss 12, Pp 1980-1985 (2021)
Molnupiravir (MK-4482) is an investigational antiviral agent that is under development for the treatment of COVID-19. Given the potential high demand and urgency for this compound, it was critical to develop a short and sustainable synthesis from sim
Autor:
John A. McIntosh, Zhijian Liu, Brian M. Andresen, Nastaran Salehi Marzijarani, Jeffrey C. Moore, Nicholas M. Marshall, Margie Borra-Garske, Jennifer V. Obligacion, Patrick S. Fier, Feng Peng, Jacob H. Forstater, Matthew S. Winston, Chihui An, Wonsuk Chang, Jongwon Lim, Mark A. Huffman, Steven P. Miller, Fuh-Rong Tsay, Michael D. Altman, Charles A. Lesburg, Dietrich Steinhuebel, B. Wesley Trotter, Jared N. Cumming, Alan Northrup, Xiaodong Bu, Benjamin F. Mann, Mirlinda Biba, Kaori Hiraga, Grant S. Murphy, Joshua N. Kolev, Amanda Makarewicz, Weilan Pan, Iman Farasat, Rachel S. Bade, Kevin Stone, Da Duan, Oscar Alvizo, Donovan Adpressa, Erik Guetschow, Erik Hoyt, Erik L. Regalado, Steve Castro, Nelo Rivera, Joseph P. Smith, Fengqiang Wang, Alejandro Crespo, Deeptak Verma, Stephanus Axnanda, Zachary E. X. Dance, Paul N. Devine, David Tschaen, Keith A. Canada, Paul G. Bulger, Benjamin D. Sherry, Matthew D. Truppo, Rebecca T. Ruck, Louis-Charles Campeau, David Jonathan Bennett, Guy R. Humphrey, Kevin R. Campos, Matthew L. Maddess
Publikováno v:
Nature. 603(7901)
The introduction of molecular complexity in an atom- and step-efficient manner remains an outstanding goal in modern synthetic chemistry. Artificial biosynthetic pathways are uniquely able to address this challenge by using enzymes to carry out multi
Autor:
Ketan M. Patel, Rajinder P. Singh-Moon, Vincent L. Rowe, Amaan Mazhar, David J. Cuccia, Grant A. Murphy, David G. Armstrong
Publikováno v:
Journal of Surgical Case Reports
The use of free flaps in lower extremity reconstructive surgery has seen growing adoption for treating tissue loss in patients with diabetes mellitus and peripheral artery disease as a means for limb preservation. The superficial circumflex iliac per
Autor:
Jonathan Vroom, Deeptak Verma, Pan W, William J. Morris, Tamas Benkovics, John A. McIntosh, Hao Yang, Tetsuji Itoh, Ho H, Knight A, Hurtak J, Neil A. Strotman, Grant S. Murphy, Peter E. Maligres, Kong J, Patrick S. Fier, Kevin M. Maloney, Steven M. Silverman, Mark A. Huffman
Molnupiravir (MK-4482) is an investigational direct-acting antiviral agent that is under development for the treatment of COVID-19. Given the potential high demand for this compound, it was critical to develop a sustainable and efficient synthesis fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8945d471b661a7a357883aca1a7bc9a6
https://doi.org/10.26434/chemrxiv.13472373.v1
https://doi.org/10.26434/chemrxiv.13472373.v1
Publikováno v:
Telemedicine, Telehealth and Telepresence ISBN: 9783030569167
Almost half of people with diabetes have peripheral nerve dysfunction (neuropathy; PN) or poor blood supply to the lower limb caused by diabetes or peripheral artery disease (PAD). They are at a high risk of developing foot complications, such as ulc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c9ad5df9e8eac5d854873fefd90e45a
https://doi.org/10.1007/978-3-030-56917-4_28
https://doi.org/10.1007/978-3-030-56917-4_28
Publikováno v:
Oxford Medical Case Reports
Closure of chronic lower extremity wounds is important for minimizing the risk of infection and amputation in a very high-risk population. Developments in tissue cultures and matrix therapies have shown promise in enhancing healing. The use of autolo