Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Grant A McNaughton-Smith"'
Autor:
Kerry Spear, Sripathy Venkatraman, Bingidimi I. Mobele, Cameron Gibb, Brian E. Marron, Grant Andrew Mcnaughton-Smith, Stephen M. Shaw, Mark J. Suto, Luckner Ulysse, Carl A. Lindmark
Publikováno v:
Organic Process Research & Development. 16:1385-1392
A scalable process for the manufacture of a potassium ion channel blocker was developed and optimized. Key features of the process include an optimized Grignard reaction, a direct cyanation of the intermediate trityl alcohol derivative, and an improv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa05b07efe10cd64afabcfffab98010f
https://doi.org/10.1021/op3000916
https://doi.org/10.1021/op3000916
Autor:
Alan D. Wickenden, Paul Christopher Fritch, William Harrison, C Wesley Eargle, James F Burns, George Salvatore Amato, Grant Andrew Mcnaughton-Smith, Leslie Jones, Rosemarie Roeloffs
Publikováno v:
Journal of Medicinal Chemistry. 53:887-896
Current drugs for the treatment of seizure disorders, although effective in many patients, still suffer from a number of failures and are not effective in some forms of resistant epilepsies. Historically, many of these drugs have multiple mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14bc9fb246d98b9cd04bf675d75fa04f
https://doi.org/10.1021/jm901497b
https://doi.org/10.1021/jm901497b
Autor:
James O. McNamara, Greg C. Rigdon, Grant Andrew Mcnaughton-Smith, Stephen Werness, Rosemarie Roeloffs, James Stables, Christopher Crean, Neil Ghodadra, Alan D. Wickenden
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 326:818-828
Openers or activators of neuronal KCNQ2/Q3 potassium channels decrease neuronal excitability and may provide benefit in the treatment of disorders of neuronal excitability such as epilepsy. In the present study, we evaluate the effects of ICA-27243 [
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd9a79df4148149c3a089dafe0ea650a
https://doi.org/10.1124/jpet.108.137794
https://doi.org/10.1124/jpet.108.137794
Publikováno v:
Expert Opinion on Therapeutic Patents. 14:457-469
Epilepsy and neuropathic pain are disorders characterised by excessive neuronal activity. These disorders are currently managed by drugs that are capable of dampening neuronal excitability, including voltage-gated sodium channel blockers, voltage-ope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9ae09f4d2ed2aaee47f353f396921e3
https://doi.org/10.1517/13543776.14.4.457
https://doi.org/10.1517/13543776.14.4.457
Publikováno v:
Tetrahedron. 52:2113-2124
Two routes have been explored for the preparation of the title 9 membered lactones. Lactonisation of a hydroxy acid bearing an embryonic unsaturated side chain followed by palladiumcatalysed chain extension was shown to be problematic. The preferred
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::306405f7865e57d0af6df4a202dcc427
https://doi.org/10.1016/0040-4020(95)01028-9
https://doi.org/10.1016/0040-4020(95)01028-9
Autor:
George Salvatore Amato, Mark J. Suto, Brett Antonio, Theresa Mersch, Paul Christopher Fritch, Alan D. Wickenden, Grant Andrew Mcnaughton-Smith, Greg C. Rigdon, Rosemarie Roeloffs
Publikováno v:
ACS medicinal chemistry letters. 2(6)
A series of N-pyridyl benzamide KCNQ2/Q3 potassium channel openers were identified and found to be active in animal models of epilepsy and pain. The best compound 12 [ICA-027243, N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide] has an EC50 of 0.38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aecd7eba39cc0d236d7c10115372ec65
https://pubmed.ncbi.nlm.nih.gov/24900334
https://pubmed.ncbi.nlm.nih.gov/24900334
Publikováno v:
ChemInform. 27
Two routes have been explored for the preparation of the title 9 membered lactones. Lactonisation of a hydroxy acid bearing an embryonic unsaturated side chain followed by palladiumcatalysed chain extension was shown to be problematic. The preferred
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54a5a4db65efdbd18cad75a7c27b7831
https://doi.org/10.1002/chin.199621183
https://doi.org/10.1002/chin.199621183
Autor:
Jonathan W. Stocker, Lucia De Franceschi, Grant A McNaughton-Smith, J Ford Burns, Gregory Cooksey Rigdon, Tara Shelton, Christopher Creech, Susan Arrington
Publikováno v:
Journal of medicinal chemistry. 51(4)
Sickle cell disease (SCD) is a hereditary condition characterized by deformation of red blood cells (RBCs). This phenomenon is due to the presence of abnormal hemoglobin that polymerizes upon deoxygenation. This effect is exacerbated when dehydrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52785fc3214275905e515ac31dd4eb03
https://pubmed.ncbi.nlm.nih.gov/18232633
https://pubmed.ncbi.nlm.nih.gov/18232633
Autor:
Grant Andrew Mcnaughton-Smith, Carlo Brugnara, Roberto Corrocher, Lucia De Franceschi, Yves Beuzard, Jonathan W. Stocker
Publikováno v:
Blood. 101(6)
A prominent feature of sickle cell anemia is the presence of dehydrated red blood cells (RBCs) in circulation. Loss of potassium (K(+)), chloride (Cl(-)), and water from RBCs is thought to contribute to the production of these dehydrated cells. One m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c8db74de79a4b727bc4765a70c318b
https://pubmed.ncbi.nlm.nih.gov/12433690
https://pubmed.ncbi.nlm.nih.gov/12433690
Publikováno v:
J. Chem. Soc., Chem. Commun.. :1593-1595
The title reaction has been used to prepare nine-membered lactones commencing from 2-vinyltetrahydrofurans and dichloroketene; the resulting Δ5-dichlorolactones are exclusively trans but dechlorination using Bu3SnH–AlBN (azoisobutyronitrile) achie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82d66d7a1b94571738624c4fa8aa408f
https://doi.org/10.1039/c39930001593
https://doi.org/10.1039/c39930001593