Výsledky vyhledávání - "Grant A L Bare"

Cross-Chiral, RNA-Catalyzed Exponential Amplification of RNA

Publikováno v: Journal of the American Chemical Society. 143:19160-19166

Informational macromolecules in biology are composed of subunits of a single handedness, d-nucleotides in nucleic acids and l-amino acids in proteins. Although this chiral uniformity may be expedient, it is not a chemical necessity, as demonstrated b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30aaee8b751c9e934bcd0a30a53990a6
https://doi.org/10.1021/jacs.1c09233

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Chemical Triphosphorylation of Oligonucleotides

Autor: Grant A L, Bare, David P, Horning

Publikováno v: Journal of Visualized Experiments.

The 5'-triphosphate is an essential nucleic acid modification found throughout all life and increasingly used as a functional modification of oligonucleotides in biotechnology and synthetic biology. Oligonucleotide 5'-triphosphates have historically

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0ad8557b90e3abab5db5ca5fe4a8fc
https://doi.org/10.3791/63877-v

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Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF 4 )‐Derived Connective Hubs for Bioconjugation to DNA and Proteins

Autor: Feng Liu, Hua Wang, Suhua Li, Grant A. L. Bare, Xuemin Chen, Chu Wang, John E. Moses, Peng Wu, K. Barry Sharpless

Publikováno v: Angewandte Chemie. 131:8113-8117

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a14de4c538ba15525194db63b098613
https://doi.org/10.1002/ange.201902489

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Synthesis of a Class of Fused δ-Sultone HeterocyclesviaDBU-Catalyzed Direct Annulative SuFEx Click of Ethenesulfonyl Fluorides and Pyrazolones or 1,3-Dicarbonyl Compounds

Autor: Hua-Li Qin, Shi-Meng Wang, Xing Chen, Gao-Feng Zha, Grant A. L. Bare, Jing Leng

Publikováno v: Advanced Synthesis & Catalysis. 359:3254-3260

(E)-2-(hetero)arylethenesulfonyl fluorides and (E,E)-1,3-dienylsulfonyl fluorides are bis-electrophiles and rare members of the sulfonyl fluoride family with limited information being known of their reactivity and synthetic utility. The direct annula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8394966217468f643a2071fe4bc5235
https://doi.org/10.1002/adsc.201700887

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Gram-Scale Synthesis of β-(Hetero)arylethenesulfonyl Fluorides via a Pd(OAc)2 Catalyzed Oxidative Heck Process with DDQ or AgNO3 as an Oxidant

Autor: Zhixiong Luo, Gao-Feng Zha, Zhen-Peng Shang, Jing Leng, Hua-Li Qin, Grant A. L. Bare

Publikováno v: Advanced Synthesis & Catalysis. 359:3237-3242

A practical oxidative Heck reaction between organoboronic acids and ethenesulfonyl fluoride (ESF) is developed. Aryl- and heteroaryl-boronic acids react efficiently and stereoselectively with ESF in the presence of a catalytic amount of Pd(OAc)2 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4516d3b18601a9039b99141f6b22d83
https://doi.org/10.1002/adsc.201700688

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A Heck-Matsuda Process for the Synthesis of β-Arylethenesulfonyl Fluorides: Selectively Addressable Bis-electrophiles for SuFEx Click Chemistry

Autor: Peng Wu, Grant A. L. Bare, Hua-Li Qin, Qinheng Zheng, K. Barry Sharpless

Publikováno v: Angewandte Chemie International Edition. 55:14155-14158

A Heck-Matsuda process for the synthesis of the otherwise difficult to access compounds, β-arylethenesulfonyl fluorides, is described. Ethenesulfonyl fluoride (i.e., vinylsulfonyl fluoride, or ESF) undergoes β-arylation with stable and readily prep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11bfb4146ce4a27037c2e54dba638c44
https://doi.org/10.1002/anie.201608807

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'Inverse Drug Discovery' Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates

Autor: Ian A. Wilson, Gabriel J. Brighty, K. Barry Sharpless, Stefano Forli, Hua Wang, Suhua Li, Wentao Chen, Jeffery W. Kelly, Benjamin F. Cravatt, Lars Plate, Evan T. Powers, David E. Mortenson, Grant A. L. Bare

Publikováno v: Journal of the American Chemical Society. 140(1)

Drug candidates are generally discovered using biochemical screens employing an isolated target protein or by utilizing cell-based phenotypic assays. Both noncovalent and covalent hits emerge from such endeavors. Herein, we exemplify an "Inverse Drug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda856191968c40956e8665044f9ce06
https://pubmed.ncbi.nlm.nih.gov/29265822

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Recent Developments on Phenstatins as Potent Antimitotic Agents

Autor: Grant A. L. Bare, Xing Chen, Syed Nasir Abbas Bukhari, Shi-Meng Wang, Gajjela Bharath Kumar, Hua-Li Qin, Jing Leng

Publikováno v: Current medicinal chemistry. 25(20)

Background: Phenstatin and their derivatives display remarkable antiproliferative activity toward a wide variety of preclinical tumor models. Structural simplicity and excellent stability of phenstatins offer a stimulating premise for developing vari

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https://pubmed.ncbi.nlm.nih.gov/29110592

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