Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Grant A, Howe"'
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185619 (2017)
The importance of microRNA (miRNA) to vascular biology is becoming increasingly evident; however, the function of a significant number of miRNA remains to be determined. In particular, the effect of growth factor regulation of miRNAs on endothelial c
Externí odkaz:
https://doaj.org/article/05c2d6f877214dfca72b4dd1c07deb7f
Autor:
Grant A Howe, Bin Xiao, Huijun Zhao, Khalid N Al-Zahrani, Mohamed S Hasim, James Villeneuve, Harmanjatinder S Sekhon, Glenwood D Goss, Luc A Sabourin, Jim Dimitroulakos, Christina L Addison
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150567 (2016)
Blockade of epidermal growth factor receptor (EGFR) activity has been a primary therapeutic target for non-small cell lung cancers (NSCLC). As patients with wild-type EGFR have demonstrated only modest benefit from EGFR tyrosine kinase inhibitors (TK
Externí odkaz:
https://doaj.org/article/21805c1dece148209f371f94cca74a0d
Autor:
Mark Clemons, Manijeh Daneshmand, Angel Arnaout, Huijun Zhao, Grant A. Howe, Susan J. Robertson, Christina L. Addison
Publikováno v:
Cancer Research. 76:P4-09
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer. Classic type ILC is generally regarded as indolent in nature with its favourable biologic characteristics such as low grade, ER positivity and luminal A subtype. Despit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::554ca6d2ed85f19462defa4b6504c85a
https://doi.org/10.1158/1538-7445.sabcs15-p4-09-08
https://doi.org/10.1158/1538-7445.sabcs15-p4-09-08
Autor:
Manijeh Daneshmand, Sophie Cousineau, Kathryn Ottolino-Perry, David P. Conrad, Fernando A. Angarita, Caroline J. Breitbach, Christina L. Addison, Carolina S. Ilkow, Fabrice Le Boeuf, Emma Burgess, Subash Sad, John C. Bell, Marie-Claude Bourgeois-Daigneault, Jean-Simon Diallo, Michael S. Huh, Harold L. Atkins, J. Andrea McCart, Jovian Tsang, Amelia Mottashed, Theresa Falls, Cory Batenchuk, David H. Kirn, Brian D. Lichty, Rozanne Arulanandam, Grant A. Howe, Naomi De Silva, Leda Raptis
Publikováno v:
Cancer Cell. 28:210-224
SummaryOncolytic viruses designed to attack malignant cells can in addition infect and destroy tumor vascular endothelial cells. We show here that this expanded tropism of oncolytic vaccinia virus to the endothelial compartment is a consequence of VE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74f0ed6dc0df4471f29fcad42b48063
https://doi.org/10.1016/j.ccell.2015.06.009
https://doi.org/10.1016/j.ccell.2015.06.009
Autor:
Prabhjot Sekhon, Roshan Sriram, Benjamin R. Pryce, Grant A. Howe, Kate Daniel, Luc A. Sabourin, Vivian Lo, Christina L. Addison, Khalid N. Al-Zahrani, Jennifer Quizi, Julien Yockell-Lelievre, Daniel R. Tessier, Kyla D. Baron, Marlene McKay, Andrée Gruslin
Publikováno v:
Developmental Dynamics. 243:640-651
Background: Over the past decade, the Ste20-like kinase SLK, has been implicated in several signaling processes. SLK repression has been shown to impair cell cycle kinetics and inhibit FAK-mediated cell migration. Here, using a gene trapped allele, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fab4d9db5a67029511d946536484b25
https://doi.org/10.1002/dvdy.24106
https://doi.org/10.1002/dvdy.24106
Autor:
Grant A. Howe, Christina L. Addison
Publikováno v:
Cell Adhesion & Migration. 6:71-77
Historically, a hallmark of tumorigenesis was the ability to grow in an anchorage-independent manner. Hence, tumors were thought to proliferate and survive independently of integrin attachment to the substratum. However, recent data suggest that inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e432ea3c23439894ee7e10805078eb3b
https://doi.org/10.4161/cam.20077
https://doi.org/10.4161/cam.20077
Publikováno v:
Molecular Cancer Research. 16:B35-B35
Cell survival and proliferation is tightly regulated by a number of interacting coordinated signaling proteins including the cyclin-dependent kinases (CDK). Palbociclib, a CDK4/6 inhibitor, has recently been shown to be very effective in the treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43f10896caeea75164d6352793fbb03d
https://doi.org/10.1158/1557-3125.advbc17-b35
https://doi.org/10.1158/1557-3125.advbc17-b35
Autor:
Khalid N, Al-Zahrani, Prabhjot, Sekhon, Daniel R, Tessier, Julien, Yockell-Lelievre, Benjamin R, Pryce, Kyla D, Baron, Grant A, Howe, Roshan K, Sriram, Kate, Daniel, Marlene, Mckay, Vivian, Lo, Jennifer, Quizi, Christina L, Addison, Andrée, Gruslin, Luc A, Sabourin
Publikováno v:
Developmental dynamics : an official publication of the American Association of Anatomists. 243(5)
Over the past decade, the Ste20-like kinase SLK, has been implicated in several signaling processes. SLK repression has been shown to impair cell cycle kinetics and inhibit FAK-mediated cell migration. Here, using a gene trapped allele, we have gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e27141dcd339e33b33496e89b3c18adf
https://pubmed.ncbi.nlm.nih.gov/24868594
https://pubmed.ncbi.nlm.nih.gov/24868594
Publikováno v:
Cancer Research. 74:1121-1121
Within North America, prostate cancer is the most commonly diagnosed cancer in men with devastating implications deriving from metastasis, particularly those established in the bone. We have elucidated mechanisms by which prostate cancer undergoes me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da23372f7b48541321fad277a6a4da01
https://doi.org/10.1158/1538-7445.am2014-1121
https://doi.org/10.1158/1538-7445.am2014-1121
Publikováno v:
Cancer Research. 74:753-753
The epidermal growth factor receptor (EGFR) is over-expressed in approximately 90% of non-small cell lung cancer (NSCLC) and as such, blockade of EGFR activity has been a primary therapeutic target for NSCLC. As patients with wild-type EGFR have demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6e14e082b8ac8ae8147d6173c4c6546
https://doi.org/10.1158/1538-7445.am2014-753
https://doi.org/10.1158/1538-7445.am2014-753