PVRIG is Expressed on Stem-Like T Cells in Dendritic Cell-Rich Niches in Tumors and Its Blockade May Induce Immune Infiltration in Non-Inflamed Tumors.

Autor: Alteber Z; Compugen Ltd., Holon, Israel., Cojocaru G; Compugen Ltd., Holon, Israel., Granit RZ; Compugen Ltd., Holon, Israel., Barbiro I; Compugen Ltd., Holon, Israel., Wool A; Compugen Ltd., Holon, Israel., Frenkel M; Compugen Ltd., Holon, Israel., Novik A; Compugen Ltd., Holon, Israel., Shuchami A; Compugen Ltd., Holon, Israel., Liang Y; Compugen Ltd., Holon, Israel., Carmi VD; Compugen Ltd., Holon, Israel., Sabath N; Compugen Ltd., Holon, Israel., Foreman R; Vizgen Inc., Cambridge, Massachusetts., Petrenko N; Vizgen Inc., Cambridge, Massachusetts., He J; Vizgen Inc., Cambridge, Massachusetts., Kliger Y; Compugen Ltd., Holon, Israel., Levy-Barda A; Biobank, Department of Pathology, Rabin Medical Center, Petah Tikva, Israel., Eitan R; The Sackler School of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel.; Gynecologic Oncology Division, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel., Raban O; The Sackler School of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel.; Gynecologic Oncology Division, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel., Sadot E; The Sackler School of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel.; Department of Surgery, Rabin Medical Center, Petach Tikva, Israel., Sulimani O; The Sackler School of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel.; Department of Surgery, Rabin Medical Center, Petach Tikva, Israel., Nathan AA; Department of Pathology, Rabin Medical Center, Petach Tikva, Israel., Adewoye H; Compugen USA, Inc., South San Francisco, California., Ferre P; Compugen Ltd., Holon, Israel., Levine Z; Compugen Ltd., Holon, Israel., Ophir E; Compugen Ltd., Holon, Israel.

Publikováno v: Cancer immunology research [Cancer Immunol Res] 2024 Jul 02; Vol. 12 (7), pp. 876-890.

A universal cell-free DNA approach for response prediction to preoperative chemoradiation in rectal cancer.

Autor: Grinshpun A; Sharett Institute of Oncology, Hadassah Medical Center, Jerusalem, Israel.; The Faculty of Medicine, The Hebrew University, Jerusalem, Israel., Kustanovich A; Sharett Institute of Oncology, Hadassah Medical Center, Jerusalem, Israel., Neiman D; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel., Lehmann-Werman R; The Faculty of Medicine, The Hebrew University, Jerusalem, Israel.; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel., Zick A; Sharett Institute of Oncology, Hadassah Medical Center, Jerusalem, Israel.; The Faculty of Medicine, The Hebrew University, Jerusalem, Israel., Meir K; The Faculty of Medicine, The Hebrew University, Jerusalem, Israel.; Department of Pathology, Hadassah Medical Center, Jerusalem, Israel., Vainer E; Department of Gastroenterology, Hadassah Medical Center, Jerusalem, Israel., Granit RZ; Sharett Institute of Oncology, Hadassah Medical Center, Jerusalem, Israel., Arad A; Sharett Institute of Oncology, Hadassah Medical Center, Jerusalem, Israel.; The Faculty of Medicine, The Hebrew University, Jerusalem, Israel., Daskal N; Sharett Institute of Oncology, Hadassah Medical Center, Jerusalem, Israel.; The Faculty of Medicine, The Hebrew University, Jerusalem, Israel., Schwartz R; Sharett Institute of Oncology, Hadassah Medical Center, Jerusalem, Israel., Sapir E; Radiotherapy Unit, Assuta Medical Center, Ashdod, Israel., Maoz M; Sharett Institute of Oncology, Hadassah Medical Center, Jerusalem, Israel., Tahover E; The Faculty of Medicine, The Hebrew University, Jerusalem, Israel.; Gastrointestinal Oncology Service, Department of Oncology, Sha'are Zedek Medical Center, Jerusalem, Israel., Moss J; Sharett Institute of Oncology, Hadassah Medical Center, Jerusalem, Israel.; The Faculty of Medicine, The Hebrew University, Jerusalem, Israel.; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel., Ben-Dov IZ; Department of Nephrology and Hypertension, Hadassah Medical Center, Jerusalem, Israel., Peretz T; Sharett Institute of Oncology, Hadassah Medical Center, Jerusalem, Israel.; The Faculty of Medicine, The Hebrew University, Jerusalem, Israel., Hubert A; Sharett Institute of Oncology, Hadassah Medical Center, Jerusalem, Israel.; The Faculty of Medicine, The Hebrew University, Jerusalem, Israel., Shemer R; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel., Dor Y; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.

Publikováno v: International journal of cancer [Int J Cancer] 2023 Apr 01; Vol. 152 (7), pp. 1444-1451. Date of Electronic Publication: 2022 Dec 14.

STAT3 activation in HER2-positive breast cancers: Analysis of data from a large prospective trial.

Autor: Sonnenblick A; Institute of Oncology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Agbor-Tarh D; Frontier Science (Scotland) Ltd, Kingussie, UK., de Azambuja E; Institut Jules Bordet, Université Libre de Bruxelles (U.L.B), Brussels, Belgium., Hultsch S; Breast International Group (BIG)-aisbl, Bruxelles, Belgium., Izquierdo M; Oncology Clinical Development, Oncology Business Unit, Novartis Pharma AG, Basel, Switzerland., Liu M; Mayo Clinic, Rochester, Minnesota, USA., Pruneri G; Department of Pathology, Fondazione IRCCS Istituto Nazionale Tumori, Milan and University of Milan, School of Medicine, Milan, Italy., Harbeck N; Brustzentrum der Universität München (LMU), München, Germany., Piccart M; Institut Jules Bordet, Université Libre de Bruxelles (U.L.B), Brussels, Belgium., Moreno-Aspita A; Division of Hematology/Oncology, Mayo Clinic, Jacksonville, Florida, USA., Granit RZ; Academix Bio Ltd, Jerusalem, Israel., Rouas G; Institut Jules Bordet, Université Libre de Bruxelles (U.L.B), Brussels, Belgium., Fahoum I; Pathology Department, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Sotiriou C; Institut Jules Bordet, Université Libre de Bruxelles (U.L.B), Brussels, Belgium.

Publikováno v: International journal of cancer [Int J Cancer] 2021 Mar 15; Vol. 148 (6), pp. 1529-1535. Date of Electronic Publication: 2020 Nov 23.

Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells' heterogeneity.

Autor: Schlesinger Y; The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, IMRIC, Faculty of Medicine, Hebrew University-Hadassah Medical School, Jerusalem, 91120, Israel., Yosefov-Levi O; The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, IMRIC, Faculty of Medicine, Hebrew University-Hadassah Medical School, Jerusalem, 91120, Israel., Kolodkin-Gal D; Department of Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, 91120, Israel.; Department of Developmental Biology and Cancer Research, IMRIC, Faculty of Medicine, Hebrew University-Hadassah Medical School, Jerusalem, 91120, Israel., Granit RZ; The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, IMRIC, Faculty of Medicine, Hebrew University-Hadassah Medical School, Jerusalem, 91120, Israel., Peters L; The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, IMRIC, Faculty of Medicine, Hebrew University-Hadassah Medical School, Jerusalem, 91120, Israel., Kalifa R; Department of Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, 91120, Israel.; Department of Developmental Biology and Cancer Research, IMRIC, Faculty of Medicine, Hebrew University-Hadassah Medical School, Jerusalem, 91120, Israel., Xia L; The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, IMRIC, Faculty of Medicine, Hebrew University-Hadassah Medical School, Jerusalem, 91120, Israel., Nasereddin A; Genomics Applications Laboratory, Core Research Facility, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel., Shiff I; Genomics Applications Laboratory, Core Research Facility, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel., Amran O; The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, IMRIC, Faculty of Medicine, Hebrew University-Hadassah Medical School, Jerusalem, 91120, Israel., Nevo Y; Info-CORE, Bioinformatics Unit of the I-CORE at the Hebrew University of Jerusalem and Hadassah Medical Center, Jerusalem, 91120, Israel., Elgavish S; Info-CORE, Bioinformatics Unit of the I-CORE at the Hebrew University of Jerusalem and Hadassah Medical Center, Jerusalem, 91120, Israel., Atlan K; Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem, 91120, Israel., Zamir G; Department of Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, 91120, Israel. RgideonZ@hadassah.org.il., Parnas O; The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, IMRIC, Faculty of Medicine, Hebrew University-Hadassah Medical School, Jerusalem, 91120, Israel. oren.parnas@gmail.com.

Publikováno v: Nature communications [Nat Commun] 2020 Sep 09; Vol. 11 (1), pp. 4516. Date of Electronic Publication: 2020 Sep 09.

Regulation of Cellular Heterogeneity and Rates of Symmetric and Asymmetric Divisions in Triple-Negative Breast Cancer.

Autor: Granit RZ; Department of Developmental Biology and Cancer Research, Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel., Masury H; Department of Developmental Biology and Cancer Research, Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel., Condiotti R; Department of Developmental Biology and Cancer Research, Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel., Fixler Y; Department of Developmental Biology and Cancer Research, Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel., Gabai Y; Department of Developmental Biology and Cancer Research, Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel., Glikman T; Department of Developmental Biology and Cancer Research, Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel., Dalin S; Department of Developmental Biology and Cancer Research, Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel., Winter E; Info-CORE, Bioinformatics Unit of the I-CORE Computation Center at The Hebrew University and Hadassah, Jerusalem 91120, Israel., Nevo Y; Info-CORE, Bioinformatics Unit of the I-CORE Computation Center at The Hebrew University and Hadassah, Jerusalem 91120, Israel., Carmon E; Department of Surgery, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel., Sella T; Department of Radiology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel., Sonnenblick A; Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel., Peretz T; Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel., Lehmann U; Institute of Pathology, Medizinische Hochschule Hannover, 30625 Hannover, Germany., Paz K; Champions Oncology, Inc., Baltimore, MD 21205, USA., Piccioni F; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Regev A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Howard Hughes Medical Institute and David H. Koch Institute of Integrative Cancer Biology, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Root DE; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Ben-Porath I; Department of Developmental Biology and Cancer Research, Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel. Electronic address: ittaibp@mail.huji.ac.il.

Publikováno v: Cell reports [Cell Rep] 2018 Sep 18; Vol. 24 (12), pp. 3237-3250.