Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation

Autor: Gastaldi, Simone, Rocca, Carmine, Gianquinto, Eleonora, Granieri, Maria Concetta, Boscaro, Valentina, Blua, Federica, Rolando, Barbara, Marini, Elisabetta, Gallicchio, Margherita, De Bartolo, Anna, Romeo, Naomi, Mazza, Rosa, Fedele, Francesco, Pagliaro, Pasquale, Penna, Claudia, Spyrakis, Francesca, Bertinaria, Massimo, Angelone, Tommaso

Inspired by the recent advancements in understanding the binding mode of sulfonylurea-based NLRP3 inhibitors to the NLRP3 sensor protein, we developed new NLRP3 inhibitors by replacing the central sulfonylurea moiety with different heterocycles. Comp

Externí odkaz: http://arxiv.org/abs/2309.07939

The redox-active defensive Selenoprotein T as a novel stress sensor protein playing a key role in the pathophysiology of heart failure

Autor: Anna De Bartolo, Teresa Pasqua, Naomi Romeo, Vittoria Rago, Ida Perrotta, Francesca Giordano, Maria Concetta Granieri, Alessandro Marrone, Rosa Mazza, Maria Carmela Cerra, Benjamin Lefranc, Jérôme Leprince, Youssef Anouar, Tommaso Angelone, Carmine Rocca

Publikováno v: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-21 (2024)

Abstract Maladaptive cardiac hypertrophy contributes to the development of heart failure (HF). The oxidoreductase Selenoprotein T (SELENOT) emerged as a key regulator during rat cardiogenesis and acute cardiac protection. However, its action in chron

Externí odkaz: https://doaj.org/article/897b28636dbf40f0a12e6a868b0d04ba

Sull’Infinito di Giordano Bruno (On the Infinite by Giordano Bruno)

Autor: Luca Granieri

Publikováno v: Science & Philosophy, Vol 12, Iss 1 (2024)

Abstract The notion of infinity and its atomistic counterpart are discussed in the framework of Giordano Bruno philosophy. The role played by mathematics is considered as well. Keywords: mathematics; atomism; philosophy of science; history of scienc

Externí odkaz: https://doaj.org/article/10b4b37654f04ad59fa31c3665bb2050

ECLAPTE: Effective Closure of LAParoTomy in Emergency—2023 World Society of Emergency Surgery guidelines for the closure of laparotomy in emergency settings

Autor: Simone Frassini, Lorenzo Cobianchi, Paola Fugazzola, Walter L. Biffl, Federico Coccolini, Dimitrios Damaskos, Ernest E. Moore, Yoram Kluger, Marco Ceresoli, Raul Coimbra, Justin Davies, Andrew Kirkpatrick, Isidoro Di Carlo, Timothy C. Hardcastle, Arda Isik, Massimo Chiarugi, Kurinchi Gurusamy, Ronald V. Maier, Helmut A. Segovia Lohse, Hans Jeekel, Marja A. Boermeester, Fikri Abu-Zidan, Kenji Inaba, Dieter G. Weber, Goran Augustin, Luigi Bonavina, George Velmahos, Massimo Sartelli, Salomone Di Saverio, Richard P. G. Ten Broek, Stefano Granieri, Francesca Dal Mas, Camilla Nikita Farè, Jacopo Peverada, Simone Zanghì, Jacopo Viganò, Matteo Tomasoni, Tommaso Dominioni, Enrico Cicuttin, Andreas Hecker, Giovanni D. Tebala, Joseph M. Galante, Imtiaz Wani, Vladimir Khokha, Michael Sugrue, Thomas M. Scalea, Edward Tan, Mark A. Malangoni, Nikolaos Pararas, Mauro Podda, Belinda De Simone, Rao Ivatury, Yunfeng Cui, Jeffry Kashuk, Andrew Peitzman, Fernando Kim, Emmanouil Pikoulis, Gabriele Sganga, Osvaldo Chiara, Michael D. Kelly, Ingo Marzi, Edoardo Picetti, Vanni Agnoletti, Nicola De’Angelis, Giampiero Campanelli, Marc de Moya, Andrey Litvin, Aleix Martínez-Pérez, Ibrahima Sall, Sandro Rizoli, Gia Tomadze, Boris Sakakushev, Philip F. Stahel, Ian Civil, Vishal Shelat, David Costa, Alain Chichom-Mefire, Rifat Latifi, Mircea Chirica, Francesco Amico, Amyn Pardhan, Vidya Seenarain, Nikitha Boyapati, Basil Hatz, Travis Ackermann, Sandun Abeyasundara, Linda Fenton, Frank Plani, Rohit Sarvepalli, Omid Rouhbakhshfar, Pamela Caleo, Victor Ho-Ching Yau, Kristenne Clement, Erasmia Christou, Ana María González Castillo, Preet K. S. Gosal, Sunder Balasubramaniam, Jeremy Hsu, Kamon Banphawatanarak, Michele Pisano, Toro Adriana, Altomare Michele, Stefano P. B. Cioffi, Andrea Spota, Fausto Catena, Luca Ansaloni

Publikováno v: World Journal of Emergency Surgery, Vol 18, Iss 1, Pp 1-22 (2023)

Abstract Laparotomy incisions provide easy and rapid access to the peritoneal cavity in case of emergency surgery. Incisional hernia (IH) is a late manifestation of the failure of abdominal wall closure and represents frequent complication of any abd

Externí odkaz: https://doaj.org/article/79e167067dc8429193ea18bfd84aa85d

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