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Akademický článek

An improved reporter identifies ruxolitinib as a potent and cardioprotective CaMKII inhibitor.

Autor: Reyes Gaido OE; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Pavlaki N; Department of Cardiology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA., Granger JM; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Mesubi OO; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Liu B; Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA., Lin BL; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Long A; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Walker D; Department of Cardiology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA., Mayourian J; Department of Cardiology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA., Schole KL; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Terrillion CE; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Nkashama LJ; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Hulsurkar MM; Cardiovascular Research Institute and Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Dorn LE; Cardiovascular Research Institute and Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Ferrero KM; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Huganir RL; Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA., Müller FU; Institute of Pharmacology and Toxicology, University of Münster, Münster 48149, Germany., Wehrens XHT; Cardiovascular Research Institute and Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.; Departments of Medicine, Neuroscience, and Pediatrics, Center for Space Medicine, Baylor College of Medicine, Houston, TX 77030, USA., Liu JO; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Luczak ED; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Bezzerides VJ; Department of Cardiology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA., Anderson ME; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Division of Biological Sciences and the Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2023 Jun 21; Vol. 15 (701), pp. eabq7839. Date of Electronic Publication: 2023 Jun 21.

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Akademický článek

CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution.

Autor: Wang Q; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA. qinchuan.wang@jhmi.edu., Hernández-Ochoa EO; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA., Viswanathan MC; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA., Blum ID; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA., Do DC; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA., Granger JM; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA., Murphy KR; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA., Wei AC; Department of Electrical Engineering, Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan., Aja S; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Center for Metabolism and Obesity Research, Johns Hopkins School of Medicine, Baltimore, MD, USA., Liu N; Center for Genetic Muscle Disorders, Kennedy Krieger Institute, Baltimore, MD, USA., Antonescu CM; Johns Hopkins Computational Biology Consulting Core, Baltimore, MD, USA., Florea LD; Johns Hopkins Computational Biology Consulting Core, Baltimore, MD, USA., Talbot CC Jr; Institute for Basic Biomedical Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA., Mohr D; Johns Hopkins School of Medicine Genetic Resources Core Facility, Baltimore, MD, USA., Wagner KR; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Center for Genetic Muscle Disorders, Kennedy Krieger Institute, Baltimore, MD, USA., Regot S; Department of Molecular Biology & Genetics, Johns Hopkins School of Medicine, Baltimore, MD, USA., Lovering RM; Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA., Gao P; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA., Bianchet MA; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University, Baltimore, MD, USA., Wu MN; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA., Cammarato A; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA., Schneider MF; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA., Bever GS; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Center for Functional Anatomy & Evolution, Johns Hopkins School of Medicine, Baltimore, MD, USA., Anderson ME; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA. mark.anderson@jhmi.edu.

Publikováno v: Nature communications [Nat Commun] 2021 May 26; Vol. 12 (1), pp. 3175. Date of Electronic Publication: 2021 May 26.

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