Výsledky vyhledávání - "Granger G.C. Hwa"

Akademický článek

Kinetics and MR-Based Monitoring of AAV9 Vector Delivery into Cerebrospinal Fluid of Nonhuman Primates

Autor: Kousaku Ohno, Lluis Samaranch, Piotr Hadaczek, John R. Bringas, Philip C. Allen, Vivek Sudhakar, Diane E. Stockinger, Christopher Snieckus, Michael V. Campagna, Waldy San Sebastian, Jerusha Naidoo, Haifeng Chen, John Forsayeth, Ernesto A. Salegio, Granger G.C. Hwa, Krystof S. Bankiewicz

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 13, Iss , Pp 47-54 (2019)

Here we evaluated the utility of MRI to monitor intrathecal infusions in nonhuman primates. Adeno-associated virus (AAV) spiked with gadoteridol, a gadolinium-based MRI contrast agent, enabled real-time visualization of infusions delivered either via

Externí odkaz: https://doaj.org/article/5a819b72674d4e9490c437bdab03d8bd

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Optimization of capsaicin‐induced dermal blood flow measurement by laser Doppler imaging in cynomolgus macaque

Autor: Jeremy M. Yeung, Jeffrey B. Lo, Sheung Pun Tsai, Granger G.C. Hwa, Jeffrey A. Roberts, Phillip C. Allen

Publikováno v: Journal of Medical Primatology. 50:291-298

BACKGROUND Capsaicin is used in several areas of non-human primate research including allodynia and dermal blood flow (DBF). The capsaicin-induced DBF increase was measured using laser Doppler imaging (LDI), but this response is known to diminish upo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1adb03c12a1cda0af7864e8907c34c6
https://doi.org/10.1111/jmp.12544

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Feasibility of Targeted Delivery of AAV5-GFP into the Cerebellum of Nonhuman Primates Following a Single Convection-Enhanced Delivery Infusion

Autor: Marc Gonzalez, Granger G.C. Hwa, Diane E. Stockinger, Summer Copeland, Emily Lambert, Mira J. Cukrov, Abigail Green, Jeremy M. Yeung, Rachel Lortz, Ernesto A. Salegio

Publikováno v: Human gene therapy. 33(1-2)

In this study, we built upon our previous work to demonstrate the distribution and transport of AAV5-GFP following a single CED infusion into the nonhuman primate cerebellum, with no untoward side effects noted. Dosing under MRI guidance revealed a 6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d69b788ee0f30f2b2abba78b422105
https://pubmed.ncbi.nlm.nih.gov/34779239

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Kinetics and MR-Based Monitoring of AAV9 Vector Delivery into Cerebrospinal Fluid of Nonhuman Primates

Autor: Lluis Samaranch, John Forsayeth, Waldy San Sebastian, Krystof S. Bankiewicz, Ernesto A. Salegio, Philip C. Allen, Piotr Hadaczek, Haifeng Chen, Michael V. Campagna, Jerusha Naidoo, Granger G.C. Hwa, Kousaku Ohno, John Bringas, Vivek Sudhakar, Diane E. Stockinger, Christopher Snieckus

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 13, Iss, Pp 47-54 (2019)
Molecular Therapy. Methods & Clinical Development

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e868c604fb9c50fcf1cdebefedd028e
http://www.sciencedirect.com/science/article/pii/S2329050118301232

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Effects of transdermal mirtazapine on hyporexic rhesus and cynomolgus macaques (Macaca mulatta and Macaca fascicularis)

Autor: Granger G.C. Hwa, Diane E. Stockinger, Jeffrey A. Roberts, Kriscelle A. Mendoza, Mira J. Cukrov

Publikováno v: Journal of medical primatologyREFERENCES. 50(2)

Background Hyporexia and weight loss are important indicators of physical and psychological well-being in macaque colonies. An FDA-approved transdermal formulated Mirtazapine (MTZ) shows effectiveness in managing feline hyporexia. This study sought t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a3f899f3e96d1172d37fe39d8e3611f
https://pubmed.ncbi.nlm.nih.gov/33528049

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Plasma and CSF oxytocin levels after intranasal and intravenous oxytocin in awake macaques

Autor: Diane E. Stockinger, Granger G.C. Hwa, Philip C. Allen, Sridhar Samineni, Sara M. Freeman, Jeffrey A. Roberts, Karen L. Bales

Publikováno v: Freeman, SM; Samineni, S; Allen, PC; Stockinger, D; Bales, KL; Hwa, GGC; et al.(2016). Plasma and CSF oxytocin levels after intranasal and intravenous oxytocin in awake macaques. Psychoneuroendocrinology, 66, 185-194. doi: 10.1016/j.psyneuen.2016.01.014. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/3r165814

© 2016 Elsevier Ltd. Oxytocin (OT) is a neuropeptide that mediates a variety of complex social behaviors in animals and humans. Intranasal OT has been used as an experimental therapeutic for human conditions characterized by deficits in social funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60386c7eceabc201d3af342e081f1553
https://doi.org/10.1016/j.psyneuen.2016.01.014

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Targeted Delivery and Tolerability of MRI-Guided CED Infusion into the Cerebellum of Nonhuman Primates

Autor: Ernesto A. Salegio, Michael V. Campagna, Granger G.C. Hwa, Diane E. Stockinger, Philip C. Allen, Yuanquan Song

Publikováno v: Human gene therapy methods. 29(4)

This study explored the feasibility of intraparenchymal delivery (gadoteridol and/or Serotype 5 Adeno-Associated Viral Vector-enhanced Green Fluorescent Protein [AAV5-eGFP]) into the cerebellum of nonhuman primates using real-time magnetic resonance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3849b9bf1feb67067c8517a7be17aa87
https://pubmed.ncbi.nlm.nih.gov/29953257

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Membrane properties of rat subicular neurons in vitro

Autor: Granger G.C. Hwa, Massimo Avoli, Donatella Mattia

Publikováno v: Scopus-Elsevier

1. Conventional intracellular recordings were performed in rat hippocampal slices to investigate the electrophysiological properties of subicular neurons. These cells had a resting membrane potential (RMP) of -66 +/- 7.2 mV (mean +/- SD; n = 50), inp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96bfe1607c03cac1eba9183d21e1f7e1
https://doi.org/10.1152/jn.1993.70.3.1244

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Excitatory synaptic transmission mediated by NMDA and non-NMDA receptors in the superficial/middle layers of the epileptogenic human neocortex maintained in vitro

Autor: Granger G.C. Hwa, Massimo Avoli

Publikováno v: Neuroscience Letters. 143:83-86

Conventional intracellular recordings were made from regular-spiking cells located in layers II-IV to examine the involvement of excitatory amino acid receptors in synaptic transmission in epileptogenic human neocortical slices maintained in vitro. E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b705bdef0012f8b6597d31e2f9a3ed41
https://doi.org/10.1016/0304-3940(92)90238-3

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Cesium Potentiates Epileptiform Activities Induced by Bicuculline Methiodide in Rat Neocortex Maintained In Vitro

Autor: Granger G.C. Hwa, Massimo Avoli

Publikováno v: Epilepsia. 32:747-754

Summary: We report that extracellular application of cesium (Cs +, 3 mM) potentiated the epileptiform discharge evoked by GABAA-receptor antagonist bicuculline methiodide (BMI 50 μ.M) in rat neocortical slices maintained in vitro. Cs+ changed BMI-in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e250b5848bc966bed70117ad62d1f6e4
https://doi.org/10.1111/j.1528-1157.1991.tb05529.x

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