Zobrazeno 1 - 10
of 468
pro vyhledávání: '"Grandis, JR"'
Autor:
Peyser ND, Grandis JR
Publikováno v:
OncoTargets and Therapy, Vol 2013, Iss default, Pp 999-1010 (2013)
Noah D Peyser, Jennifer R Grandis Departments of Otolaryngology and Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Abstract: The signal transducer and activator of transcription (STAT) family of pr
Externí odkaz:
https://doaj.org/article/341b510b68ee4c49bb64700b80b4b1de
Autor:
Geiger, JL, Bauman, JE, Gibson, MK, Gooding, WE, Varadarajan, P, Kotsakis, A, Martin, D, Gutkind, JS, Hedberg, ML, Grandis, JR, Argiris, A
Publikováno v:
Head & neck, vol 38, iss 12
Geiger, JL; Bauman, JE; Gibson, MK; Gooding, WE; Varadarajan, P; Kotsakis, A; et al.(2016). Phase II trial of everolimus in patients with previously treated recurrent or metastatic head and neck squamous cell carcinoma. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 38(12), 1759-1764. doi: 10.1002/hed.24501. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/3kk8797t
Geiger, JL; Bauman, JE; Gibson, MK; Gooding, WE; Varadarajan, P; Kotsakis, A; et al.(2016). Phase II trial of everolimus in patients with previously treated recurrent or metastatic head and neck squamous cell carcinoma. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 38(12), 1759-1764. doi: 10.1002/hed.24501. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/3kk8797t
BackgroundPatients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) demonstrate aberrant activation of the phosphotidylinositol-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway. We examined the efficacy of evero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::066832df5ae1a9f8afd877ffb41c435b
https://escholarship.org/uc/item/3kk8797t
https://escholarship.org/uc/item/3kk8797t
Autor:
Khan, Z, Epstein, JB, Marur, S, Gillespie, MB, Feldman, L, Tsai, H-L, Zhang, Z, Wang, H, Sciubba, J, Ferris, RL, Grandis, JR, Gibson, M, Koch, W, Tufano, R, Westra, W, Tsottles, N, Ozawa, H, Chung, CH, Califano, JA
Publikováno v:
Khan, Z; Epstein, JB; Marur, S; Gillespie, MB; Feldman, L; Tsai, H-L; et al.(2016). Cetuximab activity in dysplastic lesions of the upper aerodigestive tract (vol 53, pg 60, 2016). ORAL ONCOLOGY, 57, E8-E8. doi: 10.1016/j.oraloncology.2016.03.018. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/2gj2t7bs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::b8e93a136e06bb23dbc9c2ab7c54becf
http://www.escholarship.org/uc/item/2gj2t7bs
http://www.escholarship.org/uc/item/2gj2t7bs
Autor:
Hedberg, ML, Goh, G, Chiosea, SI, Bauman, JE, Freilino, ML, Zeng, Y, Wang, L, Diergaarde, BB, Gooding, WE, Lui, VWY, Herbst, RS, Lifton, RP, Grandis, JR
Publikováno v:
Hedberg, ML; Goh, G; Chiosea, SI; Bauman, JE; Freilino, ML; Zeng, Y; et al.(2016). Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma (vol 126, pg 169, 2016). JOURNAL OF CLINICAL INVESTIGATION, 126(4), 1606-1606. doi: 10.1172/JCI86862. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/9tq84148
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::e6ccb375a132a6adc744096021d460f7
http://www.escholarship.org/uc/item/9tq84148
http://www.escholarship.org/uc/item/9tq84148
Autor:
Dixit, R, Weissfeld, JL, Wilson, DO, Balogh, P, Sufka, P, Siegfried, JM, Grandis, JR, Diergaarde, B
Publikováno v:
Cancer, vol 121, iss 9
Dixit, R; Weissfeld, JL; Wilson, DO; Balogh, P; Sufka, P; Siegfried, JM; et al.(2015). Incidence of head and neck squamous cell carcinoma among subjects at high risk of lung cancer: Results from the Pittsburgh Lung Screening Study. Cancer. doi: 10.1002/cncr.29189. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/3tv3z1h5
Dixit, R; Weissfeld, JL; Wilson, DO; Balogh, P; Sufka, P; Siegfried, JM; et al.(2015). Incidence of head and neck squamous cell carcinoma among subjects at high risk of lung cancer: Results from the Pittsburgh Lung Screening Study. Cancer, 121(9), 1431-1435. doi: 10.1002/cncr.29189. UCSF: Retrieved from: http://www.escholarship.org/uc/item/6vd9g2s7
Dixit, R; Weissfeld, JL; Wilson, DO; Balogh, P; Sufka, P; Siegfried, JM; et al.(2015). Incidence of head and neck squamous cell carcinoma among subjects at high risk of lung cancer: Results from the Pittsburgh Lung Screening Study. Cancer. doi: 10.1002/cncr.29189. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/3tv3z1h5
Dixit, R; Weissfeld, JL; Wilson, DO; Balogh, P; Sufka, P; Siegfried, JM; et al.(2015). Incidence of head and neck squamous cell carcinoma among subjects at high risk of lung cancer: Results from the Pittsburgh Lung Screening Study. Cancer, 121(9), 1431-1435. doi: 10.1002/cncr.29189. UCSF: Retrieved from: http://www.escholarship.org/uc/item/6vd9g2s7
© 2015 American Cancer Society. Earlier diagnosis of head and neck cancer should lead to improved outcomes. However, because head and neck cancer is relatively rare, screening of the general population is impractical. Results from the current study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7ce0b2697097b4f41f422813ee712c8f
https://escholarship.org/uc/item/3tv3z1h5
https://escholarship.org/uc/item/3tv3z1h5
Autor:
Grandis, Jennifer, Gough, AH, Chen, N, Shun, TY, Lezon, TR, Boltz, RC, Reese, CE, Wagner, J, Vernetti, LA, Grandis, JR, Lee, AV
Publikováno v:
Grandis, Jennifer; Gough, AH; Chen, N; Shun, TY; Lezon, TR; Boltz, RC; et al.(2014). Identifying and quantifying heterogeneity in high content analysis: Application of heterogeneity indices to drug discovery. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/8zt9r6sz
One of the greatest challenges in biomedical research, drug discovery and diagnostics is understanding how seemingly identical cells can respond differently to perturbagens including drugs for disease treatment. Although heterogeneity has become an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::d5c01bf9056370c6519f980a2e9fe1d6
http://www.escholarship.org/uc/item/8zt9r6sz
http://www.escholarship.org/uc/item/8zt9r6sz
Autor:
Panupinthu, N, Yu, S, Zhang, D, Zhang, F, Gagea, M, Lu, Y, Grandis, JR, Dunn, SE, Lee, HY, Mills, GB
Publikováno v:
Oncogene, vol 33, iss 22
The Y-box binding protein-1 (YB-1) transcription factor is associated with unfavorable clinical outcomes. However, the mechanisms underlying this association remain to be fully elucidated. We demonstrate that YB-1 phosphorylation, indicative of YB-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::40bc7aa383c36dff185a48890f0bfb93
https://escholarship.org/uc/item/06j9c4hp
https://escholarship.org/uc/item/06j9c4hp
Publikováno v:
Grandis, Jennifer; Lei, Y; Lui, VWY; Grandis, JR; & Egloff, AM. (2014). Identification of mutations in the PYRIN-containing NLR genes (NLRP) in head and neck squamous cell carcinoma. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/7m75793n
Head and Neck Squamous Cell Carcinoma (HNSCC) encompasses malignancies that arise in the mucosa of the upper aerodigestive tract. Recent high throughput DNA sequencing revealed HNSCC genes mutations that contribute to several cancer cell characterist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::011d22d61c39aa887afa92cb3a80fb42
http://www.escholarship.org/uc/item/7m75793n
http://www.escholarship.org/uc/item/7m75793n
Publikováno v:
Grandis, Jennifer; Klein, JD; Sano, D; Sen, M; Myers, JN; Grandis, JR; et al.(2014). STAT3 oligonucleotide inhibits tumor angiogenesis in preclinical models of squamous cell carcinoma. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/7944f7b2
Purpose: Signal transducer and activator of transcription 3 (STAT3) has shown to play a critical role in head and neck squamous cell carcinoma (HNSCC) and we have recently completed clinical trials of STAT3 decoy oligonucleotide in patients with recu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::d665ed9657f2cd02fb24ac00a9a562d5
http://www.escholarship.org/uc/item/7944f7b2
http://www.escholarship.org/uc/item/7944f7b2
Publikováno v:
Grandis, Jennifer; Peyser, ND; & Grandis, JR. (2013). Critical analysis of the potential for targeting STAT3 in human malignancy. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/2hw8p64v
The signal transducer and activator of transcription (STAT) family of proteins was originally discovered in the context of normal cell biology where they function to transduce intracellular and extracellular signals to the nucleus, ultimately leading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::d5ec90c8f3dcdbf9f35a5c89504e7301
http://www.escholarship.org/uc/item/2hw8p64v
http://www.escholarship.org/uc/item/2hw8p64v