Zobrazeno 1 - 10
of 481
pro vyhledávání: '"Grandclaudon, P."'
Autor:
Philémon Sirven, Lilith Faucheux, Maximilien Grandclaudon, Paula Michea, Anne Vincent-Salomon, Fatima Mechta-Grigoriou, Alix Scholer-Dahirel, Maude Guillot-Delost, Vassili Soumelis
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-15 (2022)
Abstract Background During cancer development, the normal tissue microenvironment is shaped by tumorigenic events. Inflammatory mediators and immune cells play a key role during this process. However, which molecular features most specifically charac
Externí odkaz:
https://doaj.org/article/301e493c738c45d084ffee93d486fff2
Autor:
Lishan Fang, Dane Ford-Roshon, Max Russo, Casey O’Brien, Xiaozhe Xiong, Carino Gurjao, Maximilien Grandclaudon, Srivatsan Raghavan, Steven M. Corsello, Steven A. Carr, Namrata D. Udeshi, James Berstler, Ewa Sicinska, Kimmie Ng, Marios Giannakis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The RNF43 G659fs mutation occurs frequently in colorectal cancer, but its function remains poorly understood. In this study, the authors show that RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibit
Externí odkaz:
https://doaj.org/article/f27b6baf1c414b9d98b4607879f425b8
Autor:
Caroline Hoffmann, Floriane Noel, Maximilien Grandclaudon, Lucile Massenet-Regad, Paula Michea, Philemon Sirven, Lilith Faucheux, Aurore Surun, Olivier Lantz, Mylene Bohec, Jian Ye, Weihua Guo, Juliette Rochefort, Jerzy Klijanienko, Sylvain Baulande, Charlotte Lecerf, Maud Kamal, Christophe Le Tourneau, Maude Guillot-Delost, Vassili Soumelis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Phenotypic and functional states of dendritic cells critically influence the outcome of cancer and inflammation. Authors here show by single cell transcriptomics and in vitro validation assays that dichotomous PD-L1 and ICOSL expression assign dendri
Externí odkaz:
https://doaj.org/article/3b82b60e8c9c4f308d8dc93c01136700
Autor:
Léa Karpf, Coline Trichot, Lilith Faucheux, Iris Legbre, Maximilien Grandclaudon, Charlotte Lahoute, Hamid Mattoo, Benoit Pasquier, Vassili Soumelis
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-16 (2022)
Abstract Cells receive, and adjust to, various stimuli, which function as part of complex microenvironments forming their “context”. The possibility that a given context impacts the response to a given stimulus defines “context-dependency” an
Externí odkaz:
https://doaj.org/article/ae7b1664246b4a4b8071b7d8f02f4776
Autor:
Karla Fabiola Corral-Jara, Camille Chauvin, Wassim Abou-Jaoudé, Maximilien Grandclaudon, Aurélien Naldi, Vassili Soumelis, Denis Thieffry
Publikováno v:
Molecular Biomedicine, Vol 2, Iss 1, Pp 1-16 (2021)
Abstract Interleukins (IL)-17A and F are critical cytokines in anti-microbial immunity but also contribute to auto-immune pathologies. Recent evidence suggests that they may be differentially produced by T-helper (Th) cells, but the underlying mechan
Externí odkaz:
https://doaj.org/article/12305458a27c4a008a2cff8ad8d21439
Autor:
Floriane Noël, Lucile Massenet-Regad, Irit Carmi-Levy, Antonio Cappuccio, Maximilien Grandclaudon, Coline Trichot, Yann Kieffer, Fatima Mechta-Grigoriou, Vassili Soumelis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Bulk and single-cell transcriptomic data can be a source of novel insights into how cells interact with each other. Here the authors develop ICELLNET, a global, biologically validated, and easy-to-use framework to dissect cell communication from indi
Externí odkaz:
https://doaj.org/article/37f8d252287f4cf6a23fedb4e7518eeb
Autor:
L. Faucheux, M. Grandclaudon, M. Perrot-Dockès, P. Sirven, F. Berger, A.S. Hamy, V. Fourchotte, A. Vincent-Salomon, F. Mechta-Grigoriou, F. Reyal, A. Scholer-Dahirel, M. Guillot-Delost, V. Soumelis
Publikováno v:
OncoImmunology, Vol 8, Iss 9 (2019)
A diversity of T helper (Th) subsets (Th1, Th2, Th17) has been identified in the human tumor microenvironment. In breast cancer, the role of Th subsets remains controversial, and a systematic study integrating Th subset diversity, T cell inflammation
Externí odkaz:
https://doaj.org/article/5ae8203cab4b4848bed3f06e0f136051
Publikováno v:
Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry, Vol 15, Iss 4, Pp 287-296 (2015)
A new technique for the assembly of diversely substituted 3-hydroxy(alkoxy)-3-arylisoindolinones has been developed. This new synthetic route is based upon the anionic cyclization of suitably substituted halogenoaroyl acylamines as the key step and g
Externí odkaz:
https://doaj.org/article/d54b542005b7431587c06fa3296b14c6
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