AXL Inhibition Improves the Antitumor Activity of Chimeric Antigen Receptor T Cells.

Autor: Sakemura RL; T Cell Engineering, Mayo Clinic, Rochester, Minnesota.; Division of Hematology, Mayo Clinic, Rochester, Minnesota., Hefazi M; T Cell Engineering, Mayo Clinic, Rochester, Minnesota.; Division of Hematology, Mayo Clinic, Rochester, Minnesota., Cox MJ; T Cell Engineering, Mayo Clinic, Rochester, Minnesota., Siegler EL; T Cell Engineering, Mayo Clinic, Rochester, Minnesota.; Division of Hematology, Mayo Clinic, Rochester, Minnesota., Sinha S; Division of Hematology, Mayo Clinic, Rochester, Minnesota., Hansen MJ; Department of Immunology, Mayo Clinic, Rochester, Minnesota., Stewart CM; T Cell Engineering, Mayo Clinic, Rochester, Minnesota.; Division of Hematology, Mayo Clinic, Rochester, Minnesota.; Mayo Clinic Graduate School of Biomedical Sciences, Rochester, Minnesota.; Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota., Feigin JM; T Cell Engineering, Mayo Clinic, Rochester, Minnesota., Manriquez Roman C; T Cell Engineering, Mayo Clinic, Rochester, Minnesota.; Division of Hematology, Mayo Clinic, Rochester, Minnesota.; Mayo Clinic Graduate School of Biomedical Sciences, Rochester, Minnesota.; Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota., Schick KJ; T Cell Engineering, Mayo Clinic, Rochester, Minnesota., Can I; T Cell Engineering, Mayo Clinic, Rochester, Minnesota.; Division of Hematology, Mayo Clinic, Rochester, Minnesota., Tapper EE; T Cell Engineering, Mayo Clinic, Rochester, Minnesota., Horvei P; T Cell Engineering, Mayo Clinic, Rochester, Minnesota., Adada MM; T Cell Engineering, Mayo Clinic, Rochester, Minnesota.; Division of Hematology, Mayo Clinic, Rochester, Minnesota., Bezerra ED; T Cell Engineering, Mayo Clinic, Rochester, Minnesota., Kankeu Fonkoua LA; T Cell Engineering, Mayo Clinic, Rochester, Minnesota.; Division of Hematology, Mayo Clinic, Rochester, Minnesota., Ruff MW; T Cell Engineering, Mayo Clinic, Rochester, Minnesota.; Department of Neurology, Mayo Clinic, Rochester, Minnesota., Forsman CL; T Cell Engineering, Mayo Clinic, Rochester, Minnesota., Nevala WK; Department of Immunology, Mayo Clinic, Rochester, Minnesota., Boysen JC; Division of Hematology, Mayo Clinic, Rochester, Minnesota., Tschumper RC; Department of Immunology, Mayo Clinic, Rochester, Minnesota., Grand CL; Sumitomo Dainippon Pharma Oncology, Inc. Lehi, Utah., Kuchimanchi KR; Sumitomo Dainippon Pharma Oncology, Inc. Lehi, Utah., Mouritsen L; Sumitomo Dainippon Pharma Oncology, Inc. Lehi, Utah., Foulks JM; Sumitomo Dainippon Pharma Oncology, Inc. Lehi, Utah., Warner SL; Sumitomo Dainippon Pharma Oncology, Inc. Lehi, Utah., Call TG; Division of Hematology, Mayo Clinic, Rochester, Minnesota., Parikh SA; Division of Hematology, Mayo Clinic, Rochester, Minnesota., Ding W; Division of Hematology, Mayo Clinic, Rochester, Minnesota., Kay NE; Division of Hematology, Mayo Clinic, Rochester, Minnesota., Kenderian SS; T Cell Engineering, Mayo Clinic, Rochester, Minnesota.; Division of Hematology, Mayo Clinic, Rochester, Minnesota.; Department of Immunology, Mayo Clinic, Rochester, Minnesota.; Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota.

Publikováno v: Cancer immunology research [Cancer Immunol Res] 2023 Sep 01; Vol. 11 (9), pp. 1222-1236.

First-Order Methods for Wasserstein Distributionally Robust MDP

Autor: Grand-Cl��ment, Julien, Kroer, Christian

Markov decision processes (MDPs) are known to be sensitive to parameter specification. Distributionally robust MDPs alleviate this issue by allowing for \emph{ambiguity sets} which give a set of possible distributions over parameter sets. The goal is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e393f7ff4be75a27c8b937f2b0e6fd0d
http://arxiv.org/abs/2009.06790

Fibroblast growth receptor 1 is regulated by G-quadruplex in metastatic breast cancer.

Autor: Lin, Hang¹ (AUTHOR), Hassan Safdar, Muhammad¹ (AUTHOR), Washburn, Sarah¹ (AUTHOR), S. Akhand, Saeed¹ (AUTHOR), Dickerhoff, Jonathan¹ (AUTHOR), Ayers, Mitchell¹ (AUTHOR), Monteiro, Marvis^1,2 (AUTHOR), Solorio, Luis^3,4 (AUTHOR), Yang, Danzhou^1,3,5 (AUTHOR) yangdz@purdue.edu, Wendt, Michael K.^1,2,3,6 (AUTHOR) mkwendt@uiowa.edu

Publikováno v: Communications Biology. 8/9/2024, Vol. 7 Issue 1, p1-11. 11p.

Structure–activity relationships for the G-quadruplex-targeting experimental drug QN-302 and two analogues probed with comparative transcriptome profiling and molecular modeling.

Autor: Ahmed, Ahmed Abdullah^1,2 (AUTHOR), Chen, Shuang¹ (AUTHOR), Roman-Escorza, Maria² (AUTHOR), Angell, Richard^1,3 (AUTHOR), Oxenford, Sally^1,4 (AUTHOR), McConville, Matthew⁵ (AUTHOR), Barton, Naomi⁶ (AUTHOR), Sunose, Mihiro⁵ (AUTHOR), Neidle, Dan⁶ (AUTHOR), Haider, Shozeb¹ (AUTHOR), Arshad, Tariq⁷ (AUTHOR), Neidle, Stephen¹ (AUTHOR) s.neidle@ucl.ac.uk

Publikováno v: Scientific Reports. 2/15/2024, Vol. 14 Issue 1, p1-13. 13p.

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