Impact of Reference and Target Region Selection on Amyloid PET SUV Ratios in the Phase 1b PRIME Study of Aducanumab.

Autor: Chiao P; Biogen, Cambridge, Massachusetts ping-chun.chiao@biogen.com., Bedell BJ; Biospective Inc., Montréal, Quebec, Canada.; McGill University, Montréal, Quebec, Canada., Avants B; Biogen, Cambridge, Massachusetts., Zijdenbos AP; Biospective Inc., Montréal, Quebec, Canada., Grand'Maison M; Biospective Inc., Montréal, Quebec, Canada., O'Neill P; Complete Medical Communications, Glasgow, United Kingdom; and., O'Gorman J; Biogen, Cambridge, Massachusetts., Chen T; Biogen, Cambridge, Massachusetts., Koeppe R; University of Michigan, Ann Arbor, Michigan.

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2019 Jan; Vol. 60 (1), pp. 100-106. Date of Electronic Publication: 2018 May 18.

A Kinome-Wide Selective Radiolabeled TrkB/C Inhibitor for in Vitro and in Vivo Neuroimaging: Synthesis, Preclinical Evaluation, and First-in-Human.

Autor: Bernard-Gauthier V; Department of Oncology, Division of Oncological Imaging, University of Alberta , Edmonton, Alberta T6G 2R3, Canada., Bailey JJ; Department of Oncology, Division of Oncological Imaging, University of Alberta , Edmonton, Alberta T6G 2R3, Canada., Mossine AV; Division of Nuclear Medicine, Department of Radiology, The University of Michigan Medical School , Ann Arbor, Michigan 48109, United States., Lindner S; Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich , Marchioninistrasse 15, Munich 81377, Germany., Vomacka L; Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich , Marchioninistrasse 15, Munich 81377, Germany., Aliaga A; Translational Neuroimaging Laboratory, McGill Centre for Studies in Aging, Douglas Mental Health University Institute , 6875 Boulevard LaSalle, Montreal, Quebec H4H 1R3, Canada., Shao X; Division of Nuclear Medicine, Department of Radiology, The University of Michigan Medical School , Ann Arbor, Michigan 48109, United States., Quesada CA; Division of Nuclear Medicine, Department of Radiology, The University of Michigan Medical School , Ann Arbor, Michigan 48109, United States., Sherman P; Division of Nuclear Medicine, Department of Radiology, The University of Michigan Medical School , Ann Arbor, Michigan 48109, United States., Mahringer A; Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg , Heidelberg 69120, Germany., Kostikov A; McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University , 3801 University Street, Montreal, Quebec H3A 2B4, Canada., Grand'Maison M; Biospective Inc. , 6100 Avenue Royalmount, Montreal, Quebec H4P 2R2, Canada., Rosa-Neto P; Translational Neuroimaging Laboratory, McGill Centre for Studies in Aging, Douglas Mental Health University Institute , 6875 Boulevard LaSalle, Montreal, Quebec H4H 1R3, Canada., Soucy JP; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University , 3801 University Street, Montreal, Quebec H3A 2B4, Canada., Thiel A; McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University , 3801 University Street, Montreal, Quebec H3A 2B4, Canada.; Jewish General Hospital, Lady Davis Institute , Montreal, Quebec HT3 1E2, Canada., Kaplan DR; Program in Neurosciences and Mental Health, Hospital for Sick Children , Toronto, Ontario M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto , Toronto, Ontario M5S1A8, Canada., Fricker G; Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg , Heidelberg 69120, Germany., Wängler B; Molecular Imaging and Radiochemistry, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of Heidelberg University , Theodor-Kutzer-Ufer 1-3, Mannheim 68167, Germany., Bartenstein P; Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich , Marchioninistrasse 15, Munich 81377, Germany., Schirrmacher R; Department of Oncology, Division of Oncological Imaging, University of Alberta , Edmonton, Alberta T6G 2R3, Canada., Scott PJH; Division of Nuclear Medicine, Department of Radiology, The University of Michigan Medical School , Ann Arbor, Michigan 48109, United States.; The Interdepartmental Program in Medicinal Chemistry, University of Michigan , Ann Arbor, Michigan 48109, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2017 Aug 24; Vol. 60 (16), pp. 6897-6910. Date of Electronic Publication: 2017 Jul 21.

Brain endothelial TAK1 and NEMO safeguard the neurovascular unit.

Autor: Ridder DA; Institute of Experimental and Clinical Pharmacology and Toxicology and Department of Radiation Oncology, University of Lübeck, 23562 Lübeck, Germany., Wenzel J; Institute of Experimental and Clinical Pharmacology and Toxicology and Department of Radiation Oncology, University of Lübeck, 23562 Lübeck, Germany German Research Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Lübeck/Kiel, 23562 Lübeck, Germany., Müller K; Institute of Experimental and Clinical Pharmacology and Toxicology and Department of Radiation Oncology, University of Lübeck, 23562 Lübeck, Germany., Töllner K; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, 30559 Hannover, Germany Center for Systems Neuroscience, 30559 Hannover, Germany., Tong XK; Montreal Neurological Institute, McGill University, Montreal QC H3A 0G4, Canada., Assmann JC; Institute of Experimental and Clinical Pharmacology and Toxicology and Department of Radiation Oncology, University of Lübeck, 23562 Lübeck, Germany., Stroobants S; Laboratory of Biological Psychology, KU Leuven, 3000 Leuven, Belgium., Weber T; Institute of Experimental and Clinical Pharmacology and Toxicology and Department of Radiation Oncology, University of Lübeck, 23562 Lübeck, Germany., Niturad C; Institute of Experimental and Clinical Pharmacology and Toxicology and Department of Radiation Oncology, University of Lübeck, 23562 Lübeck, Germany., Fischer L; Institute of Experimental and Clinical Pharmacology and Toxicology and Department of Radiation Oncology, University of Lübeck, 23562 Lübeck, Germany., Lembrich B; Institute of Experimental and Clinical Pharmacology and Toxicology and Department of Radiation Oncology, University of Lübeck, 23562 Lübeck, Germany., Wolburg H; Institute of Pathology and Neuropathology, University Hospital Tübingen, 72076 Tübingen, Germany., Grand'Maison M; Montreal Neurological Institute, McGill University, Montreal QC H3A 0G4, Canada., Papadopoulos P; Montreal Neurological Institute, McGill University, Montreal QC H3A 0G4, Canada., Korpos E; Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, 48149 Münster, Germany., Truchetet F; Service de Dermatologie, CHR Metz-Thionville, 57100 Thionville, France., Rades D; Institute of Experimental and Clinical Pharmacology and Toxicology and Department of Radiation Oncology, University of Lübeck, 23562 Lübeck, Germany., Sorokin LM; Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, 48149 Münster, Germany., Schmidt-Supprian M; Department of Hematology and Oncology, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany., Bedell BJ; Montreal Neurological Institute, McGill University, Montreal QC H3A 0G4, Canada., Pasparakis M; Institute for Genetics, University of Cologne, 50674 Cologne, Germany., Balschun D; Laboratory of Biological Psychology, KU Leuven, 3000 Leuven, Belgium., D'Hooge R; Laboratory of Biological Psychology, KU Leuven, 3000 Leuven, Belgium., Löscher W; Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, 30559 Hannover, Germany Center for Systems Neuroscience, 30559 Hannover, Germany., Hamel E; Montreal Neurological Institute, McGill University, Montreal QC H3A 0G4, Canada., Schwaninger M; Institute of Experimental and Clinical Pharmacology and Toxicology and Department of Radiation Oncology, University of Lübeck, 23562 Lübeck, Germany German Research Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Lübeck/Kiel, 23562 Lübeck, Germany markus.schwaninger@pharma.uni-luebeck.de.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2015 Sep 21; Vol. 212 (10), pp. 1529-49. Date of Electronic Publication: 2015 Sep 07.

White matter microstructure is differently associated with executive functioning in youth born with congenital heart disease and youth born preterm.

Autor: Easson, Kaitlyn^1,2 (AUTHOR), Khairy, May³ (AUTHOR), Rohlicek, Charles V.⁴ (AUTHOR), Gilbert, Guillaume⁵ (AUTHOR), Majnemer, Annette^2,6,7 (AUTHOR), Nguyen, Kim‐Anh⁸ (AUTHOR), Luu, Thuy Mai⁹ (AUTHOR), Couture, Élise³ (AUTHOR), Nuyt, Anne‐Monique⁹ (AUTHOR), Deoni, Sean C. L.¹⁰ (AUTHOR), Descoteaux, Maxime^11,12 (AUTHOR), Brossard‐Racine, Marie^1,2,3,6 (AUTHOR) marie.brossardracine@mcgill.ca

Publikováno v: Brain & Behavior. Dec2023, Vol. 13 Issue 12, p1-13. 13p.

The Challenge of Diffusion Magnetic Resonance Imaging in Cerebral Palsy: A Proposed Method to Identify White Matter Pathways.

Autor: Martinie, Ophélie^1,2 (AUTHOR) ophelie.martinie.1@ulaval.ca, Karan, Philippe³ (AUTHOR) philippe.karan@usherbrooke.ca, Traverse, Elodie^1,2 (AUTHOR) elodie.traverse@cirris.ulaval.ca, Mercier, Catherine^1,2 (AUTHOR) catherine.mercier@rea.ulaval.ca, Descoteaux, Maxime³ (AUTHOR) maxime.descoteaux@usherbrooke.ca, Robert, Maxime T.^1,2 (AUTHOR) maxime.robert@fmed.ulaval.ca

Publikováno v: Brain Sciences (2076-3425). Oct2023, Vol. 13 Issue 10, p1386. 20p.