Haloperidol for the Treatment of Delirium in ICU Patients

Autor: Andersen-Ranberg, N.C., Poulsen, L.M., Perner, A., Wetterslev, J., Estrup, S., Hästbacka, J., Morgan, M., Citerio, G., Caballero, J., Lange, T., Kjær, M.-B.N., Ebdrup, B.H., Engstrøm, J., Olsen, M.H., Collet, M. Oxenbøll, Mortensen, C.B., Weber, S.-O., Andreasen, A.S., Bestle, M.H., Uslu, B., Pedersen, H. Scharling, Gramstrup Nielsen, L., Toft Boesen, H.C., Jensen, J.V., Nebrich, L., Cour, K. La, Laigaard, J., Haurum, C., Olesen, M.W., Overgaard-Steensen, C., Westergaard, B., Brand, B.A., Vesterlund, G. Kingo, Kyhnauv, P. Thornberg, Mikkelsen, V.S., Hyttel-Sørensen, S., De Haas, I., Aagaard, S.R., Nielsen, L.O., Eriksen, A.S., Rasmussen, B.S., Brix, H., Hildebrandt, T., Schønemann-Lund, M., Fjeldsøe-Nielsen, H., Kuivalainen, A.-M., Mathiesen, O., Vestergaard, Stine, Bunzel, Anne-Marie, Moulvad, Rine

Publikováno v: Andersen-Ranberg, N C, Poulsen, L M, Perner, A, Wetterslev, J, Estrup, S, Hästbacka, J, Morgan, M, Citerio, G, Caballero, J, Lange, T, Kjær, M-BN, Ebdrup, B H, Engstrøm, J, Olsen, M H, Collet, M O, Mortensen, C B, Weber, S-O, Andreasen, A S, Bestle, M H, Uslu, B, Pedersen, H S, Gramstrup Nielsen, L, Toft Boesen, H C, Jensen, J V, Nebrich, L, Cour, K L, Laigaard, J, Haurum, C, Olesen, M W, Overgaard-Steensen, C, Westergaard, B, Brand, B A, Vesterlund, G K, Kyhnauv, P T, Mikkelsen, V S, Hyttel-Sørensen, S, De Haas, I, Aagaard, S R, Nielsen, L O, Eriksen, A S, Rasmussen, B S, Brix, H, Hildebrandt, T, Schønemann-Lund, M, Fjeldsøe-Nielsen, H, Kuivalainen, A-M, Mathiesen, O, AID-ICU Trial Group, Vestergaard, S, Bunzel, A-M & Moulvad, R 2022, ' Haloperidol for the Treatment of Delirium in ICU Patients ', The New England Journal of Medicine, vol. 387, no. 26, pp. 2425-2435 . https://doi.org/10.1056/NEJMoa2211868
Andersen-Ranberg, N C, Poulsen, L M, Perner, A, Wetterslev, J, Estrup, S, Hästbacka, J, Morgan, M, Citerio, G, Caballero, J, Lange, T, Kjær, M B N, Ebdrup, B H, Engstrøm, J, Olsen, M H, Oxenbøll Collet, M, Mortensen, C B, Weber, S O, Andreasen, A S, Bestle, M H, Uslu, B, Scharling Pedersen, H, Gramstrup Nielsen, L, Toft Boesen, H C, Jensen, J V, Nebrich, L, La Cour, K, Laigaard, J, Haurum, C, Olesen, M W, Overgaard-Steensen, C, Westergaard, B, Brand, B, Kingo Vesterlund, G, Thornberg Kyhnauv, P, Mikkelsen, V S, Hyttel-Sørensen, S, de Haas, I, Aagaard, S R, Nielsen, L O, Eriksen, A S, Rasmussen, B S, Brix, H, Hildebrandt, T, Schønemann-Lund, M, Fjeldsøe-Nielsen, H, Kuivalainen, A M, Mathiesen, O & AID-ICU Trial Group 2022, ' Haloperidol for the Treatment of Delirium in ICU Patients ', The New England Journal of Medicine, vol. 387, no. 26, pp. 2425-2435 . https://doi.org/10.1056/NEJMoa2211868
Andersen-Ranberg, N C, Poulsen, L M, Perner, A, Wetterslev, J, Estrup, S, Haestbacka, J, Morgan, M, Citerio, G, Caballero, J, Lange, T, Kjaer, M-B N, Ebdrup, B H, Engstrom, J, Olsen, M H, Oxenboll Collet, M, Mortensen, C B, Weber, S-O, Andreasen, A S, Bestle, M H, Uslu, B, Scharling Pedersen, H, Gramstrup Nielsen, L, Toft Boesen, H C, Jensen, J V, Nebrich, L, La Cour, K, Laigaard, J, Haurum, C, Olesen, M W, Overgaard-Steensen, C, Westergaard, B, Brand, B A, Kingo Vesterlund, G, Thornberg Kyhnauv, P, Mikkelsen, V S, Hyttel-Sorensen, S, de Haas, I, Aagaard, S R, Nielsen, L O, Eriksen, A S, Rasmussen, B S, Brix, H, Hildebrandt, T, Schonemann-Lund, M, Fjeldsoe-Nielsen, H, Kuivalainen, A-M, Mathiesen, O & AID ICU Trial Grp 2022, ' Haloperidol for the Treatment of Delirium in ICU Patients ', New England Journal of Medicine, vol. 387, no. 20, pp. 2425-2435 . https://doi.org/10.1056/NEJMoa2211868

Background: Haloperidol is frequently used to treat delirium in patients in the intensive care unit (ICU), but evidence of its effect is limited.Methods: In this multicenter, blinded, placebo-controlled trial, we randomly assigned adult patients with

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https://pubmed.ncbi.nlm.nih.gov/36286254