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Akademický článek

Isoform-Specific Effects of Apolipoprotein E on Markers of Inflammation and Toxicity in Brain Glia and Neuronal Cells In Vitro

Autor: Jaclyn Iannucci, Abhik Sen, Paula Grammas

Publikováno v: Current Issues in Molecular Biology, Vol 43, Iss 1, Pp 215-225 (2021)

Mutations to the cholesterol transport protein apolipoprotein E (ApoE) have been identified as a major risk factor for the development of sporadic or late-onset Alzheimer’s disease (AD), with the e4 allele representing an increased risk and the rar

Externí odkaz: https://doaj.org/article/1a2823261b964972accd80c50d1493a8

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Akademický článek

Thrombin, a Key Driver of Pathological Inflammation in the Brain

Autor: Jaclyn Iannucci, Paula Grammas

Publikováno v: Cells, Vol 12, Iss 9, p 1222 (2023)

Neurodegenerative diseases, including Alzheimer’s disease (AD), are major contributors to death and disability worldwide. A multitude of evidence suggests that neuroinflammation is critical in neurodegenerative disease processes. Exploring the key

Externí odkaz: https://doaj.org/article/2d153eb7759349fe80fd05755511c708

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Akademický článek

Dabigatran reduces thrombin-induced neuroinflammation and AD markers in vitro: Therapeutic relevance for Alzheimer's disease

Autor: Syed Waseem Bihaqi, Haripriya Vittal Rao, Abhik Sen, Paula Grammas

Publikováno v: Cerebral Circulation - Cognition and Behavior, Vol 2, Iss , Pp 100014- (2021)

Background: Vascular risk factors such as atherosclerosis, diabetes, and elevated homocysteine levels are strongly correlated with onset of Alzheimer's disease (AD). Emerging evidence indicates that blood coagulation protein thrombin is associated wi

Externí odkaz: https://doaj.org/article/c2c83101daef4c86bf2e9b6a1b98fcd5

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Akademický článek

Short-term treatment with dabigatran alters protein expression patterns in a late-stage tau-based Alzheimer's disease mouse model

Autor: Jaclyn Iannucci, Shelby L. Johnson, Mark Majchrzak, Benjamin J. Barlock, Fatemeh Akhlaghi, Navindra P. Seeram, Abhik Sen, Paula Grammas

Publikováno v: Biochemistry and Biophysics Reports, Vol 24, Iss , Pp 100862- (2020)

Proteins that regulate the coagulation cascade, including thrombin, are elevated in the brains of Alzheimer's disease (AD) patients. While studies using amyloid-based AD transgenic mouse models have implicated thrombin as a protein of interest, the r

Externí odkaz: https://doaj.org/article/03ac6d10deab459f80d89734a98f9d4e

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Akademický článek

Thrombin, a Mediator of Coagulation, Inflammation, and Neurotoxicity at the Neurovascular Interface: Implications for Alzheimer’s Disease

Autor: Jaclyn Iannucci, William Renehan, Paula Grammas

Publikováno v: Frontiers in Neuroscience, Vol 14 (2020)

The societal burden of Alzheimer’s disease (AD) is staggering, with current estimates suggesting that 50 million people world-wide have AD. Identification of new therapeutic targets is a critical barrier to the development of disease-modifying ther

Externí odkaz: https://doaj.org/article/d39585a673324588b103198c5643ff1e

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Akademický článek

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Akademický článek

Blood-Cerebrospinal Fluid Barrier Gradients in Mild Cognitive Impairment and Alzheimer's Disease: Relationship to Inflammatory Cytokines and Chemokines

Autor: Brian R. Ott, Richard N. Jones, Lori A. Daiello, Suzanne M. de la Monte, Edward G. Stopa, Conrad E. Johanson, Charles Denby, Paula Grammas

Publikováno v: Frontiers in Aging Neuroscience, Vol 10 (2018)

Background: The pathophysiology underlying altered blood-cerebrospinal fluid barrier (BCSFB) function in Alzheimer's disease (AD) is unknown but may relate to endothelial cell activation and cytokine mediated inflammation.Methods: Cerebrospinal fluid

Externí odkaz: https://doaj.org/article/89cdffa1cdd74c17b913398e9c3a9283

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