Proteogenomics of non-small cell lung cancer reveals molecular subtypes associated with specific therapeutic targets and immune evasion mechanisms.

Autor: Lehtiö J; Department of Oncology and Pathology, Karolinska Institutet, SciLifeLab, Solna, Sweden. janne.lehtio@ki.se., Arslan T; Department of Oncology and Pathology, Karolinska Institutet, SciLifeLab, Solna, Sweden., Siavelis I; Department of Oncology and Pathology, Karolinska Institutet, SciLifeLab, Solna, Sweden., Pan Y; Department of Oncology and Pathology, Karolinska Institutet, SciLifeLab, Solna, Sweden., Socciarelli F; Department of Oncology and Pathology, Karolinska Institutet, SciLifeLab, Solna, Sweden., Berkovska O; Department of Oncology and Pathology, Karolinska Institutet, SciLifeLab, Solna, Sweden., Umer HM; Department of Oncology and Pathology, Karolinska Institutet, SciLifeLab, Solna, Sweden., Mermelekas G; Department of Oncology and Pathology, Karolinska Institutet, SciLifeLab, Solna, Sweden., Pirmoradian M; Department of Oncology and Pathology, Karolinska Institutet, SciLifeLab, Solna, Sweden., Jönsson M; Division of Oncology, Department of Clinical Sciences, Lund and CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden., Brunnström H; Department of Pathology, Laboratory Medicine Region Skåne, Lund, Sweden.; Division of Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden., Brustugun OT; Section of Oncology, Drammen Hospital, Vestre Viken Health Trust, Drammen, Norway.; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway., Purohit KP; University of Edinburgh Centre for Inflammation Research, Institute for Regeneration and Repair, Queen's Medical Research Institute, Edinburgh bioQuarter, Edinburgh, UK.; MRC Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Cunningham R; University of Edinburgh Centre for Inflammation Research, Institute for Regeneration and Repair, Queen's Medical Research Institute, Edinburgh bioQuarter, Edinburgh, UK.; MRC Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Foroughi Asl H; Genomic Medicine Center, Karolinska University Hospital, Stockholm, Sweden.; Clinical Genomics Facility, Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, Stockholm, Sweden., Isaksson S; Division of Oncology, Department of Clinical Sciences, Lund and CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden., Arbajian E; Division of Oncology, Department of Clinical Sciences, Lund and CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden., Aine M; Division of Oncology, Department of Clinical Sciences, Lund and CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden., Karlsson A; Division of Oncology, Department of Clinical Sciences, Lund and CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden., Kotevska M; Division of Oncology, Department of Clinical Sciences, Lund and CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden.; Department of Respiratory Medicine and Allergology, Skåne University Hospital, Lund, Sweden., Gram Hansen C; University of Edinburgh Centre for Inflammation Research, Institute for Regeneration and Repair, Queen's Medical Research Institute, Edinburgh bioQuarter, Edinburgh, UK.; MRC Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Drageset Haakensen V; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.; Department of Oncology, Oslo University Hospital, Oslo, Norway., Helland Å; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.; Department of Oncology, Oslo University Hospital, Oslo, Norway.; Faculty of Medicine, University of Oslo, Oslo, Norway., Tamborero D; Department of Oncology and Pathology, Karolinska Institutet, SciLifeLab, Solna, Sweden., Johansson HJ; Department of Oncology and Pathology, Karolinska Institutet, SciLifeLab, Solna, Sweden., Branca RM; Department of Oncology and Pathology, Karolinska Institutet, SciLifeLab, Solna, Sweden., Planck M; Division of Oncology, Department of Clinical Sciences, Lund and CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden.; Department of Respiratory Medicine and Allergology, Skåne University Hospital, Lund, Sweden., Staaf J; Division of Oncology, Department of Clinical Sciences, Lund and CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden., Orre LM; Department of Oncology and Pathology, Karolinska Institutet, SciLifeLab, Solna, Sweden.

Publikováno v: Nature cancer [Nat Cancer] 2021 Nov; Vol. 2 (11), pp. 1224-1242. Date of Electronic Publication: 2021 Nov 22.

TAZ facilitates breast tumor growth by promoting an immune‐suppressive tumor microenvironment.

Autor: Gershoni, Anat, Hassin, Ori, Nataraj, Nishanth Belugali, Baruch, Sivan, Avioz‐Seligman, Adi, Pirona, Anna Chiara, Fellus‐Alyagor, Liat, Meir Salame, Tomer, Mukherjee, Saptaparna, Mallel, Giuseppe, Yarden, Yosef, Aylon, Yael, Oren, Moshe

Publikováno v: Molecular Oncology; Dec2023, Vol. 17 Issue 12, p2675-2693, 19p

Proteogenomics of non-small cell lung cancer reveals molecular subtypes associated with specific therapeutic targets and immune evasion mechanisms

Autor: Henrik J. Johansson, Marija Kotevska, Rui M. M. Branca, Sofi Isaksson, Krishna Pinganksha Purohit, Carsten G. Hansen, Mohammad Pirmoradian, Georgios Mermelekas, Odd Terje Brustugun, Olena Berkovska, David Tamborero, Richard Cunningham, Husen M. Umer, Janne Lehtiö, Yanbo Pan, Maria Planck, Åslaug Helland, Lukas M. Orre, Fabio Socciarelli, Taner Arslan, Anna Karlsson, Mats Jönsson, Elsa Arbajian, Hassan Foroughi Asl, Vilde Drageset Haakensen, Ioannis Siavelis, Mattias Aine, Johan Staaf, Hans Brunnström

Publikováno v: Nature Cancer
Lehtiö, J, Arslan, T, Siavelis, I, Pan, Y, Socciarelli, F, Berkovska, O, Umer, H M, Mermelekas, G, Pirmoradian, M, Jönsson, M, Brunnström, H, Brustugun, O T, Purohit, K P, Cunningham, R, Foroughi Asl, H, Isaksson, S, Arbajian, E, Aine, M, Karlsson, A, Kotevska, M, Gram Hansen, C, Drageset Haakensen, V, Helland, Å, Tamborero, D, Johansson, H J, Branca, R M, Planck, M, Staaf, J & Orre, L M 2021, ' Proteogenomics of non-small cell lung cancer reveals molecular subtypes associated with specific therapeutic targets and immune-evasion mechanisms ', nature cancer, vol. 2, no. 11, pp. 1224-1242 . https://doi.org/10.1038/s43018-021-00259-9

Despite major advancements in lung cancer treatment, long-term survival is still rare and a deeper understanding of molecular phenotypes would allow the identification of specific cancer dependencies and immune-evasion mechanisms. Here we performed i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8af0d696185c5ea5334a160bc13b493

Dissection of an Allosteric Mechanism on the Serotonin Transporter: A Cross-Species Study

Autor: Carsten G. Hansen, Ove Wiborg, Henrik Amtoft Neubauer

Publikováno v: Neubauer, H A, Gram Hansen, C & Wiborg, O 2006, ' Dissection of an allosteric mechanism on the serotonin transporter: a cross-species study ', Molecular Pharmacology, vol. 69, no. 4, pp. 1242-1250 .

The serotonin transporter (SERT), which belongs to a family of sodium/chloride-dependent transporters, is the major pharmacological target in the treatment of several clinical disorders, including depression and anxiety. Interaction with a low-affini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ece33d4dedd68310a312cd81e8e8239
https://doi.org/10.1124/mol.105.018507