Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Grainne M. McAlonan"'
Autor:
Tobias P. Whelan, Eileen Daly, Nicolaas A. Puts, Paula Smith, Carrie Allison, Simon Baron-Cohen, Ekaterina Malievskaia, Declan G. M. Murphy, Grainne M. McAlonan
Publikováno v:
BMC Psychiatry, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background The underlying neurobiology of the complex autism phenotype remains obscure, although accumulating evidence implicates the serotonin system and especially the 5HT2A receptor. However, previous research has largely relied upon asso
Externí odkaz:
https://doaj.org/article/cfecf35bb67a407984c82a33eb4ceb24
Autor:
Charlotte E. Blackmore, Alexandra Nolan, Vladimira Stoencheva, Natalie Greenwood, Natasha Liu-Thwaites, Stefanos Maltezos, Grainne M. McAlonan
Publikováno v:
BJPsych Open, Vol 9 (2023)
Background Restrictions on in-person assessments during the COVID-19 pandemic were a challenge for an adult autism diagnostic service receiving over 600 referrals annually. The service sought to adapt the Autism Diagnostic Observation Schedule (ADOS-
Externí odkaz:
https://doaj.org/article/5bbfa9108b67433a9c1f7b704681ce63
Autor:
Prachi A. Patkee, Ana A. Baburamani, Katherine R. Long, Ralica Dimitrova, Judit Ciarrusta, Joanna Allsop, Emer Hughes, Johanna Kangas, Grainne M. McAlonan, Mary A. Rutherford, Enrico De Vita
Publikováno v:
Neurobiology of Disease, Vol 153, Iss , Pp 105316- (2021)
The neurodevelopmental phenotype in Down Syndrome (DS), or Trisomy 21, is variable including a wide spectrum of cognitive impairment and a high risk of early-onset Alzheimer's disease (AD). A key metabolite of interest within the brain in DS is Myo-i
Externí odkaz:
https://doaj.org/article/b0515f8529bf477282148b5946f6fdce
Autor:
Yanez Lopez Maria, Anthony N. Price, Nicolaas A.J. Puts, Emer J. Hughes, Richard A.E. Edden, Grainne M. McAlonan, Tomoki Arichi, Enrico De Vita
Publikováno v:
NeuroImage, Vol 233, Iss , Pp 117930- (2021)
Balance between inhibitory and excitatory neurotransmitter systems and the protective role of the major antioxidant glutathione (GSH) are central to early healthy brain development. Disruption has been implicated in the early life pathophysiology of
Externí odkaz:
https://doaj.org/article/a41cccde7d4449f0a82f0a1ca620bf9e
Autor:
Vaheshta Sethna, Jasmine Siew, Inês Pote, Siying Wang, Maria Gudbrandsen, Charlotte Lee, Emily Perry, Kerrie P.H. Adams, Clare Watson, Johanna Kangas, Vladimira Stoencheva, Eileen Daly, Maria Kuklisova-Murgasova, Steven C.R. Williams, Michael C. Craig, Declan G.M. Murphy, Grainne M. McAlonan
Publikováno v:
Developmental Cognitive Neuroscience, Vol 40, Iss , Pp - (2019)
Fathers play a crucial role in their children’s socio-emotional and cognitive development. A plausible intermediate phenotype underlying this association is father’s impact on infant brain. However, research on the association between paternal ca
Externí odkaz:
https://doaj.org/article/48daa56ec51947c0b0d87fd69bac7651
Publikováno v:
Data in Brief, Vol 26, Iss , Pp - (2019)
DNA methylation is a dynamic epigenetic mark regulating gene function and are implicated in the pathophysiology of schizophrenia and autism. Environmental exposures such as inflammation and diet modify the epigenome and may explain why prenatal expos
Externí odkaz:
https://doaj.org/article/9609733add64433fafd600d82f592b60
Publikováno v:
Data in Brief, Vol 25, Iss , Pp - (2019)
Prenatal exposure to infection and inflammation increases the risk of neurodevelopmental disorders such as schizophrenia and autism. The etiology could be partly through transgenerational and modifiable DNA methylation changes in the adult offspring'
Externí odkaz:
https://doaj.org/article/39c7a2d23ee5489f9c4848d41603978b
Autor:
Tobias P. Whelan, Eileen Daly, Nicolaas A. Puts, Ekaterina Malievskaia, Declan G.M. Murphy, Grainne M. McAlonan
Clinical trials of pharmacological approaches targeting the core features of autism have failed. This is despite evidence from preclinical studies, genetics, post-mortem studies and correlational analyses linking peripheral and central markers of mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c242416401a689dccc9a96a44b56fa57
https://doi.org/10.1101/2023.05.25.23290521
https://doi.org/10.1101/2023.05.25.23290521
Autor:
Nichol ML Wong, Ottavia Dipasquale, Federico Turkheimer, James L Findon, Robert H Wichers, Mihail Dimitrov, Clodagh M Murphy, Vladimira Stoencheva, Dene M Robertson, Declan G Murphy, Eileen Daly, Grainne M McAlonan
Publikováno v:
Journal of Psychopharmacology. 36:723-731
Background: Alterations in the serotonergic control of brain pathways responsible for facial emotion processing in people with autism spectrum disorder (ASD) may be a target for intervention. However, the molecular underpinnings of autistic-neurotypi
Autor:
Sophie Arulkumaran, Emer Hughes, Shona Falconer, Emma C. Robinson, Andrew Chew, Teixeira Rpag., Daniel Rueckert, Johannes K. Steinweg, Olivia Carney, Andreas Schuh, Dafnis Batalle, Joseph V. Hajnal, Serena J. Counsell, Judit Ciarrusta, Mary A. Rutherford, Grainne M. McAlonan, Ralica Dimitrova, Jonathan O'Muircheartaigh, Katy Vecchiato, Alexander D. Edwards, Russell Macleod, Jana Hutter, Stephen M. Smith, Alexia Egloff, Andre F. Marquand, Thomas Wolfers, Lucilio Cordero-Grande, Anthony N. Price, Antonios Makropoulos
Publikováno v:
Cerebral Cortex (New York, NY)
Dimitrova, R, Arulkumaran, S, Carney, O, Chew, A, Falconer, S, Ciarrusta, J, Wolfers, T, Batalle, D, Cordero-Grande, L, Price, A N, Teixeira, R P A G, Hughes, E, Egloff, A, Hutter, J, Makropoulos, A, Robinson, E C, Schuh, A, Vecchiato, K, Steinweg, J K, Macleod, R, Marquand, A F, McAlonan, G, Rutherford, M A, Counsell, S J, Smith, S M, Rueckert, D, Hajnal, J V, O'Muircheartaigh, J & Edwards, A D 2021, ' Phenotyping the Preterm Brain : Characterizing Individual Deviations from Normative Volumetric Development in Two Large Infant Cohorts ', Cerebral Cortex, vol. 31, no. 8, pp. 3665-3677 . https://doi.org/10.1093/cercor/bhab039
Dimitrova, R, Arulkumaran, S, Carney, O, Chew, A, Falconer, S, Ciarrusta, J, Wolfers, T, Batalle, D, Cordero-Grande, L, Price, A N, Teixeira, R P A G, Hughes, E, Egloff, A, Hutter, J, Makropoulos, A, Robinson, E C, Schuh, A, Vecchiato, K, Steinweg, J K, Macleod, R, Marquand, A F, McAlonan, G, Rutherford, M A, Counsell, S J, Smith, S M, Rueckert, D, Hajnal, J V, O'Muircheartaigh, J & Edwards, A D 2021, ' Phenotyping the Preterm Brain : Characterizing Individual Deviations from Normative Volumetric Development in Two Large Infant Cohorts ', Cerebral Cortex, vol. 31, no. 8, pp. 3665-3677 . https://doi.org/10.1093/cercor/bhab039
The diverse cerebral consequences of preterm birth create significant challenges for understanding pathogenesis or predicting later outcome. Instead of focusing on describing effects common to the group, comparing individual infants against robust no