Zobrazeno 1 - 10
of 203
pro vyhledávání: '"Grainne M, O'Kane"'
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
Targeting the RAS pathway remains the holy grail of precision oncology. In the case of pancreatic ductal adenocarcinomas (PDAC), 90–92% harbor mutations in the oncogene KRAS, triggering canonical MAPK signaling. The smooth structure of the altered
Externí odkaz:
https://doaj.org/article/df90e00437fb426884e59d706b84c124
Autor:
Joan Miguel Romero, Emma Titmuss, Yifan Wang, James Vafiadis, Alain Pacis, Gun Ho Jang, Amy Zhang, Bryn Golesworthy, Tatiana Lenko, Laura M. Williamson, Barbara Grünwald, Grainne M. O’Kane, Steven J. M. Jones, Marco. A. Marra, Julie M. Wilson, Steven Gallinger, Janessa Laskin, George Zogopoulos
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-14 (2023)
Abstract Immune checkpoint inhibitors (ICI) are highly effective in specific cancers where canonical markers of antitumor immunity are used for patient selection. Improved predictors of T cell-inflammation are needed to identify ICI-responsive tumor
Externí odkaz:
https://doaj.org/article/8dd7df9c6c22430ba3c3588f08acd012
Autor:
Jannat Pervin, Mohammad Asad, Shaolong Cao, Gun Ho Jang, Nikta Feizi, Benjamin Haibe-Kains, Joanna M. Karasinska, Grainne M. O’Kane, Steven Gallinger, David F. Schaeffer, Daniel J. Renouf, George Zogopoulos, Oliver F. Bathe
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Background: Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease characterized by a diverse tumor microenvironment. The heterogeneous cellular composition of PDAC makes it challenging to study molecular features of tumor cells using extracts f
Externí odkaz:
https://doaj.org/article/ec92d12728a044ddbf9be245d2f7b7e0
Autor:
James T. Topham, Erica S. Tsang, Joanna M. Karasinska, Andrew Metcalfe, Hassan Ali, Steve E. Kalloger, Veronika Csizmok, Laura M. Williamson, Emma Titmuss, Karina Nielsen, Gian Luca Negri, Sandra E. Spencer Miko, Gun Ho Jang, Robert E. Denroche, Hui-li Wong, Grainne M. O’Kane, Richard A. Moore, Andrew J. Mungall, Jonathan M. Loree, Faiyaz Notta, Julie M. Wilson, Oliver F. Bathe, Patricia A. Tang, Rachel Goodwin, Gregg B. Morin, Jennifer J. Knox, Steven Gallinger, Janessa Laskin, Marco A. Marra, Steven J. M. Jones, David F. Schaeffer, Daniel J. Renouf
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
KRAS wildtype metastatic pancreatic ductal adenocarcinoma (mPDAC) could represent a distinct molecular entity from other PDACs. Here, the authors analyse KRAS wildtype mPDAC tumours using genomics and transcriptomics and find molecular similarities w
Externí odkaz:
https://doaj.org/article/14e83fbde8ea418ebe058f1c83ca1f44
Autor:
Kai Duan, Gun-Ho Jang, Robert C. Grant, Julie M. Wilson, Faiyaz Notta, Grainne M. O’Kane, Jennifer J. Knox, Steven Gallinger, Sandra Fischer
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Combination chemotherapy, either modified FOLFIRINOX (mFFX) or gemcitabine–nabpaclitaxel, are used in the treatment of most patients with advanced pancreatic ductal adenocarcinoma (PDAC), yet robust biomarkers of outcome are currently lack
Externí odkaz:
https://doaj.org/article/73ccc66b28ee408c885e22f743c92bee
Autor:
Bryn Golesworthy, Yifan Wang, Amanda Tanti, Alain Pacis, Joan Miguel Romero, Adeline Cuggia, Celine Domecq, Guillaume Bourdel, Robert E. Denroche, Gun Ho Jang, Robert C. Grant, Ayelet Borgida, Barbara T. Grünwald, Anna Dodd, Julie M. Wilson, Guillaume Bourque, Grainne M. O’Kane, Sandra E. Fischer, Chelsea Maedler Kron, Pierre-Olivier Fiset, Atilla Omeroglu, William D. Foulkes, Steven Gallinger, Marie-Christine Guiot, Zu-Hua Gao, George Zogopoulos
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The immune contexture of pancreatic ductal adenocarcinoma (PDAC) is generally immunosuppressive. A role for immune checkpoint inhibitors (ICIs) in PDAC has only been demonstrated for the rare and hypermutated mismatch repair (MMR) deficient (MMR-d) s
Externí odkaz:
https://doaj.org/article/05e7545055d64a62972ea705edc792bf
Autor:
Shirley Xue Jiang, Ryan N. Walton, Katrina Hueniken, Justine Baek, Alexandra McCartney, Catherine Labbé, Elliot Smith, Sze Wah Samuel Chan, RuiQi Chen, Catherine Brown, Devalben Patel, Mindy Liang, Lawson Eng, Adrian Sacher, Penelope Bradbury, Natasha B. Leighl, Frances A. Shepherd, Wei Xu, Geoffrey Liu, Manjusha Hurry, Grainne M. O'Kane
Publikováno v:
Cancer Medicine, Vol 8, Iss 18, Pp 7542-7555 (2019)
Abstract Background As the treatment landscape in patients with non‐small cell lung cancer (NSCLC) harboring mutations in the epidermal growth factor receptor (EGFRm) continues to evolve, real‐world health utility scores (HUS) become increasingly
Externí odkaz:
https://doaj.org/article/c847915c6e9a44aea2fbbc380f249647
Autor:
Lucy X. Ma, Yifan Wang, Osvaldo Espin-Garcia, Michael J. Allen, Gun Ho Jang, Amy Zhang, Anna Dodd, Stephanie Ramotar, Shawn Hutchinson, Mustapha Tehfe, Ravi Ramjeesingh, James Biagi, Julie M. Wilson, Faiyaz Notta, Sandra E. Fischer, George Zogopoulos, Steven Gallinger, Robert C. Grant, Rama Khokha, Nathan Chan, Barbara T. Grünwald, Jennifer J. Knox, Grainne M. O’Kane
Publikováno v:
British Journal of Cancer. 128:1916-1921
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bca148ea02eb21806d86de2e65a161c8
https://doi.org/10.1038/s41416-023-02214-0
https://doi.org/10.1038/s41416-023-02214-0
Autor:
Woo Jin Choi, Tommy Ivanics, Annabel Gravely, Steven Gallinger, Gonzalo Sapisochin, Grainne M. O’Kane
Publikováno v:
Annals of Surgical Oncology. 30:3849-3863
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d6b7b4d0e605c18a268d0eaa4784cac
https://doi.org/10.1245/s10434-023-13126-x
https://doi.org/10.1245/s10434-023-13126-x
Autor:
Nicholas Holzapfel, Amy Zhang, Woo-Jin Choi, Robert Denroche, Gunho Jang, Anna Dodd, Roxana Bucur, Julie Wilson, Gonzalo Sapisochin, Faiyaz Notta, Robert C. Grant, Steven Gallinger, Jennifer J. Knox, Grainne M. O’Kane
Publikováno v:
Journal of Gastrointestinal Oncology. 14:379-389
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::757834b11b9fc6aab52a3266eef62b1f
https://doi.org/10.21037/jgo-22-676
https://doi.org/10.21037/jgo-22-676