Acute effects of cannabinoids on addiction endophenotypes are moderated by genes encoding the CB1 receptor and FAAH enzyme

Autor: Grainne Schafer, Tom P. Freeman, Celia J. A. Morgan, Michael A P Bloomfield, Chandni Hindocha, H. Valerie Curran, Chelsea Gardner, Elvira Bramon

Publikováno v: Hindocha, C, Freeman, T P, Schafer, G, Gardner, C, Bloomfield, M A P, Bramon, E, Morgan, C J A & Curran, H V 2020, ' Acute effects of cannabinoids on addiction endophenotypes are moderated by genes encoding the CB1 receptor and FAAH enzyme ', Addiction Biology, vol. 25, no. 3, e12762 . https://doi.org/10.1111/adb.12762

Understanding genetic factors that contribute to cannabis use disorder (CUD) is important, but to date, findings have been equivocal. Single-nucleotide polymorphisms (SNPs) in the cannabinoid receptor 1 gene (CNR1; rs1049353 and rs806378) and fatty a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::564de97e697fe9b889519a1fd1b3cee0
https://pubmed.ncbi.nlm.nih.gov/31013550

Just say ‘know’: how do cannabinoid concentrations influence users' estimates of cannabis potency and the amount they roll in joints?

Autor: Grainne Schafer, Ravi K. Das, Tom P. Freeman, Celia J. A. Morgan, H. Valerie Curran, Chandni Hindocha

Publikováno v: Addiction. 109:1686-1694

Aims (1) To determine whether measured concentrations of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in individuals' own cannabis predict their estimates of drug potency and actual titration; and (2) to ascertain if these effects are inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9ab5192f58e28259c50c9be286082b0
https://doi.org/10.1111/add.12634

Sub-chronic impact of cannabinoids in street cannabis on cognition, psychotic-like symptoms and psychological well-being

Autor: I. Rupasinghe, Grainne Schafer, Gail Wingham, S. Lewis, A. Ramoutar, C. Gardener, Tom P. Freeman, Sarah Swan, Celia Demarchi, HV Curran, N. Tan, Celia J. A. Morgan, P. Warrington

Publikováno v: Psychological Medicine. 42:391-400

BackgroundCannabis varies considerably in levels of its two major constituent cannabinoids – (delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Recently, we found evidence that those who smoked cannabis containing detectable levels of CBD h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52af120a3c57da6a00ec326908a02fae
https://doi.org/10.1017/s0033291711001322

Associations between cigarette smoking and cannabis dependence: a longitudinal study of young cannabis users in the United Kingdom

Autor: Chandni, Hindocha, Natacha D C, Shaban, Tom P, Freeman, Ravi K, Das, Grace, Gale, Grainne, Schafer, Caroline J, Falconer, Celia J A, Morgan, H Valerie, Curran

Publikováno v: Drug and Alcohol Dependence

Highlights • We studied the extent that cigarette smoking predicts level of cannabis addiction. • We tested whether cigarette smoking mediates the effect of cannabis use on dependence. • We interviewed 298 cannabis and tobacco users, of which 6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6ca32e974ff0a3e4b50ab3efe17121f1
https://pubmed.ncbi.nlm.nih.gov/25622777

Cannabidiol attenuates the appetitive effects of Delta 9-tetrahydrocannabinol in humans smoking their chosen cannabis

Autor: Grainne Schafer, H. Valerie Curran, Tom P. Freeman, Celia J. A. Morgan

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 35(9)

Worldwide cannabis dependence is increasing, as is the concentration of Delta(9)-tetrahydrocannabinol (THC) in street cannabis. At the same time, the concentration of the second most abundant cannabinoid in street cannabis, cannabidiol (CBD), is decr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2edbb523ed992fadb89a14e40ae310d
https://pubmed.ncbi.nlm.nih.gov/20428110