Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Grahame J. McKenzie"'
Autor:
David J. Huggins, Bryn S. Hardwick, Pooja Sharma, Amy Emery, Luca Laraia, Fengzhi Zhang, Ana J. Narvaez, Meredith Roberts-Thomson, Alex T. Crooks, Robert G. Boyle, Richard Boyce, David W. Walker, Natalia Mateu, Grahame J. McKenzie, David R. Spring, Ashok R. Venkitaraman
Publikováno v:
ACS Omega, Vol 5, Iss 1, Pp 822-831 (2019)
Externí odkaz:
https://doaj.org/article/3fe07deb35644870ad3f7fc29a93ca5e
Autor:
Chris Abell, Kalina T. Haas, Matthias T. Ehebauer, Luca Pellegrini, Amy Emery, May Marsh, David J. Huggins, Chiara R. Valenzano, Tom L. Blundell, Ashok R. Venkitaraman, Bryn Hardwick, Miyoung Lee, Lorraine Barber, Timothy Sharpe, Rajavel Srinivasan, John Skidmore, Nicola J. Francis-Newton, Alessandro Esposito, Duncan Scott, Claudio Dagostin, Marko Hyvönen, Gerhard Fischer, Andrew R. Bayly, Grahame J. McKenzie, Trevor Perrior, Tommaso Moschetti, Anthony G. Coyne
Publikováno v:
Cell Chemical Biology
'Cell Chemical Biology ', vol: 28, pages: 835-847 (2021)
'Cell Chemical Biology ', vol: 28, pages: 835-847 (2021)
Summary BRCA2 controls RAD51 recombinase during homologous DNA recombination (HDR) through eight evolutionarily conserved BRC repeats, which individually engage RAD51 via the motif Phe-x-x-Ala. Using structure-guided molecular design, templated on a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e8b51ead91fb6e0441f1e51a013c4f
Autor:
Gerhard Fischer, Matthias T. Ehebauer, Luca Pellegrini, Marko Hyvönen, David J. Huggins, Chiara R. Valenzano, Ashok R. Venkitaraman, Rajavel Srinivasan, Timothy Sharpe, Anthony G. Coyne, Alessandro Esposito, Duncan Scott, Tommaso Moschetti, Kalina T. Haas, Chris Abell, May Marsh, John Skidmore, Andrew R. Bayly, Grahame J. McKenzie, Lorraine Barber, Trevor Perrior, Tom L. Blundell, Nicola J. Francis-Newton
SUMMARYBRCA2 controls RAD51 recombinase during homologous DNA recombination (HDR) through eight evolutionarily-conserved BRC repeats, which individually engage RAD51 via the motif Phe-x-x-Ala. Using structure-guided molecular design, templated on a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13c1c19577aace398628cc240fb87a89
https://doi.org/10.1101/2020.07.15.200709
https://doi.org/10.1101/2020.07.15.200709
Autor:
Bryn Hardwick, Juan A. Bernal, Dirk Gewert, Joaquin A. Palma, Cristina Sánchez-Ramos, Francisco Cruz, David Sanz-Rosa, Andrés González-Guerra, Borja Ibanez, Grahame J. McKenzie, Vicente Andrés, Marta Roche-Molina
Publikováno v:
Repisalud
Instituto de Salud Carlos III (ISCIII)
ABACUS. Repositorio de Producción Científica
Universidad Europea (UEM)
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Instituto de Salud Carlos III (ISCIII)
ABACUS. Repositorio de Producción Científica
Universidad Europea (UEM)
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
N-methyl-2-pyrrolidone (NMP) is a versatile water-miscible polar aprotic solvent. It is used as a drug solubilizer and penetration enhancer in human and animal, yet its bioactivity properties remain elusive. Here, we report that NMP is a bioactive an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b2dd2b20515f3a57a82e5c67ad9bce
https://hdl.handle.net/20.500.12105/11097
https://hdl.handle.net/20.500.12105/11097
Autor:
Vikrant Kumar, Bryn Hardwick, Saranya Giridharan, Sneha Sudhakar, Markus Muellner, Manjunath A. Hurakadli, Ashok R. Venkitaraman, Gayathri Sadasivam, T.K. Prasad, Neelagandan Kamariah, Grahame J. McKenzie, Alex T. Crooks, Subashini Mathivanan, Paul M. Watt, Miguel Coelho, Sneha Bairy, Nadia Milech, Chandan Mithra, Christopher J. Torrance, Amy Emery, Kavitha Bharatham
Publikováno v:
Cell Chemical Biology
Summary Genetic screening technologies to identify and validate macromolecular interactions (MMIs) essential for complex pathways remain an important unmet need for systems biology and therapeutics development. Here, we use a library of peptides from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82261f81e78bea18e12f385b6c100941
https://doi.org/10.1016/j.chembiol.2021.05.009
https://doi.org/10.1016/j.chembiol.2021.05.009
Autor:
Pooja Sharma, Marko Hyvönen, Robert Mahen, Bryn Hardwick, David J. Huggins, David R. Spring, Ashok R. Venkitaraman, M. Rossmann, Jamie E. Stokes, Amy Emery, D.L. Kunciw, Grahame J. McKenzie
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
The human polo-like kinase PLK1 coordinates mitotic chromosome segregation by phosphorylating multiple chromatin- and kinetochore-binding proteins. How PLK1 activity is directed to specific substrates via phosphopeptide recognition by its carboxyl-te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae35f160ed3a220ca50570e2ae438818
https://www.repository.cam.ac.uk/handle/1810/312387
https://www.repository.cam.ac.uk/handle/1810/312387
Autor:
Ana J. Narvaez, Meredith Roberts-Thomson, Richard J. Boyce, Suzan Ber, Christopher J. Torrance, Alex T. Crooks, Robert George Boyle, Grahame J. McKenzie, David Perera, Samuel P. Barker, Estrella Guarino Almeida, Ian A. Prior, Bryn Hardwick, David J. Huggins, Ashok R. Venkitaraman, David W. Walker, Fiona E. Hood, Roberta Azzarelli, Amy Emery
Publikováno v:
Cell Chemical Biology
Summary Mutations activating KRAS underlie many forms of cancer, but are refractory to therapeutic targeting. Here, we develop Poloppin, an inhibitor of protein-protein interactions via the Polo-box domain (PBD) of the mitotic Polo-like kinases (PLKs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52f2f37f22ae1cd96be9703289bb40c
http://hdl.handle.net/11568/1013971
http://hdl.handle.net/11568/1013971
Autor:
Grahame J. McKenzie, David R. Spring, Niklas Sköld, Yu Heng Lau, Ashok R. Venkitaraman, David P. Lane, Chandra S. Verma, Peterson de Andrade
Publikováno v:
Org. Biomol. Chem.. 12:4074-4077
Stapling peptides for inhibiting the p53/MDM2 interaction is a promising strategy for developing anti-cancer therapeutic leads. We evaluate double-click stapled peptides formed from p53-based diazidopeptides with different staple positions and azido
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5054ba601f001b35bc83610ec8025879
https://doi.org/10.1039/c4ob00742e
https://doi.org/10.1039/c4ob00742e
Autor:
Matej, Janeček, Maxim, Rossmann, Pooja, Sharma, Amy, Emery, David J, Huggins, Simon R, Stockwell, Jamie E, Stokes, Yaw S, Tan, Estrella Guarino, Almeida, Bryn, Hardwick, Ana J, Narvaez, Marko, Hyvönen, David R, Spring, Grahame J, McKenzie, Ashok R, Venkitaraman
Publikováno v:
Scientific Reports
The essential mitotic kinase Aurora A (AURKA) is controlled during cell cycle progression via two distinct mechanisms. Following activation loop autophosphorylation early in mitosis when it localizes to centrosomes, AURKA is allosterically activated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ced2b9849064fa8624d123cd796d9bce
https://pubmed.ncbi.nlm.nih.gov/27339427
https://pubmed.ncbi.nlm.nih.gov/27339427
Autor:
Yong Qing Yang, Steffen Lang, Paweł Śledź, Marko Hyvönen, Ashok R. Venkitaraman, Christopher D. Stubbs, Grahame J. McKenzie, Chris Abell
Publikováno v:
Angewandte Chemie (International Ed. in English)
Protein–protein interactions are notoriously difficult to target with small molecules as large, discontinuous surfaces are often involved1, 2 that can adopt different conformations to interact with diverse binding partners.3–5 In addition, protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6237e556657b3a6369ddda8c6131b57a
http://europepmc.org/articles/PMC3555362
http://europepmc.org/articles/PMC3555362