Zobrazeno 1 - 10
of 460
pro vyhledávání: '"Grahame Hardie"'
Autor:
Said, Esraa A., Lewis, Ryan W., Dallas, Mark L., Peers, Chris, Ross, Fiona A., Unciti-Broceta, Asier, Grahame Hardie, D., Mark Evans, A.
Publikováno v:
In Biochemical Pharmacology December 2024 230 Part 1
Autor:
Daniel M. Virga, Stevie Hamilton, Bertha Osei, Abigail Morgan, Parker Kneis, Emiliano Zamponi, Natalie J. Park, Victoria L. Hewitt, David Zhang, Kevin C. Gonzalez, Fiona M. Russell, D. Grahame Hardie, Julien Prudent, Erik Bloss, Attila Losonczy, Franck Polleux, Tommy L. Lewis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Neuronal mitochondria play important roles beyond ATP generation, including Ca2+ uptake, and therefore have instructive roles in synaptic function and neuronal response properties. Mitochondrial morphology differs significantly between the a
Externí odkaz:
https://doaj.org/article/4622b875797a4a148a830a6b459942d0
Autor:
Sandy MacMillan, Andrew P. Holmes, Mark L. Dallas, Amira D. Mahmoud, Michael J. Shipston, Chris Peers, D. Grahame Hardie, Prem Kumar, A. Mark Evans
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Unlike AMPK, Liver kinase B1 (LBK1) is required for carotid body chemosensing and the hypoxic ventilatory response. Moreover, loss of LBK1, but not AMPK, provokes Cheyne-Stokes-like breathing during hypoxia, which is associated with heart failure.
Externí odkaz:
https://doaj.org/article/b2f40950c892468d9001b1c437412b1e
Autor:
Anees Rahman Cheratta, Faisal Thayyullathil, Simon A. Hawley, Fiona A. Ross, Abdelmajdid Atrih, Douglas J. Lamont, Siraj Pallichankandy, Karthikeyan Subburayan, Ameer Alakkal, Rachid Rezgui, Alex Gray, D. Grahame Hardie, Sehamuddin Galadari
Publikováno v:
Cell Reports, Vol 39, Iss 5, Pp 110761- (2022)
Summary: AMP-activated protein kinase (AMPK) coordinates energy homeostasis during metabolic and energy stress. We report that the catalytic subunit isoform AMPK-α1 (but not α2) is cleaved by caspase-3 at an early stage during induction of apoptosi
Externí odkaz:
https://doaj.org/article/dc89a458593d474787f73e8f3cb61c58
Akademický článek
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Autor:
Sandy MacMillan, Andrew P. Holmes, Mark L. Dallas, Amira D. Mahmoud, Michael J. Shipston, Chris Peers, D. Grahame Hardie, Prem Kumar, A. Mark Evans
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/13d010bbbbb043198eb9f05b25e647fe
Autor:
Grahame Hardie
Publikováno v:
Biochemical Journal. 479:2327-2343
A casual decision made one evening in 1976, in a bar near the Biochemistry Department at the University of Dundee, led me to start my personal research journey by following up a paper that suggested that acetyl-CoA carboxylase (ACC) (believed to be a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b5db06b5c71851afa3b60b9d99ce16
https://doi.org/10.1042/bcj20220255
https://doi.org/10.1042/bcj20220255
Publikováno v:
Open Biology, Vol 9, Iss 7 (2019)
The AMP-activated protein kinase (AMPK) acts as a cellular energy sensor. Once switched on by increases in cellular AMP : ATP ratios, it acts to restore energy homeostasis by switching on catabolic pathways while switching off cell growth and prolife
Externí odkaz:
https://doaj.org/article/80c9c9190be44145b1fbeda335455d0c
Autor:
Diana Vara-Ciruelos, Madhumita Dandapani, Fiona M. Russell, Katarzyna M. Grzes, Abdelmadjid Atrih, Marc Foretz, Benoit Viollet, Douglas J. Lamont, Doreen A. Cantrell, D. Grahame Hardie
Publikováno v:
Cell Reports, Vol 27, Iss 3, Pp 690-698.e4 (2019)
Summary: AMPK acts downstream of the tumor suppressor LKB1, yet its role in cancer has been controversial. AMPK is activated by biguanides, such as metformin and phenformin, and metformin use in diabetics has been associated with reduced cancer risk.
Externí odkaz:
https://doaj.org/article/db8d81d633214b928b39b3ad83b03e1d