Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Graham Warrellow"'
Autor:
Graham Warrellow
Publikováno v:
Future Medicinal Chemistry. 4:1047-1051
Following his academic studies at the University of Surrey (UK), Graham Warrellow entered the pharmaceutical industry to pursue a career at the forefront of drug discovery. Following successful spells at Wyeth, Celltech and Almirall, he joined UCB as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dce7c42323adfec5e60365a51b888841
https://doi.org/10.4155/fmc.12.54
https://doi.org/10.4155/fmc.12.54
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3605-3608
The preparation of the sulfoxide analogues 7, 8, and 9 and their enantiomerically pure forms is discussed as well as their ability to act as prodrugs of the potent and selective sulfone-containing COX-2 inhibitors 1, 2, and 3. Sulfoxide derivatives 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b876e6fbb26321f1b86a8f3fc2c379a
https://doi.org/10.1016/j.bmcl.2006.03.101
https://doi.org/10.1016/j.bmcl.2006.03.101
Autor:
Carles Puig, Jordi Gras, Elena Calaf, Arantxa Cardús, Lluís Pagès, Jorge Beleta, Montse Miralpeix, Francisca Antón, Graham Warrellow, Hamish Ryder, José Prieto, Alvaro Cardenas, Mònica Aparici, Silvia Fonquerna, Josep M. Huerta, Dolors Vilella
Publikováno v:
Journal of Medicinal Chemistry. 47:6326-6337
A series of indolylpiperidinyl derivatives were prepared and evaluated for their activity as histamine H(1) antagonists. Structure-activity relationship studies were directed toward improving in vivo activity and pharmacokinetic profile of our first
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f2efad3e23777d79ac1bd1d2cbd9dd
https://doi.org/10.1021/jm0498203
https://doi.org/10.1021/jm0498203
Autor:
Dolors Vilella, Silvia Fonquerna, Hamish Ryder, Lluís Pagès, Jorge Beleta, Montse Miralpeix, José Prieto, Arantxa Cardús, Graham Warrellow, Carles Puig, Francisca Antón, Mònica Aparici
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:1165-1167
The synthesis and structure–activity relationships of piperidinylpyrrolopyridines as potent and selective H1 antagonists are discussed. It was found that the nature of the acid chain bonded to piperidine was a key feature for maintaining both the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086b180aebe7d95dcea12ca173e16c39
https://doi.org/10.1016/j.bmcl.2004.12.008
https://doi.org/10.1016/j.bmcl.2004.12.008
Autor:
Bernat Vidal, Arsenio Nueda, María Isabel Cadavid, Cristina Esteve, Alvaro Cardenas, María Isabel Loza, Nuria Godessart, Rosa López, Marta Calbet, Mercè Pont, Graham Warrellow, Jorge Beleta, Hamish Ryder, T. Domenech, Raquel F. Reinoso, Sonia Benito
Publikováno v:
Journal of medicinal chemistry. 50(11)
A novel series of N-heteroaryl 4‘-(2-furyl)-4,5‘-bipyrimidin-2‘-amines has been identified as potent and selective A2B adenosine receptor antagonists. In particular, compound 5 showed high affinity for the A2B receptor (Ki = 17 nM), good select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a05154e5d49864031bef2da5ee19a9f2
https://pubmed.ncbi.nlm.nih.gov/17469811
https://pubmed.ncbi.nlm.nih.gov/17469811
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(12)
The preparation of the sulfoxide analogues 2 and 4, and their enantiomeric pure forms is discussed as well as their potential to act as prodrugs to the potent and selective sulfone-containing COX-2 inhibitors rofecoxib and etoricoxib. Sulfoxides 2 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec308c0d0e00fb2aeebbda5679cd7dc
https://pubmed.ncbi.nlm.nih.gov/16616494
https://pubmed.ncbi.nlm.nih.gov/16616494
Publikováno v:
DRUG DISCOVERY TODAY. 2(3)
Phosphodiesterase 4 (PDE 4) enzymes are the principal phosphodiesterases responsible for the hydrolysis of cAMP in pro-inflammatory leukocytes. The functional consequences of elevating cAMP in these cells suggests that inhibition of PDE 4 offers a no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05f9e96e38e13c5fb427f7e593af21c2
http://ora.ox.ac.uk/objects/uuid:e80b9f4c-43a1-430f-8244-44d68ddd2af8
http://ora.ox.ac.uk/objects/uuid:e80b9f4c-43a1-430f-8244-44d68ddd2af8
Autor:
Bernat Vidal, Arsenio Nueda, Cristina Esteve, Teresa Domenech, Sonia Benito, Raquel F. Reinoso, Mercè Pont, Marta Calbet, Rosa López, María Isabel Cadavid, María Isabel Loza, Álvaro Cárdenas, Núria Godessart, Jorge Beleta, Graham Warrellow, Hamish Ryder
Publikováno v:
Journal of Medicinal Chemistry; May2007, Vol. 50 Issue 11, p2732-2736, 5p
Publikováno v:
Journal of medicinal chemistry. 32(1)
A series of disulfonamidobenzo[a]quinolizines were synthesized and evaluated for their alpha 2- and alpha 1-adrenoceptor antagonist activity on the rat vas deferens and anococcygeus muscle, respectively. N-((2 beta,11b alpha)-1,3,4,6,7,11b-Hexahydro-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42596d56e2cc16ee25fd9769896bf2a9
https://pubmed.ncbi.nlm.nih.gov/2562854
https://pubmed.ncbi.nlm.nih.gov/2562854