Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Graham W. Heberlig"'
Publikováno v:
Molecules, Vol 22, Iss 5, p 707 (2017)
Bacterial polyketides are highly biologically active molecules that are frequently used as drugs, particularly as antibiotics and anticancer agents, thus the discovery of new polyketides is of major interest. Since the 1980s discovery of polyketides
Externí odkaz:
https://doaj.org/article/eaf5a21028ad430a8b32b15b79891694
Publikováno v:
Journal of Natural Products. 83:1990-1997
Cereulide is a toxic cyclic depsidodecapeptide produced in Bacillus cereus by two nonribosomal peptide synthetases, CesA and CesB. While highly similar in structure to valinomycin and with a homolo...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c88bf60a6a25ffdd5cf2723f4484a43
https://doi.org/10.1021/acs.jnatprod.0c00333
https://doi.org/10.1021/acs.jnatprod.0c00333
Autor:
Sam Shields, Mike G. Darnowski, Myron L. Smith, David P. Overy, Graham W. Heberlig, Thomas E. Witte, Anatoly A Belov, Amanda Sproule, Christopher N. Boddy
Publikováno v:
Fungal Genetics and Biology. 157:103633
Vegetative incompatibility (VI) is a form of non-self allorecognition in filamentous fungi that restricts conspecific hyphal fusion and the formation of heterokaryons. In the chestnut pathogenic fungus, Cryphonectria parasitica, VI is controlled by s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b34dde6f15e0d672b7ee5e2d32640c
https://doi.org/10.1016/j.fgb.2021.103633
https://doi.org/10.1016/j.fgb.2021.103633
Autor:
Jason W. Chin, Mohan Mahesh, Graham W. Heberlig, T.M. Schmeing, Christopher N. Boddy, Nicolas Huguenin-Dezot, D.P. Nguyen, Mark H. Dornan, D.A. Alonzo
Publikováno v:
Nature. 565(7737)
Many enzymes catalyse reactions that proceed through covalent acyl-enzyme (ester or thioester) intermediates1. These enzymes include serine hydrolases2,3 (encoded by one per cent of human genes, and including serine proteases and thioesterases), cyst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bbea4bfd4d9e8440fa77111fb3d197b
https://pubmed.ncbi.nlm.nih.gov/30814698
https://pubmed.ncbi.nlm.nih.gov/30814698
Autor:
Graham W. Heberlig, Meng Wang, Leah Susser, Ryan D. Simard, Christopher N. Boddy, Jesse T C Brown, Monica Wirz, Mark Horsman, Wei Zhang
Publikováno v:
Organicbiomolecular chemistry. 16(32)
A key missing tool in the chemist's toolbox is an effective biocatalyst for macrocyclization. Macrocycles limit the conformational flexibility of small molecules, often improving their ability to bind selectively and with high affinity to a target, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709d5a236418f01f4f6ef12bab83c890
https://pubmed.ncbi.nlm.nih.gov/30052255
https://pubmed.ncbi.nlm.nih.gov/30052255
Publikováno v:
International journal of biological macromolecules. 83
In order to diversify the number of applications for poly[(R)-3-hydroxyalkanoates] (PHAs), methods must be developed to alter their physical properties so they are not limited to aliphatic polyesters. Recently we developed Escherichia coli LSBJ as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb6c1b764a3b1bb360a1c2b84bdbac9
https://pubmed.ncbi.nlm.nih.gov/26616449
https://pubmed.ncbi.nlm.nih.gov/26616449
Publikováno v:
Molecules, Vol 22, Iss 5, p 707 (2017)
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Bacterial polyketides are highly biologically active molecules that are frequently used as drugs, particularly as antibiotics and anticancer agents, thus the discovery of new polyketides is of major interest. Since the 1980s discovery of polyketides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135b22a19f3508ccfb2987db4732c08c
https://doi.org/10.3390/molecules22050707
https://doi.org/10.3390/molecules22050707