Zobrazeno 1 - 10 of 33 pro vyhledávání: '"Graham W, Neill"'
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Supplementary:Figure Legend from A Novel Mechanism for Activation of GLI1 by Nuclear SMO That Escapes Anti-SMO Inhibitors
Autor: Graham W. Neill, Mike P. Philpott, Kenneth J. Linton, David P. Kelsell, Ravinder Atkar, Muhammad S. Pirzado, Catherine A. Harwood, Dimalee S. Herath, Joanne L. Selway, Allon Hazan, Muhammad M. Rahman
[A] Various exon 24 clones generated from heterogeneous populations of PTCH1 suppressed NEB1 cells show reduced PTCH1 and increased GLI1 mRNA expression. [B] Both human and mouse SMO protein sequences contain predicted nuclear and nucleolar localisat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b044d18f7b24f0f78ee05c491128fa
https://doi.org/10.1158/0008-5472.22420313
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2
Data from A Novel Mechanism for Activation of GLI1 by Nuclear SMO That Escapes Anti-SMO Inhibitors
Autor: Graham W. Neill, Mike P. Philpott, Kenneth J. Linton, David P. Kelsell, Ravinder Atkar, Muhammad S. Pirzado, Catherine A. Harwood, Dimalee S. Herath, Joanne L. Selway, Allon Hazan, Muhammad M. Rahman
Small-molecule inhibitors of the Hedgehog (HH) pathway receptor Smoothened (SMO) have been effective in treating some patients with basal cell carcinoma (BCC), where the HH pathway is often activated, but many patients respond poorly. In this study,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::843ce48a60ee1307e6d00253da450b72
https://doi.org/10.1158/0008-5472.c.6510620
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4
Data from αvβ6 Integrin Promotes the Invasion of Morphoeic Basal Cell Carcinoma through Stromal Modulation
Autor: Gareth J. Thomas, Ian R. Hart, John F. Marshall, Graham W. Neill, Sarah Dickinson, Daniel Marsh
Basal cell carcinoma (BCC) is the most prevalent cancer in the Western world and its incidence is increasing. The pathogenesis of BCC involves deregulated Sonic hedgehog signaling, leading to activation of the Gli transcription factors. Most BCCs hav
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1554442366a9c663679adf4416649273
https://doi.org/10.1158/0008-5472.c.6497742
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5
Data from Activation of the BCL2 Promoter in Response to Hedgehog/GLI Signal Transduction Is Predominantly Mediated by GLI2
Autor: Fritz Aberger, Anna-Maria Frischauf, Cornelia Hauser-Kronberger, Harald Esterbauer, Michael P. Philpott, Graham W. Neill, Thomas Eichberger, Harald Schnidar, Maria Kasper, Gerhard Regl
Aberrant activation of the Hedgehog (HH)/GLI signaling pathway has been implicated in the development of basal cell carcinoma (BCC). The zinc finger transcription factors GLI1 and GLI2 are considered mediators of the HH signal in epidermal cells, alt
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e0f176b397fe87c15a0214168f39918
https://doi.org/10.1158/0008-5472.c.6493830.v1
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