Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Graham V. Williams"'
Autor:
Rouba Kozak, Tamás Kiss, Keith Dlugolenski, David E. Johnson, Roxanne R. Gorczyca, Kyle Kuszpit, Brian D. Harvey, Polina Stolyar, Stacey J. Sukoff Rizzo, William E. Hoffmann, Dmitri Volfson, Mihaly Hajós, Jennifer E. Davoren, Amanda L. Abbott, Graham V. Williams, Stacy A. Castner, David L. Gray
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Selective activation of dopamine D1 receptors remains a promising pro-cognitive therapeutic strategy awaiting robust clinical investigation. PF-6142 is a key example from a recently disclosed novel series of non-catechol agonists and partial agonists
Externí odkaz:
https://doaj.org/article/0f0c6a051bdf46babdb1a3b0bfe553ab
Autor:
Stacy A. Castner, Linli Zhang, Charles R. Yang, Junliang Hao, Jeffrey W. Cramer, Xushan Wang, Robert F. Bruns, Hugh Marston, Kjell A. Svensson, Graham V. Williams
Publikováno v:
Psychopharmacology. 240:1033-1048
Rationale Dopamine (DA) signaling through the D1 receptor has been shown to be integral to multiple aspects of cognition, including the core process of working memory. The discovery of positive allosteric modulators (PAMs) of the D1 receptor has enab
Autor:
Xiaotian T. Fang, Jim Ropchan, Amy F.T. Arnsten, Graham V. Williams, Soheila Najafzadeh, Ming-Qiang Zheng, Richard E. Carson, Tamas L. Horvath, Daniel Holden, Stacy A. Castner
Publikováno v:
Alzheimer's & Dementia. 16
Autor:
Graham V. Williams, Jennifer E. Davoren, Dmitri Volfson, David Gray, Mihály Hajós, Kyle Kuszpit, Tamás Kiss, William E. Hoffmann, Brian D. Harvey, Roxanne R Gorczyca, Stacey J. Sukoff Rizzo, David E. Johnson, Amanda L. Abbott, Keith Dlugolenski, Stacy A. Castner, Polina Stolyar, Rouba Kozak
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Frontiers in Pharmacology
Frontiers in Pharmacology
Selective activation of dopamine D1 receptors remains a promising pro-cognitive therapeutic strategy awaiting robust clinical investigation. PF-6142 is a key example from a recently disclosed novel series of non-catechol agonists and partial agonists
Autor:
Amy B. Dounay, Kari R. Fonseca, Graham V. Williams, Christine A. Strick, Douglas S. Chapin, Mihály Hajós, Amanda L. Abbott, Damon Young, William E. Hoffmann, Dina McGinnis, Weldon Horner, Tamás Kiss, Brooke M. Roberts, Rouba Kozak, Victor Guanowsky, Patricia A. Seymour, Brian M. Campbell, Stacy A. Castner
Publikováno v:
Journal of Neuroscience. 34:10592-10602
The elevation of kynurenic acid (KYNA) observed in schizophrenic patients may contribute to core symptoms arising from glutamate hypofunction, including cognitive impairments. Although increased KYNA levels reduce excitatory neurotransmission, KYNA h
Autor:
Krista Fowles, Eugenii A. Rabiner, Kelly P. Cosgrove, Graham V. Williams, Tim Mulnix, Xiao Jin, Jim Ropchan, Yiyun Huang, David Labaree, Richard E. Carson, Christine M. Sandiego, Stacy A. Castner, Lisa Wells
Publikováno v:
Journal of Nuclear Medicine. 54:1962-1968
Neuroreceptor imaging in the nonhuman primate (NHP) is valuable for translational research approaches in humans. However, most NHP studies are conducted under anesthesia, which affects the interpretability of receptor binding measures. The aims of th
Autor:
Jeffrey S. Smith, Graham V. Williams, Timothy Piser, Yi Wang, Gennady N. Smagin, Ladislav Mrzljak, Stacy A. Castner, Edward P. Christian
Publikováno v:
Biological Psychiatry. 69:12-18
Background Nicotine improves cognition in humans and animal models of neuropsychiatric disorders. Here, we sought to establish whether selective stimulation of the neuronal nicotinic α7 receptor could improve spatial working memory in nonhuman prima
Autor:
Patricia A. Seymour, Christopher L. Shaffer, Brooke M. Roberts, Graham V. Williams, Christopher J. Schmidt, Stacy A. Castner
Publikováno v:
NeuroReport. 21:390-394
Glycine transporter inhibitors have recently been reported to improve symptoms in patients with schizophrenia. Here we used acute ketamine in the nonhuman primate to test the effectiveness of the novel glycine transporter inhibitor, PF-3463275, in a
Autor:
Gerard Sanacora, John H. Krystal, Ralph E. Hoffman, David F. Tolin, Stacy A. Castner, Deane E. Aikins, D. Cyril D’Souza, Graham V. Williams
Publikováno v:
Drug Discovery Today. 14:690-697
Current treatments for psychiatric disorders were developed with the aim of providing symptomatic relief rather than reversing underlying abnormalities in neuroplasticity or neurodevelopment that might contribute to psychiatric disorders. This review
Autor:
Graham V. Williams, Stacy A. Castner
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 31:1572-1592
Repeated, intermittent administration of psychomotor stimulants, or D1 agonists in dopamine-deficient states, induces behavioral sensitization, characterized by an enhanced response to a subsequent acute low dose challenge, which may be manifested in