Výsledky vyhledávání - "Graham T, Dempsey"

Akademický článek

Developing antisense oligonucleotides for a TECPR2 mutation-induced, ultra-rare neurological disorder using patient-derived cellular models

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 189-203 (2022)

Mutations in the TECPR2 gene are the cause of an ultra-rare neurological disorder characterized by intellectual disability, impaired speech, motor delay, and hypotonia evolving to spasticity, central sleep apnea, and premature death (SPG49 or HSAN9;

Externí odkaz: https://doaj.org/article/555fd4156baf47509e8e7211947eb238

Zobrazit plný text záznamu

Akademický článek

Highly Parallelized, Multicolor Optogenetic Recordings of Cellular Activity for Therapeutic Discovery Applications in Ion Channels and Disease-Associated Excitable Cells

Autor: Gabriel B. Borja, Hongkang Zhang, Benjamin N. Harwood, Jane Jacques, Jennifer Grooms, Romina O. Chantre, Dawei Zhang, Adam Barnett, Christopher A. Werley, Yang Lu, Steven F. Nagle, Owen B. McManus, Graham T. Dempsey

Publikováno v: Frontiers in Molecular Neuroscience, Vol 15 (2022)

Optogenetic assays provide a flexible, scalable, and information rich approach to probe compound effects for ion channel drug targets in both heterologous expression systems and associated disease relevant cell types. Despite the potential utility an

Externí odkaz: https://doaj.org/article/fbccbcbdfa4349c68b6c7eb8e5f3089d

Zobrazit plný text záznamu

'Channeling' therapeutic discovery for epileptic encephalopathy through iPSC technologies

Autor: Dina Simkin, Christina Ambrosi, Kelly A. Marshall, Luis A. Williams, Jordyn Eisenberg, Mennat Gharib, Graham T. Dempsey, Alfred L. George, Owen B. McManus, Evangelos Kiskinis

Publikováno v: Trends Pharmacol Sci

Induced pluripotent stem cell (iPSC) and gene editing technologies have revolutionized the field of in vitro disease modeling, granting us access to disease-pertinent human cells of the central nervous system. These technologies are particularly well

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30dfd020322e7bbc3d826e842e56c497
https://europepmc.org/articles/PMC9119009/

Zobrazit plný text záznamu

Correlation of Optical and Automated Patch Clamp Electrophysiology for Identification of NaV1.7 Inhibitors

Autor: Owen B. McManus, Vivian Hecht, Violeta Yu, Chris M Hempel, Graham T. Dempsey, Ryan J. Babcock, Michael Jarosh, Joseph G. McGivern, Hongkang Zhang, Kevin Dong, Bryan D. Moyer, Christopher A. Werley

Publikováno v: SLAS Discovery. 25:434-446

The voltage-gated sodium channel Nav1.7 is a genetically validated target for pain; pharmacological blockers are promising as a new class of nonaddictive therapeutics. The search for Nav1.7 subtype selective inhibitors requires a reliable, scalable,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b158bb79b66d537a5d39c6d8bdd18fe7
https://doi.org/10.1177/2472555220914532

Zobrazit plný text záznamu

Suppression of Kv3.3 channels by antisense oligonucleotides reverses biochemical effects and motor impairment in spinocerebellar ataxia type 13 mice

Autor: Owen B. McManus, Yalan Zhang, Leonard K. Kaczmarek, Heather McClure, David J. Gerber, Imran H. Quraishi, Siddharth Kale, Luis A. Williams, Sudhir Agrawal, Graham T. Dempsey, Yung-Chih Cheng

Publikováno v: FASEB J

Mutations in KCNC3, the gene that encodes the Kv3.3 voltage dependent potassium channel, cause Spinocerebellar Ataxia type 13 (SCA13), a disease associated with disrupted motor behaviors, progressive cerebellar degeneration, and abnormal auditory pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e2e9d9ea8e5f1ef52b0be029bc7458
https://pubmed.ncbi.nlm.nih.gov/34820911

Zobrazit plný text záznamu

Probing Synaptic Signaling with Optogenetic Stimulation and Genetically Encoded Calcium Reporters

Autor: Gabriel B, Borja, Himali, Shroff, Hansini, Upadhyay, Pin W, Liu, Valeriya, Baru, Yung-Chih, Cheng, Owen B, McManus, Luis A, Williams, Graham T, Dempsey, Christopher A, Werley

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2191

Optogenetics provides a powerful approach for investigating neuronal electrophysiology at the scale required for drug discovery applications. Probing synaptic function with high throughput using optogenetics requires robust tools that enable both pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a8060881a314c8e3cd5a056924005c70
https://pubmed.ncbi.nlm.nih.gov/32865742

Zobrazit plný text záznamu