Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Graham Su"'
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 19, Iss 2, Pp 191-207 (2021)
The successes with immune checkpoint blockade (ICB) and chimeric antigen receptor (CAR)-T-cell therapy in treating multiple cancer types have established immunotherapy as a powerful curative option for patients with advanced cancers. Unfortunately, m
Externí odkaz:
https://doaj.org/article/e7e7c7dbc16e406b86036798eb30d031
Autor:
Yong Xiao, Zhen Wang, Mengjie Zhao, Yanxiang Deng, Mingyu Yang, Graham Su, Kun Yang, Chunfa Qian, Xinhua Hu, Yong Liu, Liangyuan Geng, Yang Xiao, Yuanjie Zou, Xianglong Tang, Hongyi Liu, Hong Xiao, Rong Fan
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Human glioblastoma (GBM), the most aggressive brain tumor, comprises six major subtypes of malignant cells, giving rise to both inter-patient and intra-tumor heterogeneity. The interaction between different tumor subtypes and non-malignant cells to c
Externí odkaz:
https://doaj.org/article/1be535c10e8341ee88a744e8e0c98020
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100532- (2021)
Summary: This protocol describes the use of the deterministic barcoding in tissue for spatial omics sequencing platform to construct a multi-omics atlas on fixed frozen tissue samples. This approach uses a microfluidic-based method to introduce combi
Externí odkaz:
https://doaj.org/article/79da161005a1401593507c2719da7955
Autor:
Di Zhang, Yanxiang Deng, Petra Kukanja, Eneritz Agirre, Marek Bartosovic, Mingze Dong, Cong Ma, Sai Ma, Graham Su, Shuozhen Bao, Yang Liu, Yang Xiao, Gorazd B. Rosoklija, Andrew J. Dwork, J. John Mann, Kam W. Leong, Maura Boldrini, Liya Wang, Maximilian Haeussler, Benjamin J. Raphael, Yuval Kluger, Gonçalo Castelo-Branco, Rong Fan
Publikováno v:
Nature. 616:113-122
Emerging spatial technologies, including spatial transcriptomics and spatial epigenomics, are becoming powerful tools for profiling of cellular states in the tissue context1–5. However, current methods capture only one layer of omics information at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92a282f49777c7581b07c8f415de49f0
https://doi.org/10.1038/s41586-023-05795-1
https://doi.org/10.1038/s41586-023-05795-1
Autor:
Yang Liu, Marcello DiStasio, Graham Su, Hiromitsu Asashima, Archibald Enninful, Xiaoyu Qin, Yanxiang Deng, Jungmin Nam, Fu Gao, Pino Bordignon, Marco Cassano, Mary Tomayko, Mina Xu, Stephanie Halene, Joseph E. Craft, David Hafler, Rong Fan
Publikováno v:
Nature Biotechnology.
In this study, we extended co-indexing of transcriptomes and epitopes (CITE) to the spatial dimension and demonstrated high-plex protein and whole transcriptome co-mapping. We profiled 189 proteins and whole transcriptome in multiple mouse tissue typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fab023d8c51baf7be3f7cc4a2c696b38
https://doi.org/10.1038/s41587-023-01676-0
https://doi.org/10.1038/s41587-023-01676-0
Autor:
Graham Su
This protocol describes the use of Deterministic Barcoding in Tissue for spatial omics sequencing (DBiT-seq) platform to construct a multi-omics atlas on fixed frozen tissue samples. This approach uses a microfluidic-based method to introduce combina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7313c2c668689921a513560a32510a44
https://doi.org/10.17504/protocols.io.3byl4j2kolo5/v1
https://doi.org/10.17504/protocols.io.3byl4j2kolo5/v1
Autor:
Rong Fan, Di Zhang, Yanxiang Deng, Petra Kukanja, Marek Bartosovic, Graham Su, Shuozhen Bao, Yang Liu, Yang Xiao, Sai Ma, Gorazd Rosoklija, Andrew Dowrk, J. Mann, Kam Leong, Maura Boldrini, Goncalo Castelo-Branco
Emerging spatial technologies including spatial transcriptomics and spatial epigenomics are becoming powerful tools for profiling cellular states in the tissue context. However, current methods capture only one layer of omics information at a time pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4a4f76501f67669de9aba847e48186a
https://doi.org/10.21203/rs.3.rs-1728747/v1
https://doi.org/10.21203/rs.3.rs-1728747/v1
Publikováno v:
Genomics, Proteomics & Bioinformatics
Genomics, Proteomics & Bioinformatics, Vol 19, Iss 2, Pp 191-207 (2021)
Genomics, Proteomics & Bioinformatics, Vol 19, Iss 2, Pp 191-207 (2021)
The successes with immune checkpoint blockade (ICB) and chimeric antigen receptor (CAR)-T-cell therapy in treating multiple cancer types have established immunotherapy as a powerful curative option for patients with advanced cancers. Unfortunately, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e48c030d894e6fc559b4301e24b405e
http://europepmc.org/articles/PMC8602396
http://europepmc.org/articles/PMC8602396
Autor:
Rong Fan, Yang Liu, Marcello DiStasio, Graham Su, Hiromitsu Asashima, Archibald Enninful, Xiaoyu Qin, Yanxiang Deng, Pino Bordignon, Marco Cassano, Mary Tomayko, Mina Xu, Stephanie Halene, Joseph Craft, David Hafler
We present spatial-CITE-seq for high-plex protein and whole transcriptome co-mapping, which was firstly demonstrated for profiling 198 proteins and transcriptome in multiple mouse tissue types. It was then applied to human tissues to measure 283 prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a52fabe2fe644f1e1191c383cec09bda
https://doi.org/10.21203/rs.3.rs-1499315/v1
https://doi.org/10.21203/rs.3.rs-1499315/v1
Autor:
Yanxiang Deng, Marek Bartosovic, Petra Kukanja, Di Zhang, Yang Liu, Graham Su, Archibald Enninful, Zhiliang Bai, Gonçalo Castelo-Branco, Rong Fan
Publikováno v:
Science
Spatial omics emerged as a new frontier of biological and biomedical research. Here, we present spatial-CUT&Tag for spatially resolved genome-wide profiling of histone modifications by combining in situ CUT&Tag chemistry, microfluidic deterministic b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5e3fd5468ec4293b6aaff8e4f049a9b
https://europepmc.org/articles/PMC7612972/
https://europepmc.org/articles/PMC7612972/