Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Graham Sproat"'
Autor:
Simon T. Barry, Stephen R. Wedge, Masabumi Shibuya, Juliane M. Jürgensmeier, Donald J. Ogilvie, Laurent Hennequin, Charles L. Farnsworth, Jeffrey C. Silva, Claire Barnes, Sian Taylor, Graham Sproat, Nicola Broadbent, Philippa Dudley, Jane Kendrew, Anna Wainwright, Sue Ashton, Neil H. James, Zena Wilson, Kirsty Ratcliffe, Sandra R. Brave
Supplementary Tables 1-3 from Assessing the Activity of Cediranib, a VEGFR-2/3 Tyrosine Kinase Inhibitor, against VEGFR-1 and Members of the Structurally Related PDGFR Family
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b81f7c3e475189f7807aec38b527252
https://doi.org/10.1158/1535-7163.22496458.v1
https://doi.org/10.1158/1535-7163.22496458.v1
Autor:
Simon T. Barry, Stephen R. Wedge, Masabumi Shibuya, Juliane M. Jürgensmeier, Donald J. Ogilvie, Laurent Hennequin, Charles L. Farnsworth, Jeffrey C. Silva, Claire Barnes, Sian Taylor, Graham Sproat, Nicola Broadbent, Philippa Dudley, Jane Kendrew, Anna Wainwright, Sue Ashton, Neil H. James, Zena Wilson, Kirsty Ratcliffe, Sandra R. Brave
Supplementary Figure 1 from Assessing the Activity of Cediranib, a VEGFR-2/3 Tyrosine Kinase Inhibitor, against VEGFR-1 and Members of the Structurally Related PDGFR Family
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3cd5c5600a7c3ff0d61470189a4156
https://doi.org/10.1158/1535-7163.22496464
https://doi.org/10.1158/1535-7163.22496464
Autor:
Simon T. Barry, Stephen R. Wedge, Masabumi Shibuya, Juliane M. Jürgensmeier, Donald J. Ogilvie, Laurent Hennequin, Charles L. Farnsworth, Jeffrey C. Silva, Claire Barnes, Sian Taylor, Graham Sproat, Nicola Broadbent, Philippa Dudley, Jane Kendrew, Anna Wainwright, Sue Ashton, Neil H. James, Zena Wilson, Kirsty Ratcliffe, Sandra R. Brave
Cediranib is a potent inhibitor of the VEGF receptor (VEGFR)-2 and VEGFR-3 tyrosine kinases. This study assessed the activity of cediranib against the VEGFR-1 tyrosine kinase and the platelet-derived growth factor receptor (PDGFR)-associated kinases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c66c6430c693a5c3aeeab117ab20e0f
https://doi.org/10.1158/1535-7163.c.6535279
https://doi.org/10.1158/1535-7163.c.6535279
Autor:
Simon T. Barry, Stephen R. Wedge, Masabumi Shibuya, Juliane M. Jürgensmeier, Donald J. Ogilvie, Laurent Hennequin, Charles L. Farnsworth, Jeffrey C. Silva, Claire Barnes, Sian Taylor, Graham Sproat, Nicola Broadbent, Philippa Dudley, Jane Kendrew, Anna Wainwright, Sue Ashton, Neil H. James, Zena Wilson, Kirsty Ratcliffe, Sandra R. Brave
Supplementary Figure Legend from Assessing the Activity of Cediranib, a VEGFR-2/3 Tyrosine Kinase Inhibitor, against VEGFR-1 and Members of the Structurally Related PDGFR Family
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::908f9c406205b7374b4c5f4dca4484fd
https://doi.org/10.1158/1535-7163.22496461
https://doi.org/10.1158/1535-7163.22496461
Autor:
Chris Womack, Juliane M. Jürgensmeier, Anderson Ryan, Neil Gray, Ruth Swann, Graham Sproat, Susan E. Ashton, Martin Jenkins, Kirsty Ratcliffe, Neil H. James, Dawn Baker, Neil R. Smith
Purpose: Vascular endothelial growth factor (VEGF) signaling is key to tumor angiogenesis and is an important target in the development of anticancer drugs. However, VEGF receptor (VEGFR) expression in human cancers, particularly the relative express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc20ebb5ef55324f5bd484cd9e42d4a
https://doi.org/10.1158/1078-0432.c.6519125.v1
https://doi.org/10.1158/1078-0432.c.6519125.v1
Autor:
Chris Womack, Juliane M. Jürgensmeier, Anderson Ryan, Neil Gray, Ruth Swann, Graham Sproat, Susan E. Ashton, Martin Jenkins, Kirsty Ratcliffe, Neil H. James, Dawn Baker, Neil R. Smith
Supplementary Tables S1-S2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e044ce9f2bed6f91aeaee21540d87e
https://doi.org/10.1158/1078-0432.22442387.v1
https://doi.org/10.1158/1078-0432.22442387.v1
Autor:
Mohamed (Soly) Soliman Ismail, Jonathan Tart, Gareth Davies, Graham Sproat, Tiziana Monterverde, David Hancock, Santosh Adhikari, Christopher Stubbs, Carolyn Blackett, Geoff Holdgate, Jason Kettle, Julian Downward
Publikováno v:
Molecular Cancer Research. 21:B016-B016
RAS proteins contribute to the activation of p110α by directly interacting with its RAS binding domain (RBD), resulting in the promotion of cellular functions such as cell growth, proliferation and survival. Previously, we have shown that blocking t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8794eaa5afbea24522951e1b1060b586
https://doi.org/10.1158/1557-3125.ras23-b016
https://doi.org/10.1158/1557-3125.ras23-b016
Autor:
Juliane M. Jürgensmeier, Zena Wilson, Charles Farnsworth, Jeffrey C. Silva, Masabumi Shibuya, Nicola Broadbent, Taylor Sian Tomiko, Sandra R. Brave, Neil H. James, Philippa Dudley, Donald J. Ogilvie, Simon T. Barry, Graham Sproat, Laurent Francois Andre Hennequin, K Ratcliffe, Jane Kendrew, Susan Ashton, Claire Barnes, Stephen R. Wedge, Anna Wainwright
Publikováno v:
Molecular Cancer Therapeutics. 10:861-873
Cediranib is a potent inhibitor of the VEGF receptor (VEGFR)-2 and VEGFR-3 tyrosine kinases. This study assessed the activity of cediranib against the VEGFR-1 tyrosine kinase and the platelet-derived growth factor receptor (PDGFR)-associated kinases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc51646483d4caf02511b7f9d46a254a
https://doi.org/10.1158/1535-7163.mct-10-0976
https://doi.org/10.1158/1535-7163.mct-10-0976
Autor:
Neil H. James, Anderson J. Ryan, K Ratcliffe, Graham Sproat, Ruth Swann, Susan Ashton, Chris Womack, Martin Jenkins, Neil D. Gray, Neil R. Smith, Dawn Baker, Juliane M. Jürgensmeier
Publikováno v:
Clinical Cancer Research. 16:3548-3561
Purpose: Vascular endothelial growth factor (VEGF) signaling is key to tumor angiogenesis and is an important target in the development of anticancer drugs. However, VEGF receptor (VEGFR) expression in human cancers, particularly the relative express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17afeb7961db2939c4eb37a5150dded9
https://doi.org/10.1158/1078-0432.ccr-09-2797
https://doi.org/10.1158/1078-0432.ccr-09-2797
Publikováno v:
Mechanisms of Development. 91:217-226
We have shown that the 26 bp bx1 element from the regulatory region of Distal-less is capable of imposing control by the homeotic genes Ultrabithorax and abdominal-A on a general epidermal activator in Drosophila . This provides us with an assay to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a9789dcf8f8e8ff90cbf10126115b6
https://doi.org/10.1016/s0925-4773(99)00306-8
https://doi.org/10.1016/s0925-4773(99)00306-8