Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Graham Somers"'
Autor:
Matthew Arno, Jonny Eriksson, Elif Melis Bicer, Ben Forbes, Annelie F. Behndig, Anna Babin Morgan, Dave Hassall, Katarina Edwards, Graham Somers, Paul E Pfeffer, Kenneth A. Dawson, Lea Ann Dailey, Abhinav Kumar, Marco P. Monopoli, Steven Lynham, Ian Mudway, Anders Blomberg
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine. 12:1033-1043
When inhaled nanoparticles deposit in the lungs, they transit through respiratory tract lining fluid (RTLF) acquiring a biomolecular corona reflecting the interaction of the RTLF with the nanomaterial surface. Label-free snapshot proteomics was used
Autor:
Lea Ann Dailey, Kenneth A. Dawson, Jonny Eriksson, Matthew Arno, Graham Somers, Paul E Pfeffer, Abhinav Kumar, Marco P. Monopoli, Elif Melis Bicer, Dave Hassall, Steven Lynham, Annelie F. Behndig, Anders Blomberg, Ian Mudway, Katarina Edwards, Ben Forbes
Publikováno v:
Kumar, A, Bicer, E M, Pfeffer, P, Monopoli, M P, Dawson, K A, Eriksson, J, Edwards, K, Lynham, S, Arno, M, Behndig, A F, Blomberg, A, Somers, G, Hassall, D, Dailey, L A, Forbes, B & Mudway, I 2017, ' Differences in the coronal proteome acquired by particles depositing in the lungs of asthmatic versus healthy humans ', Nanomedicine-Nanotechnology Biology And Medicine, vol. 13, no. 8, pp. 2517-2521 . https://doi.org/10.1016/j.nano.2017.06.008
Most inhaled nanomedicines in development are for the treatment of lung disease, yet little is known about their interaction with the respiratory tract lining fluids (RTLF). Here we combined the use of nano-silica, as a protein concentrator, with lab
Autor:
Brian Edgar Looker, Victoria J. Barrett, Gillian Elizabeth Lunniss, Alison J. Ford, Claire E. Smith, Deborah Needham, Panayiotis A. Procopiou, Graham Somers
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:6026-6032
A series of novel, potent and selective human β(2) adrenoceptor agonists incorporating a urea moiety on the terminal right-hand side phenyl ring of (R)-salmeterol is presented. Urea 9j had long duration of action in vitro on guinea pig trachea, and
Autor:
Claire E. Smith, Rossana Perciaccante, Peter R. Butchers, Alison J. Ford, Gillian Elizabeth Lunniss, Richard Conroy, Séverine Jeulin, Brian Edgar Looker, Graham Somers, Valerie S. Morrison, Amanda Emmons, Panayiotis A. Procopiou, Nicola Bevan, Victoria J. Barrett, Mark Ruston, Peter J. Mutch
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:4192-4201
A series of novel, potent and selective human β(2) adrenoceptor agonists incorporating a hydantoin or a uracil ring on the right-hand side phenyl ring of (R)-salmeterol is presented. Hydantoin 12a had long duration of action in vitro on guinea pig t
Autor:
Ennio Capria, Andrea Fantuzzi, Lok Hang Mak, Gianfranco Gilardi, Stephen P. Collins, Vikash R. Dodhia, Graham Somers, Ejaz Huq, Sheila J. Sadeghi
Publikováno v:
Analytical Chemistry. 82:10222-10227
This paper is the first report of a P450-electrode in a microfluidic format. A 30 μL microfluidic cell was made in poly(methyl methacrylate) containing the inlet, outlet, and reaction chamber with two electrode strips, one of which contains the huma
Publikováno v:
Pharmaceutical Research
Purpose To assess accumulation and lysosomal sequestration of 9 drugs used in respiratory indications (plus imipramine as positive control) in the alveolar macrophage (AM) cell line NR8383. Methods For all drugs, uptake at 5 μM was investigated at 3
Autor:
Panayiotis A, Procopiou, Victoria J, Barrett, Alison J, Ford, Brian E, Looker, Gillian E, Lunniss, Deborah, Needham, Claire E, Smith, Graham, Somers
Publikováno v:
Bioorganicmedicinal chemistry. 19(20)
A series of novel, potent and selective human β(2) adrenoceptor agonists incorporating a urea moiety on the terminal right-hand side phenyl ring of (R)-salmeterol is presented. Urea 9j had long duration of action in vitro on guinea pig trachea, and
Autor:
Lea Ann Dailey, Colin J. Hardy, Per Gerde, Ben Forbes, Graham Somers, Douglas Ferguson, Tim McGovern, Gary R. Pitcairn, Ron K. Wolff, David G. Hassall, Ruth Lock, Rhys M. Jones, Janet Maas, Bahman Asgharian, Lena Gustavsson, Mark Gumbleton
Publikováno v:
Advanced drug delivery reviews. 63(1-2)
Dosimetry, safety and the efficacy of drugs in the lungs are critical factors in the development of inhaled medicines. This article considers the challenges in each of these areas with reference to current industry practices for developing inhaled pr
Autor:
N. Lindsay, Graham Somers, C. Freathy, S. Ho, Martin K. Bayliss, B. M. Lowdon, Gary R. Manchee, Amanda Woodrooffe, A. E. Jones
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 35(10)
The pulmonary and hepatic expression and catalytic activities of phase I and II drug-metabolizing enzymes were compared using human lung and liver tissue, and lung parenchymal cells (LPCs) and cryopreserved hepatocytes. Cytochrome P450 gene expressio
Autor:
Martin, Bayliss, Graham, Somers
Publikováno v:
Methods in molecular medicine. 107